DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and USP6NL

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006717605.1	Gene:	USP6NL / 9712	HGNCID:	16858	Length:	856	Species:	Homo sapiens

Alignment Length:	691	Identity:	156/691 - (22%)
Similarity:	260/691 - (37%)	Gaps:	174/691 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 EVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANV-EGRMEMNDKYK 680
            |..|....:...:|..:|:.|:..|..:.....:..|:|..||.::|..|..: :.:.|..|.|.
Human    92 ERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYS 156

  Fly   681 ILITKETKCETVIQR---DIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIA 742
            .|..:...|...|::   |::|||..|..|::..|..|.:||.|..||:::::|||||||:|.|.
Human   157 KLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQIT 221

  Fly   743 ASLLLHMPEEDAFCVLVALMY--DYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGI 805
            |.||::|.|||||..||.|..  .:.:...:..||..|.......|:::...|.||.:|..:..|
Human   222 ALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEI 286

  Fly   806 ETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYF 870
            .|..|..:||...:..|.|......:.|:::.:|..||..::.|:|.:.:..|.:|..|.::::|
Human   287 YTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFF 351

  Fly   871 RVTLPKKCRSSSQARKVMKQACERKIKKLK------QYEEEFLLKKQHKERLEKEAQIY------ 923
            :.||.|.............|....::|:.|      ..|:|:  .|:...:|..|.|.:
Human   352 QETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEY--PKKPLGQLPPELQSWGVHHLS 414

  Fly   924 --------------------------------ENRFG--------------EERRKMQAEIDALN 942
                                            ::|.|              ||.:|::.|.| ..
Human   415 NGQRSVGRPSPLASGRRESGAPHRRHEHSPHPQSRTGTPERAQPPRRKSVEEESKKLKDEAD-FQ 478

  Fly   943 KQLTSAKERAVEKEKKHTGIIQE-------YKQIIQR--QEQDMNTLSETL-------GKVMH-- 989
            ::|.|..:.: .::..|....|.       .|:.:.:  :..|::....|.       |:..|
Human   479 RKLPSGPQDS-SRQYNHAAANQNSNATSNIRKEFVPKWNKPSDVSATERTAKYTMEGKGRAAHPA 542

  Fly   990 -----------MVSNCQDCQQQIDAGNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRI 1043
                       .|||.:...:.:||       :||| ||.|     |:::...|...|::.:...
Human   543 LAVTVPGPAEVRVSNVRPKMKALDA-------EDGK-RGST-----ASQYDNVPGPELDSGASVE 594

  Fly  1044 RELELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTRGGHR- 1107
            ..||...:|:.             .|.|...........:| .|  ||..|....||......|
Human   595 EALERAYSQSP-------------RHALYPPSPRKHAEPSS-SP--SKVSNKFTFKVQPPSHARY 643

  Fly  1108 -------DNGSGGPMPSFQS---YMGQAP------------------TTLSEASSPSGNQEYKTF 1144
                   ..|...| ||:.:   |.|.:|                  |.|:.:..|.|:.
Human   644 PSQLDGEARGLAHP-PSYSNPPVYHGNSPKHFPTANSSFASPQFSPGTQLNPSRRPHGST----- 702

  Fly  1145 AFASVGGSPK----LPSKFQATKLRNSIDSLRNIVVPLDTG 1181
              .||..||:    .||..       .:.|.|..|:|:|||
Human   703 --LSVSASPEKSYSRPSPL-------VLPSSRIEVLPVDTG 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	67/213 (31%)
		Phage_Gp23	<914..991	CDD:287621	19/157 (12%)
USP6NL	XP_006717605.1	TBC	125..340	CDD:214540	67/214 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810