DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and tbc1d2

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_689604.6	Gene:	tbc1d2 / 561110	ZFINID:	ZDB-GENE-140106-100	Length:	926	Species:	Danio rerio

Alignment Length:	970	Identity:	188/970 - (19%)
Similarity:	325/970 - (33%)	Gaps:	320/970 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 YRIMGELNSGSKSVGLKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCF 291
            ||:..::||..|....:.|.|.|        |...|....|.|.|.:.|:        ...|...
Zfish    89 YRMAHDINSLGKVDLTRATFSYP--------LRGEEGTFHIQTPERTVIL--------KAANRDA 137

  Fly   292 AFTWLHGDALFQCHVFRCHI------------PEAVNQVSACFQKAFQTYPPSMSCSLN------ 338
            ...||.     |..:.|...            |:::...|.         ||:.:|..|
Zfish   138 QMYWLQ-----QLQLKRAQFRDQQAEHQSTPRPDSLTTEST---------PPANNCPANFLPMVK 188

  Fly   339 --SAV--DMANSVTSDVSGNPLNTAGYEFIVSL-------------EIRERV------------- 373
              |.:  :.|.|:.:....||||.:....::.|             |||:.|
Zfish   189 TPSGLVGEEAASLPAPGLNNPLNMSIKHPLIELQNTMHSFRNRQSQEIRQSVFHIDDPGDTQKTT 253

  Fly   374 ----------AKNSYAA-------------------VPRDRGCFKLRA----------------- 392
                      |..||.|                   :.::|...|.|:
Zfish   254 SPKTSTLVVPATTSYQAPESPVKAKCEDPHQNNISTISQNRKSGKERSRFLDLKDTSQLQHEKLS 318

  Fly   393 -----NTDKEVCITVKQTPSNVLQPLHIER--CFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGT 450
                 ...||:.:.:.:    ||:...:|:  |...|.|.|:   |:.|.|: .|  |..:....
Zfish   319 LAEEVKAQKELVLLLHK----VLEAAQLEKRTCAQFLAAEGE---QERMELL-RH--GERRAAEL 373

  Fly   451 GVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDI--VMRRIQEPVRFV-- 511
            .|..|:.....::.....|.|.|..|:.:...||.|:.::|...|.:.:  .:....|..::.
Zfish   374 RVQLEALQQENENLRRDLTQRDEHVAELQNSIQLLLQKNQTKQEVILKLSEKLTTCGEDQQYTNG 438

  Fly   512 IETPVTIQSASE----------MRIMDHFMSKR--PMTLRFYLHLKR----------TEESNWKV 554
            :|:....|...|          ..|.:.:::..  .:|:.:....:|          .|.:|.::
Zfish   439 LESETFRQMTMENEQLKDDLKAYNIQNQYLNSEIYQLTMLWRKSSEREKSLIVKCAVLEANNCQM 503

  Fly   555 NS--------IDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDG---- 607
            .|        :..|:|:..:.....:..|......:|:..::.:.|        |||...|
Zfish   504 ESRYLGILQKLQESQELNPEQREAVNKMLKDAVQADLNNAIKLNPI--------SDYDEYGFRIA 560

  Fly   608 ------DEPLLSGTGEVSKDCSQDTLDEWD---PILR------------EWDSEKRPKNLAPLVR 651
                  |..||:.. :..:..||:.|::.:   |:|.            |..|....|.   |:|
Zfish   561 VDYKVEDLKLLAKI-QALEFRSQNLLNQEECDGPLLARCAQLLFGRPEGELTSSAEMKG---LLR 621

  Fly   652 LGVPEALREKIWQKLANVEG---RMEMNDKYKILITKETKCETV----IQRDIHRTFPAHKCFKE 709
            .|:|...|.::|:.:.....   |....|:|..|..|......:    ||.|:.||..::|.|..
Zfish   622 TGLPHEYRVRVWRFMIQTRTKSLRERHPDRYHELCEKSRSSPHLVPRQIQLDLDRTLTSNKHFSP 686

  Fly   710 IGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEE-DAFCVLVALMY-----DYGLR 768
            ........|.:|.:|::.|:..:||.|||:.:||..||.:.|| |||..||.::.     :|..:
Zfish   687 PTSPLIQKLERVLQAFSWHNPTIGYVQGLNRLAAIALLVLQEEADAFWCLVVIVEHIMPPNYFTK 751

  Fly   769 DLYKAGFEVLYLRLYQLERLIKD----QLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVF 829
            ||.....:         :|::||    :||:|..|..|..::..:...:|||.|:....|...:|
Zfish   752 DLVGCQAD---------QRVLKDLMLEKLPRLTAHLEALKVDISLITVEWFLVLFVESLPTRILF 807

  Fly   830 HVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACER 894
            .|.|..|.:|..|:|:.|:.|.
Zfish   808 KVWDALLYEGSKVIFRYALALF------------------------------------------- 829

  Fly   895 KIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDALN--KQLTSAKERAVEKEK 957
                  :|.||.:||.|....:.:..:|:.|...:.|:......:.:|  :.......||...|:
Zfish   830 ------KYREEAILKIQDSVEMYQYLRIFPNTIADGRKLTSIAFNDMNPLRMRLIQNRRAAHLER 888

  Fly   958 KHTGIIQEYKQIIQRQEQDMNTLSETLGKV-----MHMVSNCQDCQQQIDAGNDNAKSDD 1012
            .|.    |.|::            |.|.|.     :|    |:|.:.      |:..|||
Zfish   889 LHA----EIKEL------------ENLQKAYKAERVH----CKDKKL------DSLASDD 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	22/116 (19%)
		DUF3694	429..523	CDD:289256	19/97 (20%)
		TBC	650..858	CDD:214540	62/224 (28%)
		Phage_Gp23	<914..991	CDD:287621	14/83 (17%)
tbc1d2	XP_689604.6	PH	56..146	CDD:278594	18/77 (23%)
		PH_TBC1D2A	57..153	CDD:269966	19/84 (23%)
		TBC	621..837	CDD:214540	65/273 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810