Protein Alignment GAPcenA and GYL1

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_013917.1
• Gene: GYL1 / 855230
• SGDID: S000004804
• Length: 720
• Species: Saccharomyces cerevisiae
• Alignment Length: 936
• Identity: 174/936 - (18%)
• Similarity: 321/936 - (34%)
• Gaps: 333/936 - (35%)

  Fly   217 INAPKSETEVYR----IMGELNSGS-----------KSVGLKITVSIPNCSEGLV---VLHDAES 263
            |:.|:.:.:.|.    .|...|:.|           :|:|     :..|..|.|:   :..:::|
Yeast    36 ISVPEGDEKAYSDEKVEMATTNASSNFGSNESAKDGESIG-----AFSNPHEALMQSKLREESQS 95

  Fly   264 NTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDALFQCHVFRCHIPEAVNQVSACFQKAFQT 328
            .||:.:.::|.       .::|.|:                     .:.||:.::::      ..
Yeast    96 KTILPSDDLSQ-------QLETEES---------------------KVEEALKRITS------PP 126

  Fly   329 YPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPRDRGCFKLRAN 393
            .||...|...||..:.:|:...::||                    ||..|  |.||
Yeast   127 LPPRADCIEESASALKSSLPPVLAGN--------------------KNDQA--PLDR-------- 161

  Fly   394 TDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDS 458
                     .|.|                  |.::|..:.:||        ..|.|....::|.:
Yeast   162 ---------PQLP------------------PRQVVNAETLHL--------KAPHGNATPSKSPT 191

  Fly   459 NA--QQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSA 521
            :|  ..|||.|.|:..                             |||::|:
Yeast   192 SAVGNSSSSTPPTLPP-----------------------------RRIEDPL------------- 214

  Fly   522 SEMRIMDHFMS---KRPMTLRFY---------------LHLKRTEESNWKVNSIDPSEEITEQPG 568
             ::....||::   ||.|.  ||               |:||   |.:.|:|:.:..||:
Yeast   215 -DLAAQKHFLASTFKRNML--FYKSEDNSIKCDLDKNILNLK---EDSKKINNNEIPEEV----- 268

  Fly   569 HQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPI 633
               ||..||:                                                :.::..|
Yeast   269 ---SSFWLKV------------------------------------------------IGDYQNI 282

  Fly   634 LREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVIQRDIH 698
            |.. |.|.....|:    .|:|.|.|..:||.::..:.: ..:..|:..:|:      :...|:.
Yeast   283 LIN-DIETLHFQLS----RGIPAAYRLVVWQLVSYAKSK-SFDPIYETYLTE------MAPFDVQ 335

  Fly   699 RTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEED--AFCVLVAL 761
            ......|...|:.......:..|.|||.:.|.|..:...:::| .:::|.:.||:  ||.:||.|
Yeast   336 EFENQLKMMDEVPSEYVKRISNVLKAYLLFDPECEFSTDIAYI-INMILDVCEEEANAFGLLVRL 399

  Fly   762 MYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLC 826
            |..||||.|:......:.:..|:.:||:::..|::|.|....|:.:.|:...:|.||:..:.|..
Yeast   400 MKVYGLRLLFLPSASEIDILCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTE 464

  Fly   827 FVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFR-----------------VTL 874
            ....:.|:..|:|:..:.::..||||.....|.::.|:.:|:..:                 ..|
Yeast   465 IQPRIGDMVFLEGIDSIMRILATLLSNSRDHLLKMGFDDMLELLKSGLLDAYIKQNDGTRGDTLL 529

  Fly   875 PKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEID 939
            ..:|........:||.|...  |.:|:|..|:    :...||:.|.::......|:...:|..:.
Yeast   530 SNECMDKLLQDSMMKVAITP--KTMKKYSSEY----EEIHRLDNEKEVQYKSITEKNLHLQKHVR 588

  Fly   940 ALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDA- 1003
            .|....||.       .::|..|..|   :::.:....:.|:|..|..:.::    |.::::|:
Yeast   589 KLENDYTSL-------NREHVTIANE---LVKNRLNIESVLNENNGYKLQIL----DLKKKLDSE 639

  Fly  1004 ----------GNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQV 1058
                      .||..|..:...:..|..|           |.......||.|||..:.:.|.|.
Yeast   640 KKKQVLGVYVPNDLKKDLEETMKKNTQVM-----------DENLKLQDRISELERLIEEIKTAN- 692

  Fly  1059 EAECKNQDLNHQLSNTLSELQTNRNS 1084
                ||        .||.|...::|:
Yeast   693 ----KN--------GTLFEYSNSKNN 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	20/132 (15%)
		DUF3694	377..523	CDD:463599	23/147 (16%)
		TBC	650..858	CDD:214540	51/209 (24%)
		SMC_prok_B	<876..>1087	CDD:274008	43/220 (20%)
		TPH	<883..>977	CDD:464007	18/93 (19%)
GYL1	NP_013917.1	COG5210	27..569	CDD:227535	141/759 (19%)