Protein Alignment GAPcenA and tbc1d2b

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: XP_012822167.2
• Gene: tbc1d2b / 734055
• XenbaseID: XB-GENE-5932742
• Length: 944
• Species: Xenopus tropicalis
• Alignment Length: 1085
• Identity: 221/1085 - (20%)
• Similarity: 379/1085 - (34%)
• Gaps: 331/1085 - (30%)

  Fly    32 MEQVKQVVNQEGTQPEVGGKPPTSLSALALSSPEAGGDRSP-----------------------T 73
            |..|:...:.:||.||   :|.||     ::..||..::||                       .
 Frog     1 MPGVEDPCDSQGTPPE---EPSTS-----VAPGEAAKEQSPRLCGYLAKLSGKGPLRSFKNRWFV 57

  Fly    74 LD--------MAHNRNLSDM-QHEMTDA--LKDLELERG---VAASGEKSAQRLPSH-------- 116
            ||        ..|:::...: |.::.||  ..|||.|.|   :.::|..|..|.||.
 Frog    58 LDPRKCQFYYFKHHQDAQPLGQIDIGDASFSYDLEAEEGQFEIHSAGRVSILRAPSRHAMTYWLQ 122

  Fly   117 --QQKSLTLPLTGSGGGSVDPEMRFPCTLF-TPKSEETLDDASSSNRVG----HSVFYDCI---- 170
              |||....                 |..| ..|.|..::.||:...:|    .|..|..|
 Frog   123 ELQQKRWEY-----------------CNSFGALKRESVINPASTKVPIGLVARESPDYMGIPNIN 170

  Fly   171 DASPACVEEKQDAMKPEKGDTTDEEVSEIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNS 235
            ||..|..:...:......||.|..|.:..:.           .|..:...:...::...|..|..
 Frog   171 DAERARNQFAVETCPSVLGDQTSAEQASNNP-----------AAVQVLLRQWSNDIRSSMQHLRP 224

  Fly   236 GSKSVGLKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYY---RGPVDTVENGC--FAFTW 295
            |..|          :|.:.....::..........|:...:|:.   :.|.:.::...  .:|.:
 Frog   225 GKSS----------DCRKSTFYTNEEWELLNPTPKELEESLLHVEKRKPPTEGIKGSTAGMSFPF 279

  Fly   296 LHGDALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAG 360
            ..|           .||          |:|.:.....|..:.|....:|:|:       |::.:.
 Frog   280 DFG-----------RIP----------QRARRPLREIMGVNKNRTECLADSL-------PVSDSR 316

  Fly   361 YEFIVSLEIR------ERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCF 419
            .|..|.|:::      ||:.|:..               :.||:...::|:    |:....::.|
 Frog   317 MESDVLLKLQSQEEELERLKKDLL---------------SQKELVRLLQQS----LRSSQYDKYF 362

  Fly   420 GVLVAPG------KLVVQKDM------HLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRA 472
            ......|      .|:.|||.      ||::..::            |.|...|:..
 Frog   363 ASPFCDGLSKEHLHLLQQKDTQIQELNHLLERQTL------------EKDHLHQEVE-------- 407

  Fly   473 EWKAQEKAF-EQLNLESSKTNLTVAVDIVMRRIQEPVRF---------VIETPVTIQSASEMRIM 527
            |.|...|.. :|||:  ....:....:::||..::..::         ..|.||..|.....|:.
 Frog   408 ELKCSVKELKDQLNM--MMETIQAKDEVIMRLSRQLSKYEQHTPSSTVAAEIPVAPQLEELNRLQ 470

  Fly   528 DH---------FMSK----------------RPMTLRF-------------YLHLKRTEESNWKV 554
            |.         |::|                |.|..|:             ||.|  .:|....|
 Frog   471 DSLQGYKAQNTFLNKEILELSALRRNAERREREMEARYSNLEAKMCQIESKYLVL--LQEMKTPV 533

  Fly   555 NSIDPSE---------------EITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYS 604
            .|.|...               |..|||.|    :.:|  .:.:|:......:...|||
 Frog   534 CSDDQGTAREFVNQLLEDALKVENAEQPEH----TFVK--PHTVSKYDIHGFLIVPEDD------ 586

  Fly   605 SDGDEPLLS-------GTGEVSKDCSQDTLDEWD-----PILREWDSEKRPKNLAPLVRLGVPEA 657
             :.:|.|::       .|..::::.....:.:||     .:.||....   ..|..|||.|:|..
 Frog   587 -EEEEKLVAKVRALDLKTLSLTENQEISNVVKWDNYFASTVNREMACS---PELKALVRNGIPHE 647

  Fly   658 LREKIWQKLANVEGRMEMNDK-----YKIL----ITKETKCETVIQRDIHRTFPAHKCFKEIGGS 713
            .|.::|:...|:..: ::.|:     ::.|    :.|:......|:.|:.||.|.:|.:......
 Frog   648 HRSRMWKWFTNLHIK-KLKDEAAPGYFQSLLQNALEKQNPASKQIELDLMRTLPNNKHYTSPTSE 711

  Fly   714 GQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYK---AGF 775
            |...|..|..||:..:.::|||||::.:||..||::.:||||..||.::..:..||.|.   .|.
 Frog   712 GIQKLRNVLLAYSWRNPDIGYCQGINRLAAIALLYLDQEDAFWCLVTIVEAFMPRDYYTKTLLGS 776

  Fly   776 EVLYLRLYQLERLIKD----QLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFL 836
            :|       .:|:.||    :||:|..||....::..:....|||.::........:|.:.|..|
 Frog   777 QV-------DQRVFKDLMNEKLPRLCAHFEQYKVDYTLITFNWFLVVFVDSVVSDILFRIWDSLL 834

  Fly   837 LDGLPVLFQVAVTLLSICESDLRQL-DFEGILKYFRVTLPKKCRSSSQARKV-------MKQACE 893
            .:|..|:|:.|:.|....|.::.:| |...|.||.|..    .|:...|||:       |.....
 Frog   835 YEGSKVIFRFALGLFKYKEEEILKLQDSMSIFKYLRYF----SRTILDARKLCNIAFVDMNPFPL 895

  Fly   894 RKIKKLKQYEEEFLLKKQHKERLEKEA----QIYENRFGEERRKM 934
            |:|:..:.|.    |:|...|..|.||    .|.|.....|||.:
 Frog   896 RQIRNRRTYH----LEKVRLELSELEAIRADFIRERETNPERRDL 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	15/132 (11%)
		DUF3694	429..523	CDD:289256	20/109 (18%)
		TBC	650..858	CDD:214540	61/223 (27%)
		Phage_Gp23	<914..991	CDD:287621	9/25 (36%)
tbc1d2b	XP_012822167.2	PH_TBC1D2A	34..134	CDD:269966	20/116 (17%)
		BAR	313..>425	CDD:416402	27/152 (18%)
		Smc	<324..532	CDD:224117	41/250 (16%)
		TBC	640..857	CDD:214540	61/224 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910