Protein Alignment GAPcenA and Tbc1d2b

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_919315.2
• Gene: Tbc1d2b / 67016
• MGIID: 1914266
• Length: 965
• Species: Mus musculus
• Alignment Length: 753
• Identity: 150/753 - (19%)
• Similarity: 275/753 - (36%)
• Gaps: 236/753 - (31%)

  Fly   346 SVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQT----- 405
            :.:|..||.|...     :..::::.:..:.....:.:|       .::.||:...::||
Mouse   326 ATSSGSSGGPTKP-----VPEMQLQIQSQQEELEQLKKD-------LSSQKELIRLLQQTVRSSQ 378

  Fly   406 --------------PSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATES 456
                          |.:.|:.||                |||..::.:  .|.::..|    .|.
Mouse   379 YDKYFTNPQISQGVPGDTLELLH----------------QKDEQILGL--SGQLERFG----LEK 421

  Fly   457 DSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQEPVRFVIE-------- 513
            :|..|                    |...|:|....|...:.::|..||.....:|:
Mouse   422 ESLQQ--------------------EVRTLKSKVGELNERLGMLMETIQAKDEVIIKLSACEGSV 466

  Fly   514 --------TPVTIQSASEMRIMDH-------------FMSKRPMTLRFYLHLKRTEESN-----W 552
                    :|:.|.::.:...:|.             |::|..:.|.   .|:|..|..     .
Mouse   467 SSPTLGPSSPLAIPASKDQLELDRLKDSLQGYKSQNKFLNKEILELS---ALRRNAERRERDLMA 528

  Fly   553 KVNSIDP---------------------SEEITEQPGHQQSSSLLKMGMNNLSR------IVRSS 590
            |.:|::.                     |||  :.|.....:.||:..:...|:      .|:..
Mouse   529 KYSSLEAKLCQVESKYLILLQEMKTPVCSEE--QGPARDVIAQLLEDALQVESQEQPEQAFVKPH 591

  Fly   591 SIASIE----DDCPSDYSSDGDEPL-------------LSGTGEVSKDCSQDTLDEWD-----PI 633
            .::..:    ...|.|   |.:|.|             |:...|||      |..:|:     .:
Mouse   592 LVSEFDIYGFRTVPDD---DEEEKLVAKVRALDLKTLYLTDNQEVS------TGVKWENYFASTM 647

  Fly   634 LREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGR-----MEMNDKYKIL----ITKETKC 689
            .||.......||   |:|.|:|...|.|:|:...:...|     || .|.::.|    :.|:...
Mouse   648 NREMACSPELKN---LIRAGIPHEHRSKVWKWCVDRHTRKFKDSME-PDYFQTLLQKALEKQNPA 708

  Fly   690 ETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDA 754
            ...|:.|:.||.|.:|.:......|...|..|..|::..:.::||||||:.:.|..||::.:|||
Mouse   709 SKQIELDLLRTLPNNKHYSSPTSEGIQKLRSVLLAFSWRNPDIGYCQGLNRLVAVALLYLDQEDA 773

  Fly   755 FCVLVALMYDYGLRDLYK---AGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFL 816
            |..||.::..:..||.|.   .|.:| ..|:::  .|:.::||:||.||....::..:....|||
Mouse   774 FWCLVTIVEVFMPRDYYTKTLLGSQV-DQRVFR--DLLSEKLPRLHTHFEQYKVDYTLITFNWFL 835

  Fly   817 TLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQL-DFEGILKYFRVTLPKKCRS 880
            .::........:|.:.|.||.:|..|:|:.|:.|....|.::.:| |...|.||.|..    .|:
Mouse   836 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYF----TRT 896

  Fly   881 SSQARKVMKQACE-------RKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEI 938
            ...|||::..:..       |:|:..:.|..|       |.|||                 ..|:
Mouse   897 ILDARKLISISFGDLNPFPLRQIRNRRAYHLE-------KVRLE-----------------LTEL 937

  Fly   939 DALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQD 976
            :|:.:.....::.:.:|           .:::..:|:|
Mouse   938 EAIREDFLRERDTSPDK-----------GELVSDEEED 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	377..523	CDD:463599	27/180 (15%)
		TBC	650..858	CDD:214540	63/219 (29%)
		SMC_prok_B	<876..>1087	CDD:274008	17/108 (16%)
		TPH	<883..>977	CDD:464007	16/101 (16%)
Tbc1d2b	NP_919315.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		PH_TBC1D2A	36..144	CDD:269966
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..288
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..340		4/18 (22%)
		CwlO1	345..>586	CDD:443091	43/294 (15%)
		RabGAP-TBC	709..878	CDD:459855	51/171 (30%)