DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAPcenA and Tbc1d1

DIOPT Version :10

Sequence 1:NP_001097549.1 Gene:GAPcenA / 38945 FlyBaseID:FBgn0035879 Length:1194 Species:Drosophila melanogaster
Sequence 2:NP_001297540.1 Gene:Tbc1d1 / 57915 MGIID:1889508 Length:1255 Species:Mus musculus


Alignment Length:1024 Identity:241/1024 - (23%)
Similarity:387/1024 - (37%) Gaps:270/1024 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 SGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGDTT 192
            |||||  ....|.|.:|...:|..:|:...:.:...:|         |.|:  |.|..|      
Mouse   332 SGGGS--GGFHFVCYVFQCTNEALVDEIMMTLKQAFTV---------AAVQ--QTAKAP------ 377

  Fly   193 DEEVSEIDQGCTIFSGVTYL--GAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCSEGL 255
                :::.:||.: .|:..|  ....:|:.|::.|:.:.:..|.:..::...:....:...:|  
Mouse   378 ----AQLCEGCPL-QGLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNE-- 435

  Fly   256 VVLHDAESNTIIA----TYEISSIILYYRG-PVDTVENGCFAFTWLHGDALFQCHVFRC------ 309
                ..|:..||:    .||.......:.| |..|::   .|...:..|.......||.      
Mouse   436 ----QRENELIISFLRCLYEEKQKEHSHTGEPKQTLQ---VAAENIGSDLPPSASRFRLDSLKNR 493

  Fly   310 ---HIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTS------DVSGNPLNTAGYEFI- 364
               .:.|::..:.:...||......|.|..|:|:.....|.||      |....|::...::.: 
Mouse   494 AKRSLTESLESILSRGNKARGLQDHSASVDLDSSTSSTLSNTSKELSMGDKEAFPVSETSFKLLG 558

  Fly   365 ----VSLEIRERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAP 425
                :|.:....:|:.|....|:.  .|:.||||.....:.....|    :|..        .:|
Mouse   559 SSDDLSSDSEGHIAEESALLSPQQ--AFRRRANTLSHFPVECPAPP----EPAQ--------SSP 609

  Fly   426 GKLVVQKDMHLIDMHSMGYIQ---------PGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAF 481
            |  |.|:  .|:..||:....         |||     ||.....|.|:.|........:....|
Mouse   610 G--VSQR--KLMRYHSVSTETPHERNVDHLPGG-----ESQGCPGQPSAPPPPRLNPSASSPNFF 665

  Fly   482 EQLNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKR 546
            :.|...||......||                 |.::...:.:|...|..|..|..|:|   |..
Mouse   666 KYLKHNSSGEQSGNAV-----------------PKSVSYRNALRKKLHSSSSVPNFLKF---LAP 710

  Fly   547 TEESNW------------KVNSI---DPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIE 596
            .:|:|.            |.|.:   |.:...|.:...:|...|               .:|:.:
Mouse   711 VDENNTCDFKNTNRDFESKANHLGDTDGTPVKTRRHSWRQQIFL---------------RVATPQ 760

  Fly   597 DDCPS-----DYSSDGDEPLLSGTGEVSKD----------------------------------- 621
            ..|.|     |||..|:.|..|....|.:|                                   
Mouse   761 KACDSPSRYEDYSELGELPPRSPLEPVCEDGPFGPVQEEKRKTSRELRELWKKAILQQILLLRME 825

  Fly   622 ---------------------------CSQDTLDEWDPILR-------EWDSEKRPKNLAPLVRL 652
                                       |.::....|:.:|.       ::|.||    :...|..
Mouse   826 KENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEK----VHSAVGQ 886

  Fly   653 GVPEALREKIWQKLAN-------VEGRMEMND-KYKILITKETKCETVIQRDIHRTFPAHKCFKE 709
            |||...|.:||:.||.       ...:.:..| .||.|:.|.|..:..|..|:.||||.|..|..
Mouse   887 GVPRHHRGEIWKFLAEQFHLKHPFPSKQQPKDVPYKELLKKLTSQQHAILIDLGRTFPTHPYFSA 951

  Fly   710 IGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAG 774
            ..|:||.:|:.:.|||::.|.||||||||||:|..|||||.||:||.:|..||:|.|||..|:..
Mouse   952 QLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPD 1016

  Fly   775 FEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDG 839
            ..:|.:::|||.||:.|....|:.|.....|...:||:.||||::.::|||.||..|.|:..|.|
Mouse  1017 MIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTVFASQFPLGFVARVFDMIFLQG 1081

  Fly   840 LPVLFQVAVTLL-SICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKI-KKLKQY 902
            ..|:|:||::|| |.....|:..:.|.|:.:.:.|||.  ....|..|.:.|..|..| |:|:.|
Mouse  1082 SEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPN--LGLVQMEKTISQVFEMDIAKQLQAY 1144

  Fly   903 EEEF------------LLKKQHKERLEK--------------EAQIYENRFGEERRKMQAEIDAL 941
            |.|:            |...|..|:|||              :.|:...|.    :.::|.::.|
Mouse  1145 EVEYHVLQEELIESSPLSDNQRMEKLEKTNSSLRKQNLDLLEQLQVANARI----QSLEATVEKL 1205

  Fly   942 NKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQ-------EQDMNTLSET 983
            ....:..|:.|:..|.:.:.::|..:: ::||       |.|...|..|
Mouse  1206 LTSESKLKQAALTLEVERSALLQMVEE-LRRQSARPSTPEPDCTQLEPT 1253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAPcenANP_001097549.1 PTB_Rab6GAP 204..332 CDD:269922 22/143 (15%)
DUF3694 377..523 CDD:463599 31/154 (20%)
TBC 650..858 CDD:214540 91/216 (42%)
SMC_prok_B <876..>1087 CDD:274008 30/142 (21%)
TPH <883..>977 CDD:464007 27/127 (21%)
Tbc1d1NP_001297540.1 PTB 21..150 CDD:269911
PTB_TBC1D1_like 164..365 CDD:269967 10/34 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..544 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..581 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..614 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..681 13/64 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..786 7/21 (33%)
DUF3350 777..832 CDD:463365 4/54 (7%)
TBC 884..1101 CDD:214540 91/216 (42%)
PRK12704 1139..>1239 CDD:237177 21/104 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1233..1255 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

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