Protein Alignment GAPcenA and rabgap1l

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001361730.1
• Gene: rabgap1l / 550007
• XenbaseID: XB-GENE-483580
• Length: 1056
• Species: Xenopus tropicalis
• Alignment Length: 1257
• Identity: 425/1257 - (33%)
• Similarity: 616/1257 - (49%)
• Gaps: 308/1257 - (24%)

  Fly     2 DDNLSTKSSESSITTSG--------EYEIVT--DSNVASPMEQVKQVVNQEGTQPEVGGKPPTSL 56
            ||::||.:||..:...|        |::|::  |..:...||::.:  :.|.||
 Frog    12 DDSVSTVNSEDFVLVEGSSDSEDKPEFKIMSNGDEQLEKAMEEILR--DSEKTQ----------- 63

  Fly    57 SALALSSPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSL 121
                                  |.|:  ::..:|:.|.........:.:|.|:
 Frog    64 ----------------------NSNM--LKETITEELSTFPTASHFSDTGTKN------------ 92

  Fly   122 TLPLTGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKP 186
             :|||               .:..|||.|.  ...|:..:.|                     .|
 Frog    93 -VPLT---------------LILDPKSTEL--PVQSTTVLSH---------------------PP 118

  Fly   187 EKGDTTDEEVSEIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNC 251
            |     :|.||        |..:.|||...::||::|.|..|.|..:.: .....:.:|:.:||.
 Frog   119 E-----EESVS--------FHKLCYLGCMKVSAPRNEIEALRAMASMKA-QCIAPITVTLYVPNI 169

  Fly   252 SEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLH-GDALFQCHVFRCHIPEAV 315
            .||.|.:.|..:.:.||::.|..::...||...|.|..|||||... |...||.|||.|.|.|||
 Frog   170 PEGSVRIIDQTNKSEIASFPIYKVLFCVRGRDGTSECDCFAFTERDLGTEEFQIHVFSCEIKEAV 234

  Fly   316 NQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAA 380
            :::...|..||:.....:|...:||:...:   |||         :.|:||||::|..:|.:::.
 Frog   235 SRILYSFFTAFKRSSRQVSDVKDSALPTPD---SDV---------FTFMVSLEVKEDDSKGNFSP 287

  Fly   381 VPRDRG--CFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMG 443
            ||:||.  .|||:...:|:|.:|::|. ||  :.|.:|||||:|::||:.|...||||:||.|||
 Frog   288 VPKDRDKLFFKLKQGIEKKVVVTIQQV-SN--KELLVERCFGMLLSPGRNVKNSDMHLLDMESMG 349

  Fly   444 YIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN---LTVAVDIVMRRIQ 505
                      ..||..|       |.|...|....:||:.||.|:.|..   :|||||:|:..:.
 Frog   350 ----------KSSDGKA-------YVITGIWNPNIQAFQALNEETPKDKRVYMTVAVDMVVTEVV 397

  Fly   506 EPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRT-----EESNWKVNSIDPSEEITE 565
            |||||::||.|.:...:| |..  :.|::..|..|||.||.:     .:|.::|.|:....||.|
 Frog   398 EPVRFLLETVVRVYPTNE-RFW--YFSRKAFTDTFYLKLKPSGNIGVTDSMYEVVSLQRQSEIEE 459

  Fly   566 QPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEW 630
            .|....|:|       |||        :..|:|.|.:   :.|..|.||||:|||||.:..||.|
 Frog   460 APTSPLSAS-------NLS--------SPQEEDDPEE---ESDTELWSGTGDVSKDCPEQILDCW 506

  Fly   631 DPILREWDS--EKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVI 693
            ..:|.:|.|  ..:||.|:.||:.|:|||||.::||.||......||.||||:|:.|::..::||
 Frog   507 GQLLVKWHSNLSVKPKGLSSLVKRGIPEALRAEVWQLLAGCHENQEMLDKYKMLVVKDSAQDSVI 571

  Fly   694 QRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVL 758
            :||||||||||..||...|.||::|:|:.|.|:::|..:|||||:||:||.||||||||.|||||
 Frog   572 RRDIHRTFPAHDYFKNTEGDGQESLYKMCKVYSLYDEVIGYCQGMSFLAAVLLLHMPEEQAFCVL 636

  Fly   759 VALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARF 823
            |.:||||..|:||:..||.|:.:.||||||:::|||.|:.||.|..:|.|||||||||:|:||:|
 Frog   637 VKIMYDYQFRNLYQNNFEDLHCKFYQLERLLQEQLPDLYSHFVALNLEAHMYASQWFLSLFTAKF 701

  Fly   824 PLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVM 888
            |||.|||::|:.|.:||.::|.||:.||...:.||.|.||||.||:|||.|||:.|:...||::|
 Frog   702 PLCMVFHIMDLLLSEGLSIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLM 766

  Fly   889 KQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQA--------------- 936
            :|||..|:  ||||::|:|:|..::  .:|::|..|  .|:.:|.|::|.
 Frog   767 EQACNIKVPTKKLKKFEKEYLAMRE--SQLQQEDPI--ERYKKENRRLQETSMRLEQENDDLAHE 827

  Fly   937 -----------------EIDALNKQLTSAKERAVEKE---------------------------- 956
                             :.:.|||:|...|:|.||.|
 Frog   828 LVTSKIALRNDLDQAEDKAEVLNKELLLTKQRLVEAEEEKRKQEEETAQLKEIFRKQLEKAEQEI 892

  Fly   957 KKHTGIIQEYKQIIQ----RQEQDMNTLSETLGKVMHMVSNCQDCQQQID-------AGNDNAKS 1010
            ||.|.||.|||||..    |.|:......|.|..:...|.:|..|.:...       :|:...|:
 Frog   893 KKTTAIIAEYKQICSQLSTRLEKQQTANREELEIIKAKVMSCSHCSEIFSKEGVLKTSGSCREKT 957

  Fly  1011 DDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSNTL 1075
            .||.:                  |..::..:.:||:||||||.||..|||:||.|:|.||....|
 Frog   958 GDGAD------------------DEKDSIKKHLREMELELAQTKLQLVEAKCKIQELEHQRGALL 1004

  Fly  1076 SELQTNRNSWQPWLSKTFNSLQEKVTTRGGHRDNGSGGPMPSFQSYMGQAPTTLSEASSPSGNQE 1140
            ||:|..:||   |.|||.||:  |..|                    |..|||   |.|..|:|
 Frog  1005 SEIQAAKNS---WFSKTLNSI--KTAT--------------------GTQPTT---AQSQQGSQ- 1040

  Fly  1141 YKTFAFASVGGSPKLPSKFQAT 1162
                  .|...||.||...::|
 Frog  1041 ------GSQASSPVLPVAKEST 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	43/128 (34%)
		DUF3694	429..523	CDD:289256	36/96 (38%)
		TBC	650..858	CDD:214540	116/207 (56%)
		Phage_Gp23	<914..991	CDD:287621	30/140 (21%)
rabgap1l	NP_001361730.1	PTB_Rab6GAP	123..251	CDD:269922	45/136 (33%)
		DUF3694	284..415	CDD:372133	58/150 (39%)
		TBC	528..737	CDD:214540	117/208 (56%)
		Smc	753..>1011	CDD:224117	78/279 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I2217
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I916
OMA	1	1.010	-	-		QHG49205
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm48272
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3994
SonicParanoid	1	1.000	-	-		X1488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110