Protein Alignment GAPcenA and TBC1D8B

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_060222.2
• Gene: TBC1D8B / 54885
• HGNCID: 24715
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 151/773 - (19%)
• Similarity: 267/773 - (34%)
• Gaps: 271/773 - (35%)

  Fly   399 CITVKQTPSNVLQP-LHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQ 462
            |...:..|....:. |..|:|||:   |.|   :|   |:..:|..|
Human   130 CFAKEDDPEKFREALLKFEKCFGL---PEK---EK---LVTYYSCSY------------------ 167

  Fly   463 SSSWPYTIRAEWKAQEKAFEQLNLES-----------SKTNLTVAVDIVMRRIQEPVRFVIETPV 516
                       ||.:......|.|.:           |:..|.::.|.| .::::....::...:
Human   168 -----------WKGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDEV-SKLEKTSNVILTESI 220

  Fly   517 TIQSASEMRIMDHFMSKRPMTLRFYLHLKRT-----EESNWKVNSIDPSEEITEQPGHQQSSSLL 576
            .:.|..|    :|:.|       .:||:.:|     :.:|:.:..:...|.....|.......:.
Human   221 HVCSQGE----NHYFS-------MFLHINQTYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQIT 274

  Fly   577 KMGMNNLS---------RIVRSSSIASIED---------------DCPSD-----YSSDGDE--- 609
            |.|:.|.:         |:.:..|:..:.:               .|.|:     .|.||::
Human   275 KRGLENRAHSEQFNAFFRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSV 339

  Fly   610 --PL-----LSGTGEVSK----------------------------------------------- 620
              ||     :..|.:.||
Human   340 IIPLREVLAIDKTNDSSKSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAI 404

  Fly   621 --------------------DCSQ----------------DTLD-----------EWDPILREWD 638
                                :||:                :||:           .|..:..|..
Human   405 SSESTEPSDNFEVQSLTSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECG 469

  Fly   639 ---SEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKET--KCETV---IQR 695
               |..|.|....||..|:||.||.::|...:.....|..|..|...:.:::  .|...   |:|
Human   470 RGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIER 534

  Fly   696 DIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVA 760
            |:.|:.|.|..|:  ..:|..||.:|..|||..:.::||||.::.:.:.|||:..||:||.:|||
Human   535 DLRRSLPEHPAFQ--SDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVA 597

  Fly   761 ----LMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYAS---QWFLTL 818
                ::.||..|.:..|..:...     .|.||:|.||:|.||.|    :...::|   .|||||
Human   598 VCERMLPDYFNRRIIGALVDQAV-----FEELIRDHLPQLTEHMT----DMTFFSSVSLSWFLTL 653

  Fly   819 YTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQ 883
            :.:..|:....:|:|.|..||:..:.|:.   |:|.:.:|.:|              ..|:..::
Human   654 FISVLPIESAVNVVDCFFYDGIKAILQLG---LAILDYNLDKL--------------LTCKDDAE 701

  Fly   884 ARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSA 948
            |...:.:..:....|              ...|....|...|...|:....:.:|..|.:: ::.
Human   702 AVTALNRFFDNVTNK--------------DSPLPSNVQQGSNVSDEKTSHTRVDITDLIRE-SNE 751

  Fly   949 KERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGK-VMHMVSNCQDCQ---QQID 1002
            |...:..|..|:...:....:||       ||.||..: |:.:||  ||.:   |::|
Human   752 KYGNIRYEDIHSMRCRNRLYVIQ-------TLEETTKQNVLRVVS--QDVKLSLQELD 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	13/104 (13%)
		TBC	650..858	CDD:214540	68/219 (31%)
		Phage_Gp23	<914..991	CDD:287621	16/77 (21%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419	21/144 (15%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	11/91 (12%)
		TBC	486..694	CDD:214540	69/235 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1066

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810