DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and tbc1d25

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001121708.1	Gene:	tbc1d25 / 556338	ZFINID:	ZDB-GENE-041111-25	Length:	863	Species:	Danio rerio

Alignment Length:	764	Identity:	163/764 - (21%)
Similarity:	285/764 - (37%)	Gaps:	174/764 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 FEQLNLESSKTNLTVAVDIVMRRIQ------------EPVRFVIETPVTIQSASEMRIMDHFMSK 533
            |....::...|:|.|...|::|..:            ...|..:|..|::  .|:..:...|:|.
Zfish    25 FRSFAVDPQITSLEVLQHILIRAFELNGKRNFGISYLSRDRAGVEVYVSL--LSDWDLDAAFVSA 87

  Fly   534 RPMTLRFYLHLKRTEES----NWKVNSIDPSEEI--TEQPGHQQS---------SSLLKMGMNNL 583
            ....|:..:.:|.:|:|    :|.:  |.|.:.|  .:..|.::|         .|||......|
Zfish    88 AKPYLQLKMDIKPSEDSPVLEDWDI--ISPKDVIGSDQLQGEKRSLASAALPFTQSLLSQVGRTL 150

  Fly   584 SRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNLAP 648
            ||:.::.|.:..|:..|.       :|.||..             |:...|.......||:.|.
Zfish   151 SRVQQALSWSYGEEVKPF-------KPPLSDA-------------EFHNYLNSQGQLSRPEELR- 194

  Fly   649 LVRL---GVPEALREKIWQKLANV-----EGRMEMN---------DKYKILITKETKCETV---- 692
             :|:   ||..:||:.:|:.|.||     .|:..|:         |:.|...|.....|.:
Zfish   195 -LRIYHGGVESSLRKVVWRYLLNVYPDGLTGQERMDYMKRKTREYDQLKSEWTARVSSEELEFIR 258

  Fly   693 --IQRDIHRTFPAHKCFKEIGGSGQD----ALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPE 751
              :.:|:.||..||..:   .||...    ||..:...:|:...:|.||||:|.||:.:|..|..
Zfish   259 GNVLKDVLRTDRAHPYY---AGSEDSPHLTALTDLLTTFAITHPQVSYCQGMSDIASPILAVMDN 320

  Fly   752 E-DAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWF 815
            | .||.....:|  ..|...::...:::.::...|:.|::...|:.:.:..:.|.:...:..:|.
Zfish   321 EAHAFICFCGIM--KRLEGNFRPDGQLMSIKFQHLKLLLQYSDPEFYSYLVSKGADDLFFCYRWL 383

  Fly   816 LTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLS-ICESDLRQLDFEGILKYFRVTLPKKCR 879
            |......|.......:|:|......|...:..|.||. ..|:|
Zfish   384 LLELKREFAFDDALRMLEVTWSSLPPDPPETEVELLGPAFEAD---------------------- 426

  Fly   880 SSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKER-LEKEAQIYENRFGEERRKMQAE------ 937
            .|..:..|..:..|.     ||.|.:   :::|..| ..:||....|...||.|..:.|
Zfish   427 QSDGSHNVDMEEMEE-----KQTERQ---RRRHMLRPSREEADGERNLVMEEERGPRKEGEGEYD 483

  Fly   938 IDALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDM----NTLSE-TLGKVMHMVSNCQDC 997
            ::::.:....|:..:.||:    |...|:|....|.|...    |..|: ||..|....:: ...
Zfish   484 VESMVRNDIPAQPPSFEKQ----GSFGEFKYYNGRTEDSFEVNENDSSDPTLSPVQFQSAH-STL 543

  Fly   998 QQQIDAGNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAEC 1062
            ...:....:.::.|.|:            :.||  ::.|..:|...|:.....|.:.|:.:.:..
Zfish   544 PFSVRQSTEESEDDPGE------------QEPL--INNLTPSSPGQRDSPNGQAASPLSTLPSGL 594

  Fly  1063 KN-QDLNHQLSNTLSELQTNRNSWQ----PWLSK--TFNSLQEKVTTRGGHRDNGSGG---PMPS 1117
            .| :..::|.||:.|       ||:    ..|||  :.:|..||..:    .|..|||   ..|.
Zfish   595 PNWKSSSNQSSNSAS-------SWRTASPDALSKCTSSSSSGEKALS----PDKPSGGFASSQPV 648

  Fly  1118 FQSYMGQAPTTL---SEASSPSG--NQEYKTFAFASVGGSPKLPSKFQA 1161
            ......|:|:.:   |..:|||.  |....:....|.|.||.||..|.:
Zfish   649 LNGTGAQSPSVVPGKSLLASPSQGYNHSLLSSPVLSFGKSPSLPKAFSS 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	9/53 (17%)
		TBC	650..858	CDD:214540	54/236 (23%)
		Phage_Gp23	<914..991	CDD:287621	21/88 (24%)
tbc1d25	NP_001121708.1	TBC	198..420	CDD:214540	51/226 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900