DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and CG42795

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001287272.1	Gene:	CG42795 / 41252	FlyBaseID:	FBgn0261928	Length:	3213	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	175/786 - (22%)
Similarity:	287/786 - (36%)	Gaps:	199/786 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 VAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDP 559
            ||.|.:.|..:....||  |.|.|..:.:.:....| |..|...:.....:.|..:.   ||:..
  Fly    91 VARDRLQRHQEVLCEFV--TAVLIVESDDAQPKMRF-SLSPPPQKAITSARLTSPTK---NSLSS 149

  Fly   560 SEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEV-SKDCS 623
            :..||....:.:|.|..|..|  |:|                :....|..|..||:|.. |...:
  Fly   150 NNTITTPGSNNRSPSSTKTTM--LTR----------------NGGGHGTSPTASGSGHAPSATAA 196

  Fly   624 QDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKET- 687
            .|  ||......:|   .....|...:..|.|...|.|:|..||         |||  |.:|..
  Fly   197 AD--DEATSDYNQW---LHAMKLVARLPGGTPPEFRRKLWLSLA---------DKY--LKSKNVD 245

  Fly   688 ------KC----------ETVIQ--RDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGY 734
                  ||          |..||  :|:||| .::.|....|...|..|.::...||.::.||||
  Fly   246 WAQQREKCFCEEWREDDEELGIQIVKDLHRT-GSNLCTGPAGSINQAKLKRILLGYARYNPEVGY 309

  Fly   735 CQGLSFIAASLL--LHMPEEDAFCVLVALM-------YDYGLRDLYKAGFEVLYLRLYQLERLIK 790
            |||.:.:.|.:|  :...||::..|::.|:       |.||.....:|...|       ...|::
  Fly   310 CQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGV-------FRELMQ 367

  Fly   791 DQLPKLHEHFTAC--GIE-------THMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQV 846
            .:||:|.:|....  .:|       |:::..|||||::....|:..|..|.|:.|::|..||.:.
  Fly   368 TRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRT 432

  Fly   847 AVTLLSICES---DLRQLD-FEGILKYFRVTL--PKKCRSSSQARKVMKQACERKIKKLKQYEEE 905
            |:.|.|:.|.   .:|..| |.|.:..:...|  .....|:....:|:|..   .|:.|:|..::
  Fly   433 ALVLWSLLEERVISVRSADEFYGKMGSYSSELLNGHLVDSNGLIERVVKLG---PIEDLRQLRDK 494

  Fly   906 FLLK---KQHKERLEKEAQIY---ENRFGEERRKMQAEIDALN-------KQLTSAKERAVEKEK 957
            .|..   .:||:.|    |:|   |:...:|.|...|.:..||       ....:.|::..:|::
  Fly   495 HLYNIAPLRHKQGL----QLYYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDR 555

  Fly   958 KHTGII---QEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQ------QIDAGNDNAKSDDG 1013
            ....|.   ::|.::.:||:|....|:..........|......|      |:..|.....::.|
  Fly   556 LALDISLLKKQYDRLRERQKQAHVILTTACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKG 620

  Fly  1014 KNRGQTDAMRNANEHPLGPLDPLNAAS-------QRIRELELELAQAKL-AQVEAECKNQDLNHQ 1070
            |..|.          |||.:.|....|       :...|.:|...:..| ...:...:.:|
  Fly   621 KRVGA----------PLGAIPPARKPSLPAVLHTKPTSEKQLRRGETLLWRDTDPSRRRRD---- 671

  Fly  1071 LSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTR-------------GGHRDNGSGGPMPSFQSYM 1122
             |.|..|::.:|.:.........:...:|:.||             .|.:::|:||...|
  Fly   672 -SLTWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKSDSSSYSEDSDGEQESGTGGGGGS----- 730

  Fly  1123 GQAPTTLSEASSPSGNQEYKTFAFASVGGSPKLPSKFQATKLRNSIDSLRNIVVPLDTGKTLAEN 1187
             ...|:|.:...|...::           |||..:|                         ||..
  Fly   731 -STDTSLCDDDDPKSTEK-----------SPKQKAK-------------------------LARK 758

  Fly  1188 LKQQLQ 1193
            ||:|.|
  Fly   759 LKEQKQ 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	9/27 (33%)
		TBC	650..858	CDD:214540	69/247 (28%)
		Phage_Gp23	<914..991	CDD:287621	17/89 (19%)
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:278964	53/182 (29%)
		DUF4682	560..684	CDD:292361	26/138 (19%)
		DBP	1112..1415	CDD:289157
		SWIRM-assoc_2	<2376..2482	CDD:293105
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740