DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Tbc1d15

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006514020.1	Gene:	Tbc1d15 / 66687	MGIID:	1913937	Length:	688	Species:	Mus musculus

Alignment Length:	543	Identity:	106/543 - (19%)
Similarity:	201/543 - (37%)	Gaps:	156/543 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 ESDSNAQQSSSWPYTI---------------RAEWKAQEKAFEQ--LNLESSKTNLTVAVDIVMR 502
            :|...:::...|.|.:               :.:.|...::.|:  :..||.:.:.|:.|:...:
Mouse   136 KSVKQSKEGMGWSYLVFCLKDDVMLPALHFHQGDSKLLIESLEKYVVLCESPQDSRTLLVNCQNK 200

  Fly   503 RIQEPVRFVIETPV--TIQSASEMRIMD---------HF--MSKRPMTLRFYLHLKRTEESNWKV 554
            .:.:....:::.|.  .||:.    ::|         |:  :.|.|.|.......|.|   |:..
Mouse   201 SLSQSFENLLDEPAYGLIQAG----LLDRRKLLWAIHHWRKIKKDPYTATMVGFSKVT---NYIF 258

  Fly   555 NSIDPSEEITEQ--------------PG---HQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSD 602
            :|:..|:..|.|              ||   :||.    :.|...::||
Mouse   259 DSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQE----EPGFEVITRI---------------- 303

  Fly   603 YSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKR----PKNLAPLVRLGVPEALREKIW 663
              ..|:.|::.....||       |:||:..|   |.|.|    ......:.|.|:..:||::.|
Mouse   304 --DLGERPVVQRREPVS-------LEEWNKSL---DPEGRLVAVESMKQKIFRGGLSHSLRKQAW 356

  Fly   664 QKL-------ANVEGRMEM----NDKY-------KILITKETK-------CETVIQRDIHRTFPA 703
            :.|       :..|.|.::    .|:|       |.:...:.|       ..::|::|::||...
Mouse   357 KFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSVSEAQEKRNSRLRDYRSLIEKDVNRTDRT 421

  Fly   704 HKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEE-DAFCVLVALMYDYGL 767
            :|.::.....|...|..:...|.::|.::||.||:|.:.:.||..|..| |||....:.|
Mouse   422 NKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYM----- 481

  Fly   768 RDLYKAGFEV----LYLRLYQLERLIKDQLPKLHEHFTACG-IETH-----MYASQWFLTLYTAR 822
             |.....||.    :..:|.||..|::    .|...|  |. :|:.     .:..:|.|..:...
Mouse   482 -DQMHQNFEEQMQGMKTQLIQLSTLLR----LLDSGF--CSYLESQDSGYLYFCFRWLLIRFKRE 539

  Fly   823 FPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQL-----DFEGILKYFRVTLPK------ 876
            |....:..:.:|...: ||......:...:|.||:.:|:     .|..|||:......|
Mouse   540 FSFLDILRLWEVMWTE-LPCKNFHLLLCCAILESEKQQIMAKHYGFNEILKHINELSMKIDVEDI 603

  Fly   877 KCRSS------SQARKVMKQACE 893
            .|::.      :|.:::.:..||
Mouse   604 LCKAEAISLQMAQCKELPQAVCE 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	12/86 (14%)
		TBC	650..858	CDD:214540	54/243 (22%)
		Phage_Gp23	<914..991	CDD:287621
Tbc1d15	XP_006514020.1	DUF3548	10..211	CDD:371881	9/74 (12%)
Tbc1d15	XP_006514020.1	TBC	343..578	CDD:214540	55/247 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810