Protein Alignment GAPcenA and Tbc1d8

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: XP_006244913.1
• Gene: Tbc1d8 / 680133
• RGDID: 1595491
• Length: 1150
• Species: Rattus norvegicus
• Alignment Length: 957
• Identity: 197/957 - (20%)
• Similarity: 335/957 - (35%)
• Gaps: 299/957 - (31%)

  Fly   469 TIRAEWKAQEKAFEQ-LNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMS 532
            |||...:.:|:.|.. |||:.....:....|:.:||:.:  ..|.:....:|..|::...|....
  Rat   234 TIRITTQNKERDFSTFLNLDEVFKIMEQLADVTLRRLLD--NEVFDLDPDLQEPSQITKRDLEAR 296

  Fly   533 KRPMTLRFYLHLKRTEE-------SNW------------------------------------KV 554
            .:....|.:..|.|.|:       |.|                                    :|
  Rat   297 AQNEFFRAFFRLPRKEKLHAVVDCSLWTPFSRCHTAGRIFSSDSYICFASREDGCCHVVLPLREV 361

  Fly   555 NSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASI--------------------EDD- 598
            .||:..|:.:..|.....|...||....:....|.:.:..:                    :||
  Rat   362 VSIEKMEDTSLLPNPIIVSIRSKMAFQFIELKDRENLVEGLLLRLKQVHANHPVHYETSPSDDDM 426

  Fly   599 -CPSDYSSD------GDEPLLSGTGEVSKDCSQDTLDEWDPIL----------------RE---- 636
             .|..||:.      ||..::|......::..:..|...:|:.                ||
  Rat   427 ASPVFYSTSICTDKFGDLEMVSSQSSEEREKEKSPLPHPEPLTAVFQQSGSQSPDSRLSREQIKI 491

  Fly   637 --WDSE----------KRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYK--------- 680
              |:..          .|.:.:..||.:|:||:||.::|...::....:..:..|.
  Rat   492 SLWNDHFAEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEQSLG 556

  Fly   681 --ILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAA 743
              .|:|:|      |:||:||:.|.|..|:  ..:|..||.:|..|||..:.::||||.::.:.:
  Rat   557 RCCLVTEE------IERDLHRSLPEHPAFQ--NETGIAALRRVLTAYAHRNPKIGYCQSMNILTS 613

  Fly   744 SLLLHMPEEDAFCVLVA----LMYDYGLRDLYKAGFEVLYLRLYQ--LERLIKDQLPKLHEHFTA 802
            .|||:..||:||.:|||    ::.||       ....|:..::.|  .|.|||:.||:|.||.:.
  Rat   614 VLLLYAKEEEAFWLLVAVCERMLPDY-------FNHRVIGAQVDQSVFEELIKEHLPELAEHMSD 671

  Fly   803 CGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLL-----SICES------ 856
            ......:..| |||||:.:..||....:|:|.|..||:..:||:.:.:|     .:|.|
  Rat   672 LSALASISLS-WFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEELCSSKDDGQA 735

  Fly   857 ---------DLRQLDFEG---------------------ILKYFRVTLPKKCRSSSQARKVMKQA 891
                     .::..|..|                     |....|.:..|  ..:....::....
  Rat   736 LMILSRFLDHIKNEDSPGPPIGSHHAFFSDDQEPCPVTDIADLIRDSYEK--FGNQSVEQIEHLR 798

  Fly   892 CERKIKKLKQYEEEFLLKKQHKERL---------EKEAQIYE--------NRFGEERRKM----- 934
            |:.:|:.|:.:|:   ..||:..|:         |...::|:        |.:.|..|.:
  Rat   799 CKHRIRVLQGHED---TTKQNVLRVVIPEVSILPEDLEELYDLFKRAHMMNCYWEHHRPIALRHD 860

  Fly   935 -------QAEIDALN----KQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVM 988
                   |..|||..    .||.|......     ||.|:.|  :|.:..:.:|:.|.|....|
  Rat   861 PSRPYAEQYRIDACQFAHLFQLVSPWTCGA-----HTEILAE--RIFRLLDDNMDQLIEFKAFV- 917

  Fly   989 HMVSNCQDCQQQIDAGNDNAKSDDGK--------------NRGQTDAMRN---ANEHPL------ 1030
                :|      :|...:...|:..|              :|.....::|   :...||
  Rat   918 ----SC------LDVMYNGEMSEKIKLLYRLHIPPALTENDRDSQSPLKNPLLSTSRPLVLGRPN 972

  Fly  1031 -GPLDPLNAASQRIREL-----ELELAQAKLAQVE--AECKNQDLNHQLSNTLSELQTNRNSWQP 1087
             ..:|......|.|::|     ::|....|::|.|  ..||.      |.:...|.....:.:|.
  Rat   973 GDTIDYQKQLKQMIKDLAKEKDKMEKELPKMSQREFIQFCKT------LYSMFHEDPEENDLYQA 1031

  Fly  1088 WLSKTFNSLQEKVTTRGGHRDNGSGGPMPSFQSYMGQAPTTLSEASSPSGNQEYKTFAFASVGGS 1152
            ..:.|...||   ....|.|.:.||......:.....||   .|..|          .||..|
  Rat  1032 IATVTTLLLQ---IGEVGQRGSSSGSCSQECEEPQASAP---PEQDS----------VFAEAG-- 1078

  Fly  1153 PKLPSKFQATKLRNSIDSLRNIVVPLDTGKTLAE------NLKQQLQ 1193
             |.|..|..|:...:: ||.:|:..|.|.::|..      |:|.:|:
  Rat  1079 -KSPQAFPETEGDWTV-SLEHILASLLTEQSLVNFFEKPLNIKSKLE 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	377..523	CDD:463599	13/54 (24%)
		TBC	650..858	CDD:214540	71/244 (29%)
		SMC_prok_B	<876..>1087	CDD:274008	49/274 (18%)
		TPH	<883..>977	CDD:464007	24/126 (19%)
Tbc1d8	XP_006244913.1	PH-GRAM1_TBC1D8	171..269	CDD:270156	9/34 (26%)
		PH-GRAM2_TBC1D8	311..406	CDD:270160	12/94 (13%)
		TBC	520..726	CDD:214540	68/221 (31%)