DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and tbc1d14

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_005166496.1	Gene:	tbc1d14 / 557744	ZFINID:	ZDB-GENE-030131-6136	Length:	711	Species:	Danio rerio

Alignment Length:	688	Identity:	157/688 - (22%)
Similarity:	244/688 - (35%)	Gaps:	192/688 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 HIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIR--ER 372
            |:|.             .|.||::|.|..|......:...|.|......:|   |.:|||.  |.
Zfish    50 HVPS-------------DTQPPNVSLSCKSFTSFNGTCEEDRSSLGSQDSG---IPTLEINPPEH 98

  Fly   373 V-AKNSYAAV----PRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQK 432
            : |:.:.|.:    |.|          |....:.:..:..::|:.....||
Zfish    99 IHARVTIAELVVPPPHD----------DNPATLNLDISDGSLLKSSTFPRC-------------- 139

  Fly   433 DMHLIDMHS-MGYIQPGGTGVATESD-----SNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKT 491
            |..|:..:. .|.....|.|....||     |.:..|:.:..|:..   :.|...:.:....|..
Zfish   140 DFDLVRHYGPSGLSSAAGKGTLNRSDDISVCSVSSLSTEFSTTLSV---SNEDFLDFMVTSESSA 201

  Fly   492 NLTVAVDIVMRRIQEPVRFVIE----------TPVTIQSASEMRIMDHFMSKR--PMTLRFY--L 542
            .:|...:.|:.|....:...|:          .||.:..|.|.|      .||  |:...|.  |
Zfish   202 VVTFENEDVLHRFDSSLSAPIDLHGKLSSPQRQPVGVSGAHEAR------PKRLGPLASFFNRGL 260

  Fly   543 HLKRTE---------ESNWKV------------NSIDPSEEITEQPGHQQSSSLLKMGMNNLSRI 586
            ..||.:         |..||:            :|....:|...:.||..:|:..|..:......
Zfish   261 FAKRMKDTGALEGQREPGWKLFGKVPHKDLPTKDSRKLQKEYERRSGHTSNSTSPKKNVRKNLDF 325

  Fly   587 VRSSSIASIEDDCPSDYSSDGDE-----------------------------------PLLSGTG 616
            ...|:.|.|.::.|::..:..:|                                   .|....|
Zfish   326 EPLSTTALILENRPANLPAKPEEEAQKHRQQYEEMVAQAKKRELKDAQKRKKQLEDRCKLEESIG 390

  Fly   617 EVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDK-YK 680
            ..:...||:       ||..|.|....|.:..|...|:|.::|.|:| .|| :...:.:.|: |.
Zfish   391 NAALTWSQE-------ILPNWQSMCSSKRVRDLWWQGLPPSVRGKVW-SLA-IGNELNITDELYD 446

  Fly   681 ILITK---------------ETKCE-------------TVIQRDIHRTFPAHKCFKEIGGSGQDA 717
            |.:.:               ||:.|             .:|:.||.|||| :.|..:.||...|.
Zfish   447 ICLARAKEKWNAFVAPTAAVETESEDAGLSHADREASLELIKLDISRTFP-NLCIFQKGGPYHDV 510

  Fly   718 LFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAF----------CVLVALMYDYGLRDLYK 772
            |..:..||..:..:|||.||:|||||.|:|::...|||          |.:.....|:.|...|.
Zfish   511 LHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFANLLNKPCQMAFYRVDHSLMLTYF 575

  Fly   773 AGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLL 837
            |.|||.:          ::.||||..||....:.:.:|...|..|||:...||.....|.|||..
Zfish   576 AAFEVFF----------EENLPKLFAHFKNNNLSSDIYLIDWIFTLYSKSLPLDIACRVWDVFCR 630

  Fly   838 DGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLP 875
            ||...||:.|:.:|.:.|..|..:||..|.: |...||
Zfish   631 DGEEFLFRTALGILRLYEDILTHMDFIHIAQ-FLTRLP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	4/21 (19%)
		DUF3694	429..523	CDD:289256	19/109 (17%)
		TBC	650..858	CDD:214540	74/246 (30%)
		Phage_Gp23	<914..991	CDD:287621
tbc1d14	XP_005166496.1	COG5210	293..656	CDD:227535	96/382 (25%)
tbc1d14	XP_005166496.1	RabGAP-TBC	485..651	CDD:278964	61/176 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810