DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAPcenA and TBC1D15

DIOPT Version :9

Sequence 1:NP_001097549.1 Gene:GAPcenA / 38945 FlyBaseID:FBgn0035879 Length:1194 Species:Drosophila melanogaster
Sequence 2:XP_006719627.1 Gene:TBC1D15 / 64786 HGNCID:25694 Length:699 Species:Homo sapiens


Alignment Length:500 Identity:105/500 - (21%)
Similarity:183/500 - (36%) Gaps:151/500 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   487 ESSKTNLTVAVDIVMRRIQEPVRFVIETPV--TIQSASEMRIMD---------HF--MSKRPMTL 538
            ||.:...|:.|:...:.:.:....:::.|.  .||:.    ::|         |:  :.|.|.|.
Human   193 ESPQDKRTLLVNCQNKSLSQSFENLLDEPAYGLIQAG----LLDRRKLLWAIHHWKKIKKDPYTA 253

  Fly   539 RFYLHLKRTEESNWKVNSIDPSEEITEQ--------------PG---HQQSSSLLKMGMNNLSRI 586
            ......|.|   |:..:|:..|:..|.|              ||   :||.    :.|...::||
Human   254 TMIGFSKVT---NYIFDSLRGSDPSTHQRPPSEMADFLSDAIPGLKINQQE----EPGFEVITRI 311

  Fly   587 VRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNL----A 647
                              ..|:.|::.....||       |:||   .:..|||.|..|:    .
Human   312 ------------------DLGERPVVQRREPVS-------LEEW---TKNIDSEGRILNVDNMKQ 348

  Fly   648 PLVRLGVPEALREKIWQKL-------ANVEGRMEM----NDKY-------KILITKETK------ 688
            .:.|.|:..|||::.|:.|       :..|.|.::    .|:|       |.:..::.|      
Human   349 MIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLR 413

  Fly   689 -CETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEE 752
             ..::|::|::||...:|.::.....|...|..:...|.::|.::||.||:|.:.:.||..|..|
Human   414 DYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENE 478

  Fly   753 -DAFCVLVALMYDYGLRDLYKAGFEV----LYLRLYQLERLIKDQLPKLHEHFTACG-IETH--- 808
             |||....:.|      |.....||.    :..:|.||..|::    .|...|  |. :|:.   
Human   479 VDAFWCFASYM------DQMHQNFEEQMQGMKTQLIQLSTLLR----LLDSGF--CSYLESQDSG 531

  Fly   809 --MYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQL-----DFEGI 866
              .:..:|.|..:...|....:..:.:|...: ||......:...:|.||:.:|:     .|..|
Human   532 YLYFCFRWLLIRFKREFSFLDILRLWEVMWTE-LPCTNFHLLLCCAILESEKQQIMEKHYGFNEI 595

  Fly   867 LKYFRVTLPK------------------KCRSSSQARKVMKQACE 893
            ||:......|                  ||:...||      .||
Human   596 LKHINELSMKIDVEDILCKAEAISLQMVKCKELPQA------VCE 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAPcenANP_001097549.1 PTB_Rab6GAP 204..332 CDD:269922
DUF3694 429..523 CDD:289256 7/37 (19%)
TBC 650..858 CDD:214540 55/243 (23%)
Phage_Gp23 <914..991 CDD:287621
TBC1D15XP_006719627.1 DUF3548 19..227 CDD:192931 5/33 (15%)
TBC 351..586 CDD:214540 56/247 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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