DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and plx

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster

Alignment Length:	1428	Identity:	300/1428 - (21%)
Similarity:	515/1428 - (36%)	Gaps:	406/1428 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ASPMEQVKQVVNQEGTQPEVGGKPPTSLSALALS-----SPEAGGDRSPTLDMAHNRNLS---DM 85
            |:|...:|........|.:....|.:|....:.|     |..:|....||...|.: |||   |:
  Fly   239 ATPATNLKMSEAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQS-NLSLLADI 302

  Fly    86 QHEMTDALKDLELERGVAASGEK----------------SAQRLPSHQQKSLTLPLTGSGGGSVD 134
            ....|...:.:.:.: :..|.::                .||||...|.:.::  |:..||..::
  Fly   303 SPNHTHFFEVMYVGK-IRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMS--LSSEGGVGIE 364

  Fly   135 PEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCID-----------------ASPACVEEKQD 182
            .:   |.:.......:..|:.......||.   |..|                 |:|..:|:.::
  Fly   365 AK---PSSSLKSHDLKEEDEEEQEQHKGHD---DSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKE 423

  Fly   183 AMKPEK-----GDTTDE-EVSEIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVG 241
            ...|||     |.:..| ...|...|....:..:.|.|.|:...|..|.. |..| :.:|:.|..
  Fly   424 NKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPP-RDQG-VGTGTASAS 486

  Fly   242 LKITVSIPN-------------CSEGLVVLHDAESNT---IIATYEISSI------ILYYRGPVD 284
            ...:...||             .|:|.:..:..::.|   ::...::..|      :|.|:...|
  Fly   487 AGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKD 551

  Fly   285 TVENGCFAFTWLHGDALFQ-----C----------HVFRCHIPEAVNQVSACFQKAFQTYPPS-- 332
            ..  .|     :||.....     |          :||:|......:.:.|...:||.|....
  Fly   552 VA--SC-----VHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKK 609

  Fly   333 ------MSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEI-------RERV-AK-------N 376
                  .||. :..:...:.:.:||.|  |:....:.::...|       :|.| ||       |
  Fly   610 KQDTQIFSCE-HCPMLWYHKLCTDVEG--LSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTN 671

  Fly   377 SYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQPLH---------------IERCFGVLVAPG 426
            |..|.........|||:.:......|..|..|..:.|:               :...|..|:
  Fly   672 SPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLL--- 733

  Fly   427 KLVVQKDMHLIDMHSM-----GYIQPGGT-----GVATESDSNAQQSSSWPYTIRAEWKAQEKAF 481
            |....||...:..|::     |..:|.||     |..:.|::.....||.|            ..
  Fly   734 KRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKP------------TA 786

  Fly   482 EQLNLESSKTNLTVAVDIVMRRIQEPV----------RFVIETPVTIQSASEMRIMDHFMS--KR 534
            |||.        :..:||.::....|.          :.::.:.||.....:..:...|:|  ::
  Fly   787 EQLK--------SPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRK 843

  Fly   535 P----------------MTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNL 583
            |                ..:|..:.|.|.|..|..:.:                    :...|.|
  Fly   844 PAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA--------------------RQNENEL 888

  Fly   584 SRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILR----EWDSEKRPK 644
            .||             ..||             |....|.:..::.|:.|:.    :..::|.||
  Fly   889 KRI-------------KLDY-------------EEIVPCDKQLIERWEQIIERNSTQIGNKKDPK 927

  Fly   645 NLAPLVRLGVPEALREKIWQKLAN--------VEGRM--EMNDKYKILITKETKCETVIQRDIHR 699
            .|...:|.|||.:.|..:|..||.        |:.:.  ..|..|.:|:...|:.:..|..|:.|
  Fly   928 VLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGR 992

  Fly   700 TFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYD 764
            |||.|:.:|:..|.||.:||.:.|||::.|.|:||||||.||...||||..|.::|.:|..||:.
  Fly   993 TFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFR 1057

  Fly   765 YGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVF 829
            ..:|..|....:...|:||||.||:||.||.|:.......:...:||:.|.||:::::|||.||.
  Fly  1058 RNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVA 1122

  Fly   830 HVLDVFLLDGLPVLFQVAVTLLSICESDLRQLD-FEGILKYFRVTLPKKCRSSSQARKVMKQACE 893
            .|.|:..|:...|:|:.|:.|||:.:..|...| ||.|:.|.:..:||           |:..|.
  Fly  1123 RVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPK-----------MEHTCM 1176

  Fly   894 RKI----------KKLKQYEEEFLL-----------------KKQHKERLEKEAQIYENRFGE-- 929
            .:|          |:|.:|:.|:.:                 :|...:.||::.|..::...:
  Fly  1177 EQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLE 1241

  Fly   930 -ERRKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQEYK------QIIQRQEQDMNTL------- 980
             .|...||:|..|..|:.|. |..::...::.|.:.|:.      ..::|..|.::.|
  Fly  1242 TTRSSQQAQITTLQSQVQSL-ELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKP 1305

  Fly   981 ---SETLGKVMHMVSNC-----------------------------------QDCQQQIDAGNDN 1007
               ...:||.:.:.|:.                                   |..|.:::.|..:
  Fly  1306 IFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQS 1370

  Fly  1008 AKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLS 1072
              |:.|::...|...|     |...||  ||:::.:.:::|:  :.||.        :.::..::
  Fly  1371 --SNVGESGSPTPPSR-----PNRLLD--NASARTVMQVKLD--ELKLP--------EHVDKFVA 1416

  Fly  1073 NTLSELQTNRNSWQPWL--SKTFNSLQEKVTTRGGHRDNGSG-GPMPSFQSYMGQAPTTLSEASS 1134
            |..|.|:.:.....|..  |...||....:.:|.|:|..... .|:...||| |.|.||   |..
  Fly  1417 NIKSPLEVDSGVGTPLSPPSTASNSSGGSIFSRMGYRTTPPALSPLAQRQSY-GVAITT---APC 1477

  Fly  1135 PSGNQEY---KTFA---------------FASVGGSPKLPSKFQATKLRNSIDSLRNI-VVPL 1178
            |...:|.   .|.|               .:.|||...:  :|:.|....||..:.:: .:||
  Fly  1478 PQHMEEVAPATTMAVMPQEDVEEPQPMHPLSMVGGDVNV--RFKGTTQLKSIRPVHHMRAIPL 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	29/164 (18%)
		DUF3694	429..523	CDD:289256	20/113 (18%)
		TBC	650..858	CDD:214540	81/217 (37%)
		Phage_Gp23	<914..991	CDD:287621	18/95 (19%)
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	53/317 (17%)
		DUF3350	835..880	CDD:288663	8/44 (18%)
		TBC	933..1152	CDD:214540	81/218 (37%)
		RILP-like	<1176..1267	CDD:304877	17/91 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456546
Domainoid	1	1.000	109	1.000	Domainoid score	I1618
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940