Protein Alignment GAPcenA and Tbc1d15-17

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Alignment Length: 711
• Identity: 133/711 - (18%)
• Similarity: 238/711 - (33%)
• Gaps: 243/711 - (34%)

  Fly   435 HLIDMHSMGYI---------------------QPGGTGVATESDSNAQQSSSWPYTIRAEWKAQE 478
            |:.|:::.|.:                     ||..: :....||  |....|....|...:.:.
  Fly    57 HIADLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPNDS-IMIADDS--QDQGDWALVDRISGRTRT 118

  Fly   479 ----KAFEQLNLESS----------KTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDH 529
                :||....:|.|          :..|.....:.:|...:.:||:.:....:.|....:..:.
  Fly   119 TSECRAFNTRPIEPSGGATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNA 183

  Fly   530 FMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSS---- 590
            .:..|.|..:..:....|..|..:|.:|    ..||....:::.:.|.:|....|::.|.|
  Fly   184 DLFVRSMRDQHLIENAETSRSGGEVYAI----LTTENQKLKKTFAELDIGQIKASQLPRESWLPN 244

  Fly   591 SIASIEDDCPSDY------SSDGDEP--LLSGTGEVSKD--------------CSQ--------- 624
            .:|.|..:.| ||      .|....|  |:||..:.|.|              ||.
  Fly   245 KLAGILGNIP-DYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSA 308

  Fly   625 ---------DTLDEWD-----------------PILR-EW----------DSEKRPKNLAPLVRL 652
                     :||:..|                 |:.. :|          ....|.|.|  :.|.
  Fly   309 EKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKEL--IFRG 371

  Fly   653 GVPEALREKIWQKLAN-----------VEGRMEMNDKYK------ILIT----------KETKCE 690
            ||.::||.::|:.|.|           :|.|.:.:.:|.      :.:|          :|.||:
  Fly   372 GVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQ 436

  Fly   691 TVIQRDIHRTFPAHKCFKEIGGSGQD-----ALFKVSKAYAVHDSEVGYCQGLSFIAASLL-LHM 749
              |::|:.||..:.:.|     :|:|     .|..:...|.:::.::||.||:|.:.|.:| :.:
  Fly   437 --IEKDVKRTDRSLQFF-----AGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQV 494

  Fly   750 PEEDAFCVLVALMYDYGLRDLYKAGFEV----LYLRLYQLERLIKDQLPKLHEHFTACGIETHMY 810
            .|.|.|...|      |..:|....|::    :..:..|:.|||:.....|..:..:...:...:
  Fly   495 NEVDTFWCFV------GFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYF 553

  Fly   811 ASQWFLTLYT----------------ARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLR 859
            ..:|.|..|.                .|.| |..||           :||.||     |.:.:.|
  Fly   554 CFRWLLVWYKRELNSEDVLKLWECLWTRLP-CPNFH-----------LLFSVA-----ILDQETR 601

  Fly   860 -----QLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKE 919
                 |.:|..|||:                 |.:.:....::|..|..|...|:.:..|.|..:
  Fly   602 VIIDSQYEFTEILKH-----------------VNELSGNIDVQKTLQVAEGIYLQLKGSETLPND 649

  Fly   920 ---------------AQIYENRFGEERRKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQE 965
                           .:|......||........|.|.|:||.      |::.:...:::|
  Fly   650 IRSIIGEPLLPAAAGEEIDGGMVDEEPTYSDDGFDELVKELTP------EEKVRQQALLEE 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	377..523	CDD:463599	19/122 (16%)
		TBC	650..858	CDD:214540	56/260 (22%)
		SMC_prok_B	<876..>1087	CDD:274008	17/105 (16%)
		TPH	<883..>977	CDD:464007	17/98 (17%)
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	56/258 (22%)