DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and usp6nl

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_005164934.1	Gene:	usp6nl / 561983	ZFINID:	ZDB-GENE-041210-192	Length:	849	Species:	Danio rerio

Alignment Length:	558	Identity:	124/558 - (22%)
Similarity:	218/558 - (39%)	Gaps:	84/558 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 EVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANV----EGRMEMND 677
            |..|....:...:|..:|:.|:..|....|...:..|:|..||.::|..|.::    |.:.:..:
Zfish    87 EKQKQLEVERTTKWLKMLKSWEKYKNSDKLVRRIYKGIPLQLRGQVWCLLLDIPKIKEEKKDFYE 151

  Fly   678 KYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIA 742
            |.||.....:.....|..|::||:..|..|.......|..||.|..||:|:::|||||||:|.|.
Zfish   152 KLKIRARGLSPDVRQIDLDVNRTYRNHIMFMHRYDVKQQDLFHVLTAYSVYNTEVGYCQGMSQIT 216

  Fly   743 ASLLLHMPEEDAFCVLVALM--YDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGI 805
            |.||::|.|||||..||.|:  ..:.:...:..||..|.......:|:::..:|||.:|.....:
Zfish   217 ALLLIYMNEEDAFWALVKLLSGQRHTMHGFFVPGFPKLMRFQEHHDRILQKMMPKLKQHLDNQEV 281

  Fly   806 ETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYF 870
            .|.:|..:||...:..|.|......:.|:::|:|..||..::.|:|.:.:..|.:|..|.::|:.
Zfish   282 YTSLYTMKWFFQCFLDRTPFTLTLRIWDIYILEGERVLTAMSYTILKLHKKTLLKLSMEELVKFL 346

  Fly   871 RVTLPKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQ 935
            :|||....                      .:|::|::     |:|:...        .|.|:.:
Zfish   347 QVTLSNDF----------------------FFEDDFVI-----EQLQNSM--------SELRRSK 376

  Fly   936 AEIDALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQ 1000
            .|:....|:....|:...:...:..|:                     .....:.|:|.|...|.
Zfish   377 LELPPPGKEDEYPKKPLGQLPPEPPGL---------------------AAAATNHVANGQPVGQT 420

  Fly  1001 ID---------AGNDNAKSDDGKNRGQTDAM--RNANEHPLGPLDPLNAASQRIRELELELAQAK 1054
            .:         |.:.|.:.|.|.   .||..  |..:..|...||..:...:..|:.....|..:
Zfish   421 GEGLPPRGPSPAVSVNKRVDSGP---VTDGTPERYQDSRPPSSLDKFHHPDKIERDRRGVYANKE 482

  Fly  1055 LAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQ--EKVTTRGGHRDNGSGGP--- 1114
            ...|..:...|:..:..||..|.::  |.....|:..:...|:  :....|.......:|.|
Zfish   483 RVPVGGKASTQNQANHNSNARSSMR--REIGPRWVKPSEGKLEAVKAAALRESQLSLATGVPPSP 545

  Fly  1115 -MPSFQSYMGQAPTTLSEASSPSGNQEYKTFAFASVGG 1151
             .|:.....|......|.|.:|..|:......:.:|.|
Zfish   546 SSPTPDEATGAQRRPRSRAFAPGSNRASNASQYDNVPG 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	65/213 (31%)
		Phage_Gp23	<914..991	CDD:287621	8/76 (11%)
usp6nl	XP_005164934.1	TBC	120..326	CDD:214540	63/205 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810