Protein Alignment GAPcenA and rabgap1

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: XP_073770556.1
• Gene: rabgap1 / 559632
• ZFINID: ZDB-GENE-170622-1
• Length: 1076
• Species: Danio rerio
• Alignment Length: 1199
• Identity: 426/1199 - (35%)
• Similarity: 617/1199 - (51%)
• Gaps: 238/1199 - (19%)

  Fly     3 DNLSTKSSESSITTSGEYEIVTDSNVASPMEQV-KQVVNQEGTQPEVGGKPPTSLSALALSSPEA 66
            |::||.:||..:..|...:....:|..|..|:. .:|:::||...::.|
Zfish    15 DSVSTLNSEDFVLVSRLGDETPSTNNGSDDEKTGLKVISEEGVSFKIVG---------------- 63

  Fly    67 GGDRSPTLDMAHNRNLSDMQHEMTDALKD---LELERGVAASGEKSAQRLPSHQQKSLTLPLTGS 128
                        |.:...:|.|:.|.|.|   .||..|....|:      ..|...:..:|   |
Zfish    64 ------------NGSEQQLQQELEDVLMDPSVTELVVGPDHLGQ------GDHGYPTTAVP---S 107

  Fly   129 GGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGDTTD 193
            ..|||.|::.....: ....|..|::.|..:...        |.||......:|::
Zfish   108 RSGSVPPKLEIVLPI-QGAQESELNERSYRDEPS--------DLSPGTPVPDEDSV--------- 154

  Fly   194 EEVSEIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCSEGLVVL 258
                       :||.:||||.|::|||:||.|..|::..|.|..: :.|.:|:|:|..|||.|.|
Zfish   155 -----------VFSKLTYLGCASVNAPRSEVEALRMVSILRSQCQ-MPLDVTLSVPGVSEGTVRL 207

  Fly   259 HDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLH-GDALFQCHVFRCHIPEAVNQVSACF 322
            .|.:|:|.||.|.|..|:...||...|.|:.|||||..| ...:|:.|||||.|.|||:::...|
Zfish   208 LDPQSSTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNTEIFRIHVFRCEIQEAVSRILYSF 272

  Fly   323 QKAFQTYPPSMSCSLNSA--VDMANSVT--SDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAV-- 381
            ..||:.       |.|.|  ...|..:|  |||         :.|.|||||:|...|.:::||
Zfish   273 ATAFRR-------SANKAPLATKAPPLTPDSDV---------FTFTVSLEIKEDDGKGTFSAVSK 321

  Fly   382 PRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQ 446
            .:||..|||||..||::.|.|:|| ||  :.|.||||||:|::|||.|...||||:|:.|||
Zfish   322 DKDRQSFKLRAGMDKKIVIYVQQT-SN--KELAIERCFGLLLSPGKNVKNSDMHLLDLESMG--- 380

  Fly   447 PGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN---LTVAVDIVMRRIQEPV 508
                          :.|....|.|...|......|:.:|.|:.|..   :|.|||:|:..::|||
Zfish   381 --------------KSSDGKSYIITGSWNPNTPQFQAVNEETPKDKFMYMTTAVDLVITEVEEPV 431

  Fly   509 RFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNS-----IDPSEEITEQPG 568
            ||::||.|.:.|.:| |:...| |||..|..|||.|::.|....|.||     :...|..||:..
Zfish   432 RFLLETRVRVCSPNE-RLFWPF-SKRSYTETFYLKLRQMENKERKSNSDTLYEVMSLESETERER 494

  Fly   569 HQQSSS--LLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWD 631
            .:.::|  :|..|.:       .|::.|..:|   |...|.|||||||:|:|||:|::..|:.|.
Zfish   495 RKTTASPGVLSSGSH-------GSTVPSPPED---DEEEDNDEPLLSGSGDVSKECAEKILETWG 549

  Fly   632 PILREW--DSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVIQ 694
            .:|..|  :...|||.|..|||.|||||||.::||.||.......:.::|:.|||||:..::.|.
Zfish   550 ELLSRWHLNLAVRPKQLPALVRSGVPEALRGEVWQLLAGCHNNDHLVEEYRTLITKESPQDSAIT 614

  Fly   695 RDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLV 759
            |||:||||||..||:.||.|||:|:|:.|||:|:|.|:|||||.||:||.||||||||.||.|||
Zfish   615 RDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLV 679

  Fly   760 ALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFP 824
            .:|::||||:|:|..||.|:.:.:|||||:::.:|.|:.||...|:|.|||||||||||:||:||
Zfish   680 KIMFEYGLRELFKQNFEDLHCKFFQLERLMQECIPDLYTHFLNLGLEAHMYASQWFLTLFTAKFP 744

  Fly   825 LCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMK 889
            |..|||::|:.|.:|:.|:|.||::||...:.||.|.||||.||:|||.:||:.||...|:|:|:
Zfish   745 LYMVFHIIDLLLCEGISVIFNVALSLLKTSKDDLLQTDFEGALKFFRVPVPKRYRSEENAKKLME 809

  Fly   890 QACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEI-------------- 938
            .||..||  ||||:||:|:...::.:|:.|...:.||.   |.||..:|.:
Zfish   810 LACSMKISQKKLKKYEKEYHTIREQQEQQEAPIERYER---ENRRLQEANMRLEQENDDLAHELV 871

  Fly   939 -----------------DALNKQLTSAKERAVEKE----------------------------KK 958
                             |||||:|...|::.||.|                            ||
Zfish   872 SSKIALRKDLDNAEEKADALNKELLITKQKLVESEDEKRRLEEESAQLKEMCRRELDKSESEIKK 936

  Fly   959 HTGIIQEYKQII----QRQEQDMNTLSETLGKVMHMVSNCQDCQ---------QQIDAGNDNAKS 1010
            :..||.|||||.    :|.|:...:....|.|:...|..|:.|.         :.:.|..:.::.
Zfish   937 NGSIIGEYKQICSQLSERLEKQQTSNRGELEKIRMKVEGCEKCSNLFSKEGRLKVLSAPKEGSEE 1001

  Fly  1011 DDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSNTL 1075
            |..:.:   :|::|                 ::||:||||||.||..||||||.|||.|.|...|
Zfish  1002 DTDEEK---EALKN-----------------QLREMELELAQTKLQLVEAECKIQDLEHHLGLAL 1046

  Fly  1076 SELQTNRNSWQPWLSKTFNSLQEKVTTRG 1104
            :|:|..:.:   |.::|.:|::.....:|
Zfish  1047 NEVQAAKKT---WFNRTLSSIKTVTGAQG 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	56/128 (44%)
		DUF3694	377..523	CDD:463599	59/150 (39%)
		TBC	650..858	CDD:214540	115/207 (56%)
		SMC_prok_B	<876..>1087	CDD:274008	79/284 (28%)
		TPH	<883..>977	CDD:464007	43/158 (27%)
rabgap1	XP_073770556.1	None