DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and evi5b

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_009300706.2	Gene:	evi5b / 553306	ZFINID:	ZDB-GENE-041111-244	Length:	837	Species:	Danio rerio

Alignment Length:	788	Identity:	204/788 - (25%)
Similarity:	324/788 - (41%)	Gaps:	228/788 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 KRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDE 609
            |.:...:|..||:  |..:::......:.|.|...:.:.:..:.|.|.||     |:..|.|..|
Zfish    10 KLSSTLSWVKNSV--SHTVSQMASQVATPSSLHTTVASSTASLSSPSSAS-----PTQLSPDDVE 67

  Fly   610 PLL-------------------------SGTGEVSKDCSQDTLDE--------WDPILREWDS-- 639
            .|.                         ||:..||...:...|..        |..|:.||:.
Zfish    68 LLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVR 132

  Fly   640 EKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVIQRDIHRTFPAH 704
            :|:.|.|..|||.|||...|..:||.|.|.: .:.:.::|..|:...:.||.:|:|||.||:|.|
Zfish   133 KKKEKQLKELVRKGVPHHFRAIVWQLLCNAQ-NLPIKEQYSELLKMTSPCEKLIRRDIARTYPEH 196

  Fly   705 KCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRD 769
            :.|||....||:.||.|.|||::.|.|||||||.:||...||:.||||:||||.|.||.:|.||:
Zfish   197 EFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQEYRLRE 261

  Fly   770 LYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDV 834
            |:|.....|.|.:||.|.:|::|||:||.||.|....|.||||.||||::...|||.....:.|:
Zfish   262 LFKPSMAELGLCMYQFECMIQEQLPELHVHFQAQSFHTSMYASSWFLTIFLTSFPLPVATRIFDI 326

  Fly   835 FLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERK--IK 897
            |:.:||.::|:|.:.:|.:.:::|.|||.||:|::|:..:|.:..|...  ||::.|.:.|  .|
Zfish   327 FMCEGLEIVFRVGMAILQMNQAELMQLDMEGMLQHFQKVIPHQLDSGPD--KVIQAAYQVKYNAK 389

  Fly   898 KLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSAKERAVEKE------ 956
            |:|:.|:|:...|..    |.|.|:...|...|.|.::..||.|.|:..|..:|.::.:
Zfish   390 KMKKLEKEYTTIKTK----EMEEQVEIKRLRTENRLLKQRIDTLEKESASLADRLIQGQVTRAQE 450

  Fly   957 --------------KKH-------------------------------TGIIQEYKQIIQ---RQ 973
                          |:|                               ..|:|..::::|   ::
Zfish   451 AEENYLVKRELATVKQHIEETSVQLEQAQSTIRQLQQPFAKGNPRYTEESILQLERELVQARLKE 515

  Fly   974 EQDMNTLSETLGKVMHM------------------------------VSNCQDCQQQI------- 1001
            .:....|.|...|::.|                              ::..::.:||:
Zfish   516 AESQCALKEMQDKILDMEQRNTSLPDENNVVRLQEELIGVKLREAEALTGLKELRQQVRDLEEHW 580

  Fly  1002 ------------DAGNDNAKSD-----------------------------DGKNRGQTDAMRNA 1025
                        |:...||.|:                             :.:|:..::.:|.|
Zfish   581 QRHLARTAGRWKDSPRKNAASELQDELMSVRLREAEAQAELRETRQRMLELETQNQIHSNQLRRA 645

  Fly  1026 NEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQ------------------DLNHQLS 1072
            ........|.|:..|.:.:.|..||.:.|..|.|.||||:                  :|..|:|
Zfish   646 ELEARNLQDRLHVLSNQNKMLHSELQETKRKQAEIECKNKEEVMAVRLREADNIAAMAELQQQIS 710

  Fly  1073 NTLSELQTNRNSWQPWLSKTFNS------------LQEKVTTRGGHRD-------------NGSG 1112
            ..  |:|......|..|:.|.:|            |:.::....||:.             |..|
Zfish   711 EL--EIQKEEGKVQGQLNNTDSSQYIRDLKDQIADLKHEIRCLRGHQGLPNQHTFDGIHIVNHYG 773

  Fly  1113 GPMPSFQS 1120
            |...|:||
Zfish   774 GDNESYQS 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	94/207 (45%)
		Phage_Gp23	<914..991	CDD:287621	21/160 (13%)
evi5b	XP_009300706.2	TBC	143..351	CDD:214540	94/208 (45%)
evi5b	XP_009300706.2	SMC_N	<389..718	CDD:330553	54/334 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920