DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and GRTP1

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001273661.1	Gene:	GRTP1 / 79774	HGNCID:	20310	Length:	344	Species:	Homo sapiens

Alignment Length:	281	Identity:	81/281 - (28%)
Similarity:	132/281 - (46%)	Gaps:	33/281 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 EWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILI---TKETKCE 690
            :|..:| :.....|.:.:...||.|||...|.::|..|:..:.:|:.|..|...:   .:..:.|
Human    45 KWSRLL-QGGGVPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLE 108

  Fly   691 TVIQRDIHRTFPAHKCF-KEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASL-LLHMPEED 753
            ..|:.|::||||.:..| |......|..|:.|..||..|:..||||||::|||..| |:...||:
Human   109 DAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEE 173

  Fly   754 AFCVLVALMYDYG--LRDLYKAGFEVLYLRLYQ--LERLIKDQLPKLHEHFTACGIETHMYASQW 814
            :|.:|.||:   |  |.|.|...  :|.|:..|  |..|::.:||.:.......|:...:..|:|
Human   174 SFWLLDALV---GRILPDYYSPA--MLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRW 233

  Fly   815 FLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCR 879
            |:.|:....|:..|..:.|....:|..::|:||:||:    ...::|..|.      .::|..|.
Human   234 FICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLI----KQHQELILEA------TSVPDICD 288

  Fly   880 SSSQARK---VMK-----QAC 892
            ...|..|   ||:     |.|
Human   289 KFKQITKGSFVMECHTFMQVC 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	68/216 (31%)
		Phage_Gp23	<914..991	CDD:287621
GRTP1	NP_001273661.1	TBC	65..278	CDD:214540	69/221 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810