DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and TBC1D2

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001254500.1	Gene:	TBC1D2 / 55357	HGNCID:	18026	Length:	928	Species:	Homo sapiens

Alignment Length:	940	Identity:	182/940 - (19%)
Similarity:	311/940 - (33%)	Gaps:	336/940 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 YEISSIILYY------RGPVDTVENGCFAFTWLHGDALFQCH------VFRCHIPEAVNQVSACF 322
            |:.....|||      ..|:|:::         ...|:|.|.      :|....|..|..:.|..
Human    71 YDERKCQLYYSRTAQDANPLDSID---------LSSAVFDCKADAEEGIFEIKTPSRVITLKAAT 126

  Fly   323 QKA--------------FQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERV 373
            ::|              |...||:...:.::|:                 ||...::.||:.:.
Human   127 KQAMLYWLQQLQMKRWEFHNSPPAPPATPDAAL-----------------AGNGPVLHLELGQE- 173

  Fly   374 AKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNV-----LQPL---------HIERCFGVLVA 424
                             .|..::.:| .||..|..|     |||.         |:
Human   174 -----------------EAELEEFLC-PVKTPPGLVGVAAALQPFPALQNISLKHL--------- 211

  Fly   425 PGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSNAQ---------------------------- 461
              ...:|..||.|    .|..|..|||.....:.:.|
Human   212 --GTEIQNTMHNI----RGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKP 270

  Fly   462 ----------------QSSSWPY-----------------------TIRAEWKAQE-------KA 480
                            |::::|:                       .:..|.|:|:       ||
Human   271 APKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKA 335

  Fly   481 FE--QLNLESSKTNLTVAVD-IVMRRIQEPVRFVIETPVTIQSASEMR-IMDHFMSKRPMTLR-F 540
            .|  |....:|...|..|.| ..:..::..||.:.|....:::..:.| .:.|..|.|...:: .
Human   336 LEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQEL 400

  Fly   541 YLHLKRTEESNWKVNSI--DPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDD----- 598
            ..|::...:.|.....:  ..||::|:...|....|.|:....|...:.:...|..::||
Human   401 QQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYR 465

  Fly   599 --------------------------------------C--PSDYSSDGDEPLLSGTGEVSKDCS 623
                                                  |  .|.|.: |...|....|:.:.:||
Human   466 TQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLA-GLRRLQEALGDEASECS 529

  Fly   624 -------QDTLDEWD-------------------------------------------------- 631
                   |:.| :|:
Human   530 ELLRQLVQEAL-QWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLL 593

  Fly   632 -------PILREWDS--EKRPK-NLAPLVRLGVPEALREKIWQKLANVE-GRMEMNDKYKILIT- 684
                   |:...|.:  :..|. .|..|:|.|||...|.::|:.|.::. ..:.....|:.|::
Human   594 GLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSR 658

  Fly   685 ---KETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLL 746
               :|......|:.|::||||.:|.|.....|..|.|.:|..|::..:..:||||||:.:||..|
Human   659 GQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIAL 723

  Fly   747 LHMPEED-AFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMY 810
            |.:.||: ||..|||::......|.|........:....|:.|:.::||:|..|.....::..:.
Human   724 LVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLV 788

  Fly   811 ASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGI-----LKYF 870
            ...|||.::........:..|.|.||.:|..|:|:.|:.:....|.::.:|. .|:     |::|
Human   789 TFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQ-NGLEIYQYLRFF 852

  Fly   871 RVTLPKKCRSSSQARKVMKQACER----KIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGE-- 929
            ..|:       |.:||:|..|...    ::|:|:|      |:..|:||||.|.:..|....|
Human   853 TKTI-------SNSRKLMNIAFNDMNPFRMKQLRQ------LRMVHRERLEAELRELEQLKAEYL 904

  Fly   930 ERRKMQAEIDALNKQLTS---AKERAVEKE 956
            |||       |..::..|   |.|..||.|
Human   905 ERR-------ASRRRAVSEGCASEDEVEGE 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	16/87 (18%)
		DUF3694	429..523	CDD:289256	26/170 (15%)
		TBC	650..858	CDD:214540	60/213 (28%)
		Phage_Gp23	<914..991	CDD:287621	17/48 (35%)
TBC1D2	NP_001254500.1	Interaction with CADH1	1..169		20/123 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		PH_TBC1D2A	47..147	CDD:269966	15/84 (18%)
		PH	47..139	CDD:278594	14/76 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..275		5/49 (10%)
		Interaction with RAC1. /evidence=ECO:0000269\|PubMed:20116244	295..433		24/137 (18%)
		TBC	625..837	CDD:214540	59/211 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810