DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and sgsm2

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_003200084.2	Gene:	sgsm2 / 799094	ZFINID:	ZDB-GENE-131119-52	Length:	1056	Species:	Danio rerio

Alignment Length:	858	Identity:	142/858 - (16%)
Similarity:	277/858 - (32%)	Gaps:	302/858 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 VATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQEPVRFVIET-- 514
            :...:.|..|:|      :|.:..:..:|.:.|:.::.| ::.|...:..:.:.:.|:::::.
Zfish   100 ITRRTQSTGQES------LRRQGSSTGRAPQPLSAQAIK-HIWVRTALFEKVLDKIVQYIVDNAS 157

  Fly   515 ------------------------PVTIQSASEMRIMDHFM---SKRPMTLRFYLH--------- 543
                                    |..:: .::::..|||.   |...:..|..:|
Zfish   158 KYYEREALMHDSVFGPILAALLVGPCALE-YTKLKTSDHFWTDPSANELVQRHRIHGAHRGQEVS 221

  Fly   544 ---------LKRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNL-------SRIVRS-SS 591
                     .||....:...:....|.....:..||.|...|..|.||:       ..::|. .|
Zfish   222 PGRRPALGIRKRQSSGSMSEDKFAASAREYVESLHQNSRVHLLYGKNNVLVQPKKDMEVLRGYLS 286

  Fly   592 IASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWD------------------P------ 632
            :....:.....::.:   .|::||   ..||..:....||                  |
Zfish   287 LHQTAETLTLKWTPN---QLINGT---LGDCDLEKSIYWDYALTVPLRQIVCIHCHQRPDCGGTL 345

  Fly   633 ILREWDSEKRPKNLAP-----LVRLGVPEA-------LREKIWQKLANVEGRMEMNDKYKILITK 685
            :|...|..:||....|     |..|...|.       |...:|.:    .|:.::..|    :.|
Zfish   346 VLVSQDGIQRPPLHFPPGGHLLAFLSCLETGLLPRGQLEPPLWSQ----RGKGKVFPK----LRK 402

  Fly   686 ETKCETVIQRDIHRTFPAHKCFKEIGGSGQDAL-----FKVSKAYAVHDS-EVGYCQGLSFIAAS 744
            ......::.:|               |.|:|.:     |::......||| .:.|.......|.|
Zfish   403 RNSTARLVDQD---------------GDGEDQIAADYVFRIVYPGHRHDSITINYHHSTGSRAPS 452

  Fly   745 LLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKD-----------------Q 792
            |.....|||....:::::....|.|                ..::||                 |
Zfish   453 LDDDEEEEDRLHAMISMICSRNLTD----------------PNVMKDHGDLMEMQGFGGSPLSWQ 501

  Fly   793 LPKLHEHFTAC--------GIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVT 849
            ..:...|.::|        .....:.||             |...|       |.:|
Zfish   502 QGECTSHMSSCLSCSTGGSNASVELPAS-------------CTCMH-------DRIP-------- 538

  Fly   850 LLSICESDLRQL---DFEGILKYFR-----------------VTLPKKCRSSSQARKVMKQACER 894
            |..:|::..||:   .|.|.|.|.|                 |...|.|.:|.   .:.|....:
Zfish   539 LKMLCQNMKRQIVSRAFYGWLAYCRHLSTVRTHLSALVNHNIVPPDKPCEASG---GLSKDVWSK 600

  Fly   895 KIKKLKQYEEEFLLKKQHKERLEKEAQ-------IYENRFGEERRKMQAEIDALNKQLTSAKERA 952
            ..|..|.|:|..||:..:...:|.|.:       :...:||.:::.| |:||   :::|:
Zfish   601 YQKDCKNYKELELLRLVYYGGVEHEIRKEVWPFLLGHYKFGMDKKNM-AQID---EKITA----- 656

  Fly   953 VEKEKKHTGIIQEYKQ---IIQRQEQDMNTL--------SETLGKVMHMVSNCQDCQQQI----- 1001
                 ::..:::|:|.   |::::|::|.:.        |.....|:.::........::
Zfish   657 -----RYQQVMREWKACEVIVKQREKEMQSAIFAKLSSGSSIDSHVLRLIHRDSTISNEVFMSVD 716

  Fly  1002 --DAGNDNAKSDDGK---NRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAE 1061
              |||..:...:|..   ....|.||...:|.||...|..::.....|
Zfish   717 EPDAGGQDTSCEDSTPTLTTVVTPAMLAPDERPLVEFDSPDSGLPSSR----------------- 764

  Fly  1062 CKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTRGGHRDNGSGGPMPSFQ--SYMGQ 1124
                  |:.:::..|::.::.:..|        |::|..|..||..:.|..|.:...:  |.:.:
Zfish   765 ------NYSVASGHSQIMSSIDDGQ--------SMEEDTTPTGGLEEQGGRGSLSEDKLCSQLDK 815

  Fly  1125 APTT-LSEASSPS 1136
            ..|| .||.::||
Zfish   816 LTTTSSSEGTAPS 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	10/96 (10%)
		TBC	650..858	CDD:214540	37/245 (15%)
		Phage_Gp23	<914..991	CDD:287621	16/94 (17%)
sgsm2	XP_003200084.2	RUN	43..189	CDD:308412	10/96 (10%)
		PH_RUTBC	262..432	CDD:275431	32/198 (16%)
		TBC	<844..1013	CDD:214540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900