DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and EVI5

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_016857758.1	Gene:	EVI5 / 7813	HGNCID:	3501	Length:	930	Species:	Homo sapiens

Alignment Length:	752	Identity:	195/752 - (25%)
Similarity:	321/752 - (42%)	Gaps:	205/752 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   447 PGGTGVATESDSNAQQSS-SW-----PYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQ 505
            |.|..|||:..:....|: ||     .:|:  ...|.:.|....:|.::.::.|
Human    13 PSGKQVATDKVAEKLSSTLSWVKNTVSHTV--SQMASQVASPSTSLHTTSSSTT----------- 64

  Fly   506 EPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQ 570
                  :.||....|:...      :|...:.|     |.:.||.|..:.:  .|:.:....|.:
Human    65 ------LSTPALSPSSPSQ------LSPDDLEL-----LAKLEEQNRLLET--DSKSLRSVNGSR 110

  Fly   571 QSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILR 635
            ::|     |.:.:|....||:::.:|                           :|:...|..|:.
Human   111 RNS-----GSSLVSSSSASSNLSHLE---------------------------EDSWILWGRIVN 143

  Fly   636 EWDS--EKRPKNLAP---------------------------LVRLGVPEALREKIWQKLANVEG 671
            ||:.  :|:.|.:.|                           ||..|:|...|..:||.|.:.:.
Human   144 EWEDVRKKKEKQVKPFECWVLYHHSQLCRFQVHYLKRSHTEELVHKGIPHHFRAIVWQLLCSAQS 208

  Fly   672 RMEMNDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQ 736
             |.:.|:|..|:...:.||.:|:|||.||:|.|..|||....||:.||.|.|||::.|.||||||
Human   209 -MPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQ 272

  Fly   737 GLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFT 801
            |.:||...||:.||||:||||.|.||.||.||:|:|.....|.|.:||.|.:|::.||:|..||.
Human   273 GSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 337

  Fly   802 ACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGI 866
            :....|.||||.||||::...|||.....:.|:|:.:||.::|:|.:.||.:.:::|.|||.||:
Human   338 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGM 402

  Fly   867 LKYFRVTLPKKCRSSSQARKVMKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGE 929
            |::|:..:|.  :......|:::.|.:.|.  ||:|:.|:|:...|..    |.|.|:...|...
Human   403 LQHFQKVIPH--QFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTK----EMEEQVEIKRLRT 461

  Fly   930 ERRKMQAEIDALNKQLTSAKERAVE------KEKKHTGIIQEYKQIIQRQEQDMNTLSE----TL 984
            |.|.::..|:.|.|:..|..:|.::      :|.:...:|:.....|::|..:.:...|    |:
Human   462 ENRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASAKLEQAENTI 526

  Fly   985 GKVMHMVSNCQDCQQQIDAGNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELE 1049
            .|:.|        |||....:.|...|                              .:.:||.|
Human   527 RKLQH--------QQQWHKCSSNYNED------------------------------FVLQLEKE 553

  Fly  1050 LAQAKLAQVEAECKNQDL----------NHQL--SNTLSELQTN--------------------- 1081
            |.||:|::.|::|..:::          |:.|  .|.::.||..
Human   554 LVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQ 618

  Fly  1082 ----RNSWQPWLSKT------------FNSLQEKVTT 1102
                ...||..|::|            .|.||:::.|
Human   619 VKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMT 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	16/81 (20%)
		TBC	650..858	CDD:214540	92/207 (44%)
		Phage_Gp23	<914..991	CDD:287621	19/86 (22%)
EVI5	XP_016857758.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920