DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and MSB3

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_014106.1	Gene:	MSB3 / 855423	SGDID:	S000005237	Length:	633	Species:	Saccharomyces cerevisiae

Alignment Length:	449	Identity:	100/449 - (22%)
Similarity:	175/449 - (38%)	Gaps:	102/449 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 EWDPILREW------DSEKR----PKNLAPLVRLGVPEALREKIWQKLANVEGRMEMN-DKYKIL 682
            :|..:|.:.      ||..|    .:.|...||.|:|...|...|...|..:.::..| ..|..|
Yeast   189 KWQLLLEKSGLPVTDDSPSRFPSKSERLKRYVRKGIPAEWRGNAWWHFARGQEKLNKNKGVYSQL 253

  Fly   683 ITKETKCE------------TVIQRDIHRTFPAHKCF------KEIGGSGQDALFKVSKAYAVHD 729
            :.|..:.:            .:|:||::||||.:..|      || |.....:|.:|..|:::::
Yeast   254 LRKMKQIKKQNPNEKQVQDLDIIERDLNRTFPDNIHFQSSLHNKE-GPPIIKSLRRVLVAFSLYN 317

  Fly   730 SEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLP 794
            .::||||.::|:|..|||.:.||.||.:||.:...| |..::....|.:.:....|...:|:.:|
Yeast   318 PKIGYCQSMNFLAGLLLLFLDEERAFWMLVIITSRY-LPGVHNINLEGVNIDQGVLMLCVKEYIP 381

  Fly   795 KLHEHFTACGIETH-------------------------------MYASQWFLTLYTARFPLCFV 828
            ::..:... .|:.|                               :..:.||::.:....|:...
Yeast   382 EVWSYIKP-SIDHHQKNNKTFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETT 445

  Fly   829 FHVLDVFLLDGLPVLFQVAVTLLSICESDLRQL-DFEGILKY-FRVTLPKKCRSSSQARKVMK-- 889
            ..:.|....:....||:|::.:|.:.|.||.:: .....|.| :...|.::..|..|....|:
Yeast   446 LRIWDCLFYEESHFLFKVSLAVLKLSEHDLSKIKPRNNSLNYSWGSNLNQRGGSMGQEDSDMEIF 510

  Fly   890 QACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSAKERAVE 954
            |..:...|.|....|.|            |..|::.||...|.. |.|||...|.:      |.:
Yeast   511 QVIQTFPKTLLNPNEIF------------EKIIFKRRFNLNRLD-QDEIDRCRKFV------AAQ 556

  Fly   955 KEKKHTGIIQEYKQII--QRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDAGNDNAKSD 1011
            :.|..|     |.:::  ...|.|:.....|..|.:|:.|         ||.|:...|:
Yeast   557 RLKFKT-----YGELLGNSTSEADLPINDNTDNKGIHITS---------DAVNEALSSE 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	57/257 (22%)
		Phage_Gp23	<914..991	CDD:287621	19/78 (24%)
MSB3	NP_014106.1	COG5210	15..540	CDD:227535	80/365 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810