DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and TBC1D26

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001375394.1	Gene:	TBC1D26 / 353149	HGNCID:	28745	Length:	468	Species:	Homo sapiens

Alignment Length:	489	Identity:	112/489 - (22%)
Similarity:	176/489 - (35%)	Gaps:	124/489 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 DEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMN-DKYKILITKETKCET 691
            ::|..:|.:|...:..|.|:..|...:|.|:|.:.|..|.:::.....| .|||::..|..:...
Human    76 NKWQKMLADWTKYRSTKKLSQRVYKVIPLAVRGRAWSLLLDIDRIKSQNPGKYKVMKEKGKRSSR 140

  Fly   692 V---IQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEED 753
            :   ||.|:..|...|..|.:..|..|..|..:..||:.::.||||.:.||.|.|.|||.:||||
Human   141 IIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEED 205

  Fly   754 AFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACG--IETHMYASQWFL 816
            ||..|..|     |...|......|...|...|:::....||:..|....|  ||..|      |
Human   206 AFWALTQL-----LAVFYSPNTAWLERLLSHQEQVLHKSFPKIMRHLGKEGLCIEGSM------L 259

  Fly   817 TLYTARFPLCFV--------FHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVT 873
            |    |...||:        ..:.|||:|:|..||..:......|....|.:|.:..:.::
Human   260 T----RLLRCFLDGKSFGLTLRLWDVFILEGARVLTAMVHASFKIHRKHLMKLSWSTVWEF---- 316

  Fly   874 LPKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEI 938
                                                   :|||.:...:.:|..   .|.:|..:
Human   317 ---------------------------------------QERLSQSWALEDNAV---LRNLQTSM 339

  Fly   939 DALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDA 1003
                |:||          |||..:......:   |.....|::..|               |..|
Human   340 ----KELT----------KKHWDLPPPGSLL---QNAHCYTIAWGL---------------QSKA 372

  Fly  1004 GNDNAKSDDGKNRGQTDAMRNANEHPLGPLDP-LNAASQRIRELELELAQAKLAQVEAEC----- 1062
            |.|:..|     |...|...:.::..|  |:| .:..:|:.|......|.....:::.||
Human   373 GKDSCTS-----RASGDFHAHPSQKAL--LNPGCHLPAQKRRNEGQPAADQSQKEMKCECMAFLT 430

  Fly  1063 KNQDLNHQLSNTLSELQTNRN----SWQPWLSKT 1092
            ..|:..|:....|..|...|:    :..|||..|
Human   431 PRQNFGHKARLQLWPLTWTRDAPMQAGVPWLLLT 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	66/221 (30%)
		Phage_Gp23	<914..991	CDD:287621	15/76 (20%)
TBC1D26	NP_001375394.1	TBC	98..306	CDD:214540	66/222 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810