Protein Alignment GAPcenA and tbc1d2b

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: XP_012822167.2
• Gene: tbc1d2b / 734055
• XenbaseID: XB-GENE-5932742
• Length: 944
• Species: Xenopus tropicalis
• Alignment Length: 1084
• Identity: 220/1084 - (20%)
• Similarity: 381/1084 - (35%)
• Gaps: 329/1084 - (30%)

  Fly    32 MEQVKQVVNQEGTQPEVGGKPPTSLSALALSSPEAGGDRSP-----------------------T 73
            |..|:...:.:||.||   :|.||     ::..||..::||                       .
 Frog     1 MPGVEDPCDSQGTPPE---EPSTS-----VAPGEAAKEQSPRLCGYLAKLSGKGPLRSFKNRWFV 57

  Fly    74 LD--------MAHNRNLSDM-QHEMTDA--LKDLELERG---VAASGEKSAQRLPSH-------- 116
            ||        ..|:::...: |.::.||  ..|||.|.|   :.::|..|..|.||.
 Frog    58 LDPRKCQFYYFKHHQDAQPLGQIDIGDASFSYDLEAEEGQFEIHSAGRVSILRAPSRHAMTYWLQ 122

  Fly   117 --QQKSLTLPLTGSGGGSVDPEMRFPCTLF-TPKSEETLDDASSSNRVG----HSVFYDCI---- 170
              |||....                 |..| ..|.|..::.||:...:|    .|..|..|
 Frog   123 ELQQKRWEY-----------------CNSFGALKRESVINPASTKVPIGLVARESPDYMGIPNIN 170

  Fly   171 DASPACVEEKQDAMKPEKGDTTDEEVSEIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNS 235
            ||..|..:...:......||.|..|.:..:.           .|..:...:...::...|..|..
 Frog   171 DAERARNQFAVETCPSVLGDQTSAEQASNNP-----------AAVQVLLRQWSNDIRSSMQHLRP 224

  Fly   236 GSKSVGLKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYY---RGPVDTVENGC--FAFTW 295
            |..|          :|.:.....::..........|:...:|:.   :.|.:.::...  .:|.:
 Frog   225 GKSS----------DCRKSTFYTNEEWELLNPTPKELEESLLHVEKRKPPTEGIKGSTAGMSFPF 279

  Fly   296 LHGDALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAG 360
            ..|           .||          |:|.:.....|..:.|....:|:|:       |::.:.
 Frog   280 DFG-----------RIP----------QRARRPLREIMGVNKNRTECLADSL-------PVSDSR 316

  Fly   361 YEFIVSLEIR------ERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCF 419
            .|..|.|:::      ||:.|:..               :.||:...::|:    |:....::.|
 Frog   317 MESDVLLKLQSQEEELERLKKDLL---------------SQKELVRLLQQS----LRSSQYDKYF 362

  Fly   420 GVLVAPG------KLVVQKDM------HLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRA 472
            ......|      .|:.|||.      ||::..::            |.|...|:......:::
 Frog   363 ASPFCDGLSKEHLHLLQQKDTQIQELNHLLERQTL------------EKDHLHQEVEELKCSVK- 414

  Fly   473 EWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQEPVRF---------VIETPVTIQSASEMRIMD 528
            |.|      :|||:  ....:....:::||..::..::         ..|.||..|.....|:.|
 Frog   415 ELK------DQLNM--MMETIQAKDEVIMRLSRQLSKYEQHTPSSTVAAEIPVAPQLEELNRLQD 471

  Fly   529 H---------FMSK----------------RPMTLRF-------------YLHLKRTEESNWKVN 555
            .         |::|                |.|..|:             ||.|  .:|....|.
 Frog   472 SLQGYKAQNTFLNKEILELSALRRNAERREREMEARYSNLEAKMCQIESKYLVL--LQEMKTPVC 534

  Fly   556 SIDPSE---------------EITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSS 605
            |.|...               |..|||.|    :.:|  .:.:|:......:...|||
 Frog   535 SDDQGTAREFVNQLLEDALKVENAEQPEH----TFVK--PHTVSKYDIHGFLIVPEDD------- 586

  Fly   606 DGDEPLLS-------GTGEVSKDCSQDTLDEWD-----PILREWDSEKRPKNLAPLVRLGVPEAL 658
            :.:|.|::       .|..::::.....:.:||     .:.||....   ..|..|||.|:|...
 Frog   587 EEEEKLVAKVRALDLKTLSLTENQEISNVVKWDNYFASTVNREMACS---PELKALVRNGIPHEH 648

  Fly   659 REKIWQKLANVEGRMEMNDK-----YKIL----ITKETKCETVIQRDIHRTFPAHKCFKEIGGSG 714
            |.::|:...|:..: ::.|:     ::.|    :.|:......|:.|:.||.|.:|.:......|
 Frog   649 RSRMWKWFTNLHIK-KLKDEAAPGYFQSLLQNALEKQNPASKQIELDLMRTLPNNKHYTSPTSEG 712

  Fly   715 QDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYK---AGFE 776
            ...|..|..||:..:.::|||||::.:||..||::.:||||..||.::..:..||.|.   .|.:
 Frog   713 IQKLRNVLLAYSWRNPDIGYCQGINRLAAIALLYLDQEDAFWCLVTIVEAFMPRDYYTKTLLGSQ 777

  Fly   777 VLYLRLYQLERLIKD----QLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLL 837
            |       .:|:.||    :||:|..||....::..:....|||.::........:|.:.|..|.
 Frog   778 V-------DQRVFKDLMNEKLPRLCAHFEQYKVDYTLITFNWFLVVFVDSVVSDILFRIWDSLLY 835

  Fly   838 DGLPVLFQVAVTLLSICESDLRQL-DFEGILKYFRVTLPKKCRSSSQARKV-------MKQACER 894
            :|..|:|:.|:.|....|.::.:| |...|.||.|..    .|:...|||:       |.....|
 Frog   836 EGSKVIFRFALGLFKYKEEEILKLQDSMSIFKYLRYF----SRTILDARKLCNIAFVDMNPFPLR 896

  Fly   895 KIKKLKQYEEEFLLKKQHKERLEKEA----QIYENRFGEERRKM 934
            :|:..:.|.    |:|...|..|.||    .|.|.....|||.:
 Frog   897 QIRNRRTYH----LEKVRLELSELEAIRADFIRERETNPERRDL 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	15/132 (11%)
		DUF3694	377..523	CDD:463599	26/166 (16%)
		TBC	650..858	CDD:214540	61/223 (27%)
		SMC_prok_B	<876..>1087	CDD:274008	19/70 (27%)
		TPH	<883..>977	CDD:464007	18/63 (29%)
tbc1d2b	XP_012822167.2	PH_TBC1D2A	34..134	CDD:269966	20/116 (17%)
		Smc	322..>560	CDD:440809	45/279 (16%)
		TBC	640..857	CDD:214540	61/224 (27%)