Protein Alignment GAPcenA and Tbc1d1

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001414246.1
• Gene: Tbc1d1 / 360937
• RGDID: 1304562
• Length: 1257
• Species: Rattus norvegicus
• Alignment Length: 1027
• Identity: 235/1027 - (22%)
• Similarity: 386/1027 - (37%)
• Gaps: 274/1027 - (26%)

  Fly   128 SGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGDTT 192
            ||||...  ..|.|.:|...:|..:|:...:.:...:|         |.|:  |.|..|
  Rat   332 SGGGGAG--FHFVCYVFQCTNEALVDEIMMTLKQAFTV---------AAVQ--QTAKAP------ 377

  Fly   193 DEEVSEIDQGCTIFSGVTYL--GAANINAPKSETEVYRIMGELNSGSKSVGL------------- 242
                :::.:||.: .|:..|  ....:|:.|::.|:.:.:..|.:..:::..
  Rat   378 ----AQLCEGCPL-QGLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQAMIFEEVQKLRPRNEQR 437

  Fly   243 --KITVSIPNCSEGLVVLHDAE----SNT-------IIATYEISSII--LYYRGPVDTVENGCFA 292
              ::.:|...|      |::.:    |:|       .:|...|.|.:  ...|..:|:::|..
  Rat   438 ENELIISFLRC------LYEEKQKEHSHTGEPKQTLQVAAENIGSELPPSASRFRLDSLKNRA-- 494

  Fly   293 FTWLHGDALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTS------DV 351
                           :..:.|::..:.:...||......|.|..|:|:.....|.||      |.
  Rat   495 ---------------KRSLTESLESILSRGNKARGLQDHSASVDLDSSTSSTLSNTSKELSMGDK 544

  Fly   352 SGNPLNTAGYEFI-----VSLEIRERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQ 411
            ...|::.:.::.:     :|.:....:|:.|....|:.  .|:.||||.....:.....|    :
  Rat   545 EALPISESSFKLLGSSDDLSSDSESHIAEESALLSPQQ--AFRRRANTLSHFPVECPAPP----E 603

  Fly   412 PLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSN---------------AQ 461
            |..        .:||  |.|:  .|:..||          |:||:...               .|
  Rat   604 PAQ--------TSPG--VSQR--KLMRYHS----------VSTETPHERNVDHLPGGESRCCPGQ 646

  Fly   462 QSSSWPYTIRAEWKAQE-KAFEQLNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMR 525
            .|...|...|....|.. ..|:.|...||......||                 |.::...:.:|
  Rat   647 PSDPPPLPPRLNPSASSPNFFKYLKHNSSGEQSGNAV-----------------PKSVSYRNALR 694

  Fly   526 IMDHFMSKRPMTLRFYLHLKRTEESNWKVNSID---PSEEITEQPGHQQSSSLLKMGMNNLSRIV 587
            ...|..|..|..|:|...:......::|..:.|   .:..:.:..|....:...........|:.
  Rat   695 KKLHSSSSVPNFLKFLAPVDENNTCDFKNTNRDFESKANHLGDTDGTPVKARRHSWRQQIFLRVA 759

  Fly   588 RSSSIASIEDDCPS---DYSSDGDEPLLSGTGEVSKD---------------------------- 621
            ......    |.||   |||..|:.|..|....|.:|
  Rat   760 TPQKAC----DSPSRYEDYSELGELPPRSPLEPVCEDGPFGPVQEEKKKTSRELRELWKKAILQQ 820

  Fly   622 ----------------------------------CSQDTLDEWDPILR-------EWDSEKRPKN 645
                                              |.::....|:.:|.       ::|.||
  Rat   821 ILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEK---- 881

  Fly   646 LAPLVRLGVPEALREKIWQKLAN-------VEGRMEMND-KYKILITKETKCETVIQRDIHRTFP 702
            :...|..|||...|.:||:.||.       ...:.:..| .||.|:.|.|..:..|..|:.||||
  Rat   882 VHSAVGQGVPRHHRGEIWKFLAEQFHLKHPFPSKQQPKDVPYKELLKKLTSQQHAILIDLGRTFP 946

  Fly   703 AHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGL 767
            .|..|....|:||.:|:.:.|||::.|.||||||||||:|..|||||.||:||.:|..||:|.||
  Rat   947 THPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGL 1011

  Fly   768 RDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVL 832
            |..|:....:|.:::|||.||:.|....|:.|.....|...:||:.||||::.::|||.||..|.
  Rat  1012 RKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEYEIGPSLYAAPWFLTVFASQFPLGFVARVF 1076

  Fly   833 DVFLLDGLPVLFQVAVTLL-SICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKI 896
            |:..|.|..|:|:||::|| |.....|:..:.|.|:.:.:.|||.  ....|..|.:.|..|..|
  Rat  1077 DMIFLQGSEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPN--LGLVQMEKTISQVFEMDI 1139

  Fly   897 -KKLKQYEEEF------------LLKKQHKERLEK-EAQIYENRFG--EERRKMQAEIDAL---- 941
             |:|:.||.|:            |...|..::||| .:.:.:....  |:.:...|.|.:|
  Rat  1140 AKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANARIQSLEVTV 1204

  Fly   942 NKQLTS---AKERAVEKEKKHTGIIQEYKQIIQRQ-------EQDMNTLSET 983
            .|.|||   .|:..:..|.:.:.::|..:: ::||       |.|...|..|
  Rat  1205 EKLLTSESKLKQAVLTLEMERSALLQMVEE-LRRQMAQPSTAEPDCTRLEPT 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	20/157 (13%)
		DUF3694	377..523	CDD:463599	31/161 (19%)
		TBC	650..858	CDD:214540	91/216 (42%)
		SMC_prok_B	<876..>1087	CDD:274008	32/138 (23%)
		TPH	<883..>977	CDD:464007	29/123 (24%)
Tbc1d1	NP_001414246.1	None