Protein Alignment GAPcenA and TBC1D26

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001375394.1
• Gene: TBC1D26 / 353149
• HGNCID: 28745
• Length: 468
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 112/489 - (22%)
• Similarity: 176/489 - (35%)
• Gaps: 124/489 - (25%)

  Fly   628 DEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMN-DKYKILITKETKCET 691
            ::|..:|.:|...:..|.|:..|...:|.|:|.:.|..|.:::.....| .|||::..|..:...
Human    76 NKWQKMLADWTKYRSTKKLSQRVYKVIPLAVRGRAWSLLLDIDRIKSQNPGKYKVMKEKGKRSSR 140

  Fly   692 V---IQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEED 753
            :   ||.|:..|...|..|.:..|..|..|..:..||:.::.||||.:.||.|.|.|||.:||||
Human   141 IIHCIQLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEED 205

  Fly   754 AFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACG--IETHMYASQWFL 816
            ||..|..|     |...|......|...|...|:::....||:..|....|  ||..|      |
Human   206 AFWALTQL-----LAVFYSPNTAWLERLLSHQEQVLHKSFPKIMRHLGKEGLCIEGSM------L 259

  Fly   817 TLYTARFPLCFV--------FHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVT 873
            |    |...||:        ..:.|||:|:|..||..:......|....|.:|.:..:.::
Human   260 T----RLLRCFLDGKSFGLTLRLWDVFILEGARVLTAMVHASFKIHRKHLMKLSWSTVWEF---- 316

  Fly   874 LPKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEI 938
                                                   :|||.:...:.:|..   .|.:|..:
Human   317 ---------------------------------------QERLSQSWALEDNAV---LRNLQTSM 339

  Fly   939 DALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDA 1003
                |:||          |||..:......:   |.....|::..|               |..|
Human   340 ----KELT----------KKHWDLPPPGSLL---QNAHCYTIAWGL---------------QSKA 372

  Fly  1004 GNDNAKSDDGKNRGQTDAMRNANEHPLGPLDP-LNAASQRIRELELELAQAKLAQVEAEC----- 1062
            |.|:..|     |...|...:.::..|  |:| .:..:|:.|......|.....:::.||
Human   373 GKDSCTS-----RASGDFHAHPSQKAL--LNPGCHLPAQKRRNEGQPAADQSQKEMKCECMAFLT 430

  Fly  1063 KNQDLNHQLSNTLSELQTNRN----SWQPWLSKT 1092
            ..|:..|:....|..|...|:    :..|||..|
Human   431 PRQNFGHKARLQLWPLTWTRDAPMQAGVPWLLLT 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	377..523	CDD:463599
		TBC	650..858	CDD:214540	66/221 (30%)
		SMC_prok_B	<876..>1087	CDD:274008	35/220 (16%)
		TPH	<883..>977	CDD:464007	13/93 (14%)
TBC1D26	NP_001375394.1	TBC	98..306	CDD:214540	66/222 (30%)