DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006538109.1	Gene:	Tbc1d2 / 381605	MGIID:	2652885	Length:	923	Species:	Mus musculus

Alignment Length:	309	Identity:	90/309 - (29%)
Similarity:	144/309 - (46%)	Gaps:	27/309 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 DEWDPILREWDSEKRPK-NLAPLVRLGVPEALREKIWQKLANVEGR-MEMNDKYKILITKETKCE 690
            |.|..:     :|..|. .|..|:|.|||...|.::|:.|.:...| ::....|:.|:.:...||
Mouse   599 DRWATL-----TELTPSAELKQLLRAGVPREHRPRVWRWLVHRRVRHLQAPGCYQELLARGRACE 658

  Fly   691 ----TVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAA-SLLLHMP 750
                ..|:.|::||||.:|.|.....|..|.|.:|..|::..:..:||||||:.:|| :||:...
Mouse   659 HPAARQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLED 723

  Fly   751 EEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWF 815
            ||.||..|||::......:.|........:....|:.|:.::||:|..|.....::..:....||
Mouse   724 EESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQHRVDLSLITFNWF 788

  Fly   816 LTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQL-DFEGILKYFRVTLPKKCR 879
            |.::........:..|.|.||.:|..|:|:.|:.:....|..:.|| |...|.:|.|......|.
Mouse   789 LVVFADSLISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLRFFTKTICD 853

  Fly   880 SSSQARKVMKQACER----KIKKLKQYEEEFLLKKQHKERLEKEAQIYE 924
            |    ||:|..|...    .:|:|:|      |:..|:||||.|.:..|
Mouse   854 S----RKLMSIAFNDMNPFPMKQLRQ------LRAAHRERLEAELRELE 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	61/213 (29%)
		Phage_Gp23	<914..991	CDD:287621	6/11 (55%)
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966
		PRK14951	<192..404	CDD:237865
		COG4913	<300..>565	CDD:227250
		TBC	620..832	CDD:214540	60/211 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810