DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and tbc1d12a

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_021330042.1	Gene:	tbc1d12a / 563626	ZFINID:	ZDB-GENE-030131-3920	Length:	823	Species:	Danio rerio

Alignment Length:	932	Identity:	192/932 - (20%)
Similarity:	303/932 - (32%)	Gaps:	314/932 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EAGGDR-SPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLP-----SHQQKSLTL 123
            :||..: :|.:|:..||.    :|:......|.:..|      |.|....|     ...|::|:.
Zfish     6 DAGEPKLAPFIDVNDNRE----EHKARVCGSDTDGAR------EGSVYISPYADPGGAGQQTLSS 60

  Fly   124 PLTGSGGGSVD---PEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDA-- 183
            .|||...|.::   .::...|    |..||  :..|.:.||..:..          .|:|.|.
Zfish    61 VLTGCKAGVLNGFLEQLDMVC----PDGEE--ETQSDTGRVSGTFE----------TEDKPDKAY 109

  Fly   184 ------------------MKPEKGDTTDEEV---------------------SEIDQGCTIFSG- 208
                              ||...||.|.|.:                     :.:|:|..:.:|
Zfish   110 LNSQMRSAVSFMGKTSPDMKIPNGDVTHEHMDHDQTQLRCLNYTEGFNRKASAALDRGVKVGNGG 174

  Fly   209 ------------VTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCSEGLVVLHDA 261
                        |.:.....:.||:....|::..|.|:||....    .||.|:..|.    |..
Zfish   175 LLIVNSYDTLSQVPFGALGGLPAPERPVFVHQSDGVLSSGRSCE----RVSHPSADEA----HLC 231

  Fly   262 ESNTIIATYEIS---SIILYYRGPVDTVENGCFAFTWLHGDALFQCHVFRCHIPEAVNQVSACFQ 323
            :.:.:....::|   |:........|..|..                      |......|
Zfish   232 DPDPVYTLTDLSTKLSLSPLAENTSDYTETD----------------------PSPEEDFS---- 270

  Fly   324 KAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPRDRGCF 388
               .|.||....:|.:......|::.|.:  ||:                        |.|.|.|
Zfish   271 ---DTGPPVRPQNLRTNPGHPISLSCDAT--PLS------------------------PEDDGYF 306

  Fly   389 KLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVA 453
            ......|:  |::...|...|.:.          .||.:  |..|.:.....::|..:.|.....
Zfish   307 GAEGCVDE--CLSSGNTFEGVRRQ----------SAPDR--VDVDPNASSDQTLGTKRHGIADFL 357

  Fly   454 TES-------DSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMR---RIQEPV 508
            |.|       :|.|..|.|.|     .||...|.  ||.....|.:.|:..:...|   ....|
Zfish   358 TRSLFSWKPKESRAVASHSAP-----GWKLFGKI--QLRDNPLKDSRTIQQEYESRAGPATGPP- 414

  Fly   509 RFVIETPVTIQSASEMRIMDH---FMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQ 570
               :..|.|.:...|...:..   .:..||..|                    |::...|...|:
Zfish   415 ---LHPPPTRRKNLEFEPLSTTALILEDRPANL--------------------PAKSEEESQRHR 456

  Fly   571 QSSSLLKMGMNN-------------LSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDC 622
            |..|.:..|...             ..|..:..:|||
Zfish   457 QEYSEMVAGAKRREMKEAQKKKRQMKERYRQEENIAS---------------------------- 493

  Fly   623 SQDTLDEWD-PILREWDSEKRPKNLAPLVRLGVPEALREKIW-QKLANVEGRMEMN---DKYKIL 682
               .:..|: .:|..|:|.:..:.:..|...|||.::|.|:| ..:.|     |:|   :.|:|.
Zfish   494 ---AMVIWNSEVLPNWESMRNTRRVRDLWWQGVPPSVRGKVWCLAIGN-----ELNITPELYEIF 550

  Fly   683 ITKETK-----CET---------------------VIQRDIHRTFPAHKCFKEIGGSGQDALFKV 721
            :::..:     .||                     :|:.||.||||:...|:: ||...|.|..|
Zfish   551 LSRAKEKWRSFSETSSVNENEDCGVSLADRESSLDLIKLDISRTFPSLYIFQK-GGPYHDILHSV 614

  Fly   722 SKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAF----------CVLVALMYDYGLRDLYKAGFE 776
            ..||..:..:|||.||:|||||.|:|::.|.|||          |.:.....|:.|...|.|.||
Zfish   615 LGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQMAFFRVDHDLMLKYFAAFE 679

  Fly   777 VLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLP 841
            |.:          ::.||:|.:||....:....|...|..|||:...||.....|.|||..||..
Zfish   680 VFF----------EENLPRLFQHFQNNSLTPDFYLIDWIFTLYSKSLPLDVACRVWDVFCRDGEE 734

  Fly   842 VLFQVAVTLLSICESDLRQLDF 863
            .||:..:.:|.:.:..|.|:||
Zfish   735 ALFRTGLGILRLYQDVLLQMDF 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	22/143 (15%)
		DUF3694	429..523	CDD:289256	22/103 (21%)
		TBC	650..858	CDD:214540	73/247 (30%)
		Phage_Gp23	<914..991	CDD:287621
tbc1d12a	XP_021330042.1	TBC	519..752	CDD:214540	73/248 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910