DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and TBC1D14

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_011511809.1	Gene:	TBC1D14 / 57533	HGNCID:	29246	Length:	727	Species:	Homo sapiens

Alignment Length:	866	Identity:	186/866 - (21%)
Similarity:	296/866 - (34%)	Gaps:	286/866 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 TDEEVSEIDQGCTIFSGVTYLGA--------------ANINAPKSETEVYRIMGELNSGSKSVGL 242
            ||.::|      |..:||.::|.              .|:.||       |::.....|.|   |
Human     2 TDGKLS------TSTNGVAFMGILDGRPGNPLQNLQHVNLKAP-------RLLSAPEYGPK---L 50

  Fly   243 KITVSIPNCSEGLVVLHDAES-NTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDALFQCHV 306
            |:        ..|...|..:| ::.|.|.||.:     ..||.     |.|           .||
Human    51 KL--------RALEDRHSLQSVDSGIPTLEIGN-----PEPVP-----CSA-----------VHV 86

  Fly   307 FRCH-----IPEAVNQVSACFQKAFQTYPPSM-------------------SCSLNSAVDMANSV 347
            .|..     |||...| |||...:.....||.                   |..|.|....|.:.
Human    87 RRKQSDSDLIPERAFQ-SACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTR 150

  Fly   348 TSDVSGNPLNTAGYEFIVSL-----EIRERVAKNSYAAVPRDRGCFKLRANTDKE----VCITVK 403
            :.|||...:::.|.|...:|     :|.:.|..:|.:|:      ..|..:.|.:    ...::|
Human   151 SDDVSVCSVSSLGTELSTTLSVSNEDILDLVVTSSSSAI------VTLENDDDPQFTNVTLSSIK 209

  Fly   404 QTPSNVLQPLHIERCFGVLVAPGK--------------LVVQKDMHLIDMHS-MGYIQPGGTGVA 453
            :|     :.||.:.|........|              |:.:|....:|.|: :|:...|...:.
Human   210 ET-----RGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQSARLDKHNDLGWKLFGKAPLR 269

  Fly   454 TESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTI 518
                .|||:.|.     |.:.:.::||.......|.|.|:...:|.      ||    :.|...|
Human   270 ----ENAQKDSK-----RIQKEYEDKAGRPSKPPSPKQNVRKNLDF------EP----LSTTALI 315

  Fly   519 QSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQ--SSSLLKMGMN 581
                        :..||..|                    |::...|...|:|  ...:::....
Human   316 ------------LEDRPANL--------------------PAKPAEEAQKHRQQYEEMVVQAKKR 348

  Fly   582 NLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNL 646
            .|....|...  .:|:.|..:.|          .|......:.:.|..|:.:   |.|.|    :
Human   349 ELKEAQRRKK--QLEERCRVEES----------IGNAVLTWNNEILPNWETM---WCSRK----V 394

  Fly   647 APLVRLGVPEALREKIWQ-KLANVEGRMEMN--------------DKYKILITKETKCET----- 691
            ..|...|:|.::|.|:|. .:.|     |:|              ::::.|.|..::.|.
Human   395 RDLWWQGIPPSVRGKVWSLAIGN-----ELNITHELFDICLARAKERWRSLSTGGSEVENEDAGF 454

  Fly   692 ----------VIQRDIHRTFP-----------------AHKCFKE----------------IGGS 713
                      :|:.||.||||                 ..|.|::                :||.
Human   455 SAADREASLELIKLDISRTFPNLCIFQQVLIFVDFRVGLQKSFQKRKERESTKLQQLWSWCLGGP 519

  Fly   714 GQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAF----------CVLVALMYDYGLR 768
            ..|.|..:..||..:..:|||.||:|||||.|:|::...|||          |.:.....|:||.
Human   520 YHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLM 584

  Fly   769 DLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLD 833
            ..|.|.|||.:          ::.||||..||....:...:|...|..|||:...||.....:.|
Human   585 LTYFAAFEVFF----------EENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWD 639

  Fly   834 VFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKIKK 898
            ||..||...||:.|:.:|.:.|..|.::||..:.: |...||:...:......:.....:.:.||
Human   640 VFCRDGEEFLFRTALGILKLFEDILTKMDFIHMAQ-FLTRLPEDLPAEELFASIATIQMQSRNKK 703

  Fly   899 LKQYEEEFLLKKQHKERLEKE 919
            ..|     :|....|:..|.|
Human   704 WAQ-----VLTALQKDSREME 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	33/147 (22%)
		DUF3694	429..523	CDD:289256	20/94 (21%)
		TBC	650..858	CDD:214540	73/280 (26%)
		Phage_Gp23	<914..991	CDD:287621	2/6 (33%)
TBC1D14	XP_011511809.1	TBC	398..664	CDD:214540	73/280 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810