DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Tbc1d14

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001106836.1	Gene:	Tbc1d14 / 360956	RGDID:	1309993	Length:	714	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	152/705 - (21%)
Similarity:	250/705 - (35%)	Gaps:	189/705 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 CHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCS----------------------------LNSA 340
            |.|  .|:....::.....::|||:..|..||:                            |.|.
  Rat   102 CSV--VHVKRKQSESEIIPERAFQSACPLPSCTPSAPTGSEREQAVRKSSTFPRTGYDSVKLYSP 164

  Fly   341 VDMANSVTSDVSGNPLNTAGYEFIVSLEIRER------VAKNSYAAVPRDR-----------GCF 388
            ...|.|.:.|||...:::.|.|...:|.:...      |..||.|.|..:.           ...
  Rat   165 TSKALSRSDDVSVCSVSSLGTELSTTLSVSNEDILDLMVTSNSSAIVTLENDDDPQFTDVTLSSI 229

  Fly   389 KLRANTDKEVCI--TVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTG 451
            |..::..::.|:  |.:.....:|||      |........|..:::..|.....:|:...|...
  Rat   230 KETSDLHQQDCVAETEEGRKLRLLQP------FSHFFTRNLLARKQNARLDRQRDLGWKLFGKVP 288

  Fly   452 VATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQEPVRFVIETPV 516
            :.    ..||:.|.     :.:.:.::||.......|.|.|:...:|.      ||    :.|..
  Rat   289 LR----ETAQKDSK-----KTQKEYEDKAGRPSRPPSPKQNVRKNLDF------EP----LSTTA 334

  Fly   517 TIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQ--SSSLLKMG 579
            .|            :..||..|                    |::...|...|:|  ...:::..
  Rat   335 LI------------LEDRPANL--------------------PAKPAEEAQKHRQQYEEMVVQAK 367

  Fly   580 MNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPK 644
            ...|....|...  .:|:.|..:.|          .|......:.:.|..|:.:   |.|:|
  Rat   368 KRELKEAQRRKK--QLEERCKVEES----------IGNAVLTWNNEILPNWETM---WCSKK--- 414

  Fly   645 NLAPLVRLGVPEALREKIWQ-KLANVEGRMEMN--------------DKYKILITKETKCET--- 691
             :..|...|:|.::|.|:|. .:.|     |:|              ::::.|.|..::.|.
  Rat   415 -VRDLWWQGIPPSVRGKVWSLAIGN-----ELNITHELFDICLARAKERWRSLSTGGSEVENEDA 473

  Fly   692 ------------VIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAAS 744
                        :|:.||.|||| :.|..:.||...|.|..:..||..:..:|||.||:|||||.
  Rat   474 GFSAADREASLELIKLDISRTFP-NLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAV 537

  Fly   745 LLLHMPEEDAF----------CVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEH 799
            |:|::...|||          |.:.....|:||...|.|.|||.:          ::.||||..|
  Rat   538 LILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFF----------EENLPKLFAH 592

  Fly   800 FTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFE 864
            |....:...:|...|..|||:...||.....:.|||..||...||:.|:.:|.:.|..|.::||.
  Rat   593 FKKNNLTADIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTRMDFI 657

  Fly   865 GILKYFRVTLPKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKE 919
            ...: |...||:...:......:.....:.:.||..|     :|....|:..|.|
  Rat   658 HSAQ-FLTRLPEDLPADDVFAAISTVQMQSRNKKWAQ-----VLSALQKDSREME 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	6/27 (22%)
		DUF3694	429..523	CDD:289256	16/93 (17%)
		TBC	650..858	CDD:214540	72/247 (29%)
		Phage_Gp23	<914..991	CDD:287621	2/6 (33%)
Tbc1d14	NP_001106836.1	DUF4207	147..384	CDD:290615	49/295 (17%)
Tbc1d14	NP_001106836.1	TBC	419..651	CDD:214540	72/247 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810