Protein Alignment GAPcenA and tbc1d4

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: XP_002663441.2
• Gene: tbc1d4 / 321065
• ZFINID: ZDB-GENE-030131-9881
• Length: 1246
• Species: Danio rerio
• Alignment Length: 1179
• Identity: 271/1179 - (22%)
• Similarity: 449/1179 - (38%)
• Gaps: 365/1179 - (30%)

  Fly    78 HNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTGSGGGSVDPEMRFPCT 142
            |.:..|.:..:..|..:..|:||        ...||.:.|:.|...|:....|  .||.....|.
Zfish   182 HKKAPSTLIDDCIDKFRQHEIER--------KRLRLLNGQRNSTEAPVEFIMG--EDPLSSSLCE 236

  Fly   143 LFTPKSEETLDDASSSNRVGHSVFYDCIDAS---------PACVEEKQDAMKPEKGDTTDEEVSE 198
            :..|:||.:|.:...| .||:... |..::|         |.|:.|          |:...|..|
Zfish   237 VDEPESEPSLTEEELS-EVGNGKL-DLANSSSTGSLRGAFPECILE----------DSGFGEQQE 289

  Fly   199 IDQGCTIFSG---------------VTYLGAAN----INAPKSETEVYRI----MGELNSGSKSV 240
            |...|...:|               ..:..|.|    .:|.|:.|.::::    :..::..:|||
Zfish   290 IRTRCNSLAGGLQKRPREAGKGTTRRRHASAPNNVQPSDADKNRTMLFQVGRFEVNLISPDTKSV 354

  Fly   241 GL-KITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDALFQC 304
            .| |....|.:||:|           :..|.....|..      |.||:         |.|.:.|
Zfish   355 VLEKNFKDISSCSQG-----------VKQTDHFGFICR------DVVES---------GPAQYVC 393

  Fly   305 HVFRCHIPEAVNQVSACFQKAFQT--------------------------------YPPSMSCSL 337
            :||:|.....|::|....::||.|                                |||....::
Zfish   394 YVFQCASESLVDEVMLTLKQAFTTAAALQSSQNQIKLCEACPMHDLHKLCERIEGLYPPRAKLAI 458

  Fly   338 ---------NSAVDM---------------------------------------------ANSVT 348
                     |..|::                                             .:|||
Zfish   459 QKYLSQLSDNEQVNIFEQVQKMKPASDHEENELVILHLRQLCETKQKSHVHIGEVTQNVSGSSVT 523

  Fly   349 SDVSG---NPL----NTAGYEFIVSLE---------IRERVAK-------------------NSY 378
            ||.|.   |.|    |.|......|||         :|.|:..                   .||
Zfish   524 SDNSSAGRNKLDVFKNKARSSLTSSLENIFSRGASRMRMRLGSMGSFDRQGDSPGDSPPGTPPSY 588

  Fly   379 AAVPRDRGCFKLRANT------DKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLI 437
            .....|...|:.||:|      .|::..|...:.:| ..||..::.    :||         .|:
Zfish   589 LEEDPDAPQFRRRAHTFSHPPIKKKISFTDVSSQAN-KAPLRRQQS----LAP---------ELL 639

  Fly   438 DMHSMGYIQPGGTGVATESDSNAQQSSSW--PYTIRAEWKAQEKAFEQL---------NLESSKT 491
            ...::|:.:   ....:||:|....|||:  |..:::.::....:...|         |.|..|.
Zfish   640 QSSTVGFSR---VRSVSESESYFGLSSSFHTPTFLKSFYQGSLGSLASLSDSGSLKSGNGEGRKR 701

  Fly   492 NL----TVAVDIV--MRRI--QEPVRFVIETPVTIQSASEMRIMDHFMSKR--PMTLRFYLHLKR 546
            :|    |.::.:|  .||:  ::.:...:.:|:...|.| |:.:||...:.  |::.|     ..
Zfish   702 SLSGCSTDSLTLVPPPRRVSWRQKIFLRVASPMNKPSDS-MQNVDHMDGRELLPLSPR-----AL 760

  Fly   547 TEESNWKVNSIDPSEEITEQ---PG----------HQQSSSLLKMGMNNLSRIVRSSSIASIEDD 598
            |::...:.....|.:....|   |.          ||| ..|::|...| .|:..|.....|. .
Zfish   761 TQDQGDQTGPQSPEQSSAGQKRSPADYRGLWKKAIHQQ-ILLIRMEKEN-QRLEASRDELHIR-K 822

  Fly   599 CPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILR-------EWDSEKRPKNLAPLVRLGVPE 656
            ...||.            ||. .||::....||..|.       :|:.|:    :...|..|||:
Zfish   823 MKLDYQ------------EVC-SCSKELQALWDRKLSSPCRTKVQWNKEE----IHSAVCQGVPK 870

  Fly   657 ALREKIWQKLANVEGRMEM---------NDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGG 712
            :.|.::|..|:. :.|:..         ...::.|:.:.|..:..|..|:.||||.|:.|....|
Zfish   871 SRRGEVWLLLSQ-QHRLRQRLPHRQQPPETPFQDLLKQLTAQQHAILVDLGRTFPTHQYFSAQLG 934

  Fly   713 SGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEV 777
            :||.:|:.:.|||::.|:|||||||:||:|..|||||.||.:|..|..||||.|:|..|:.....
Zfish   935 AGQLSLYNLLKAYSLLDTEVGYCQGISFVAGLLLLHMSEEQSFDTLKFLMYDLGIRRQYRPDMIS 999

  Fly   778 LYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPV 842
            |.:::|||.||:.|....|:.|.....|...:||:.|||||:.::|||.||..:.|:..:.|..|
Zfish  1000 LQIQMYQLSRLLHDYHRNLYSHLDEHEICPSLYAAPWFLTLFASQFPLGFVARIFDLLFVQGTEV 1064

  Fly   843 LFQVAVTLLSICESDLRQLD-FEGILKYFRVTLPKKCRSSSQARKVMKQACERKI-KKLKQYEEE 905
            :|:||:.|||..|.::.:.| ||.|:.|.:.|:|  ..:.||..:::.:|.|..| |:|:.||.|
Zfish  1065 IFKVALCLLSSHEGEILECDSFESIVDYLKSTIP--TLTHSQMEEIITKAIEMDISKQLQAYEVE 1127

  Fly   906 F----------------------------LLKKQHKERLEKEAQIYENRFGEERRKMQAEIDALN 942
            :                            .|:||:.:.|||        ....|.|:|.
Zfish  1128 YHVLQDELSDAPPLSEDSDRLDKLEKANTQLRKQNMDLLEK--------LQAARLKIQT------ 1178

  Fly   943 KQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQID----- 1002
              |.|:.|..:.:|.|       .|.:|:..||:..:..:|:.::.:.:.:  |...:::
Zfish  1179 --LESSVESFLSRESK-------MKHLIRSLEQEKASYQKTIERMRNSLPS--DTTAEVEMTQLK 1232

  Fly  1003 -AGNDNAKS 1010
             :.|..||:
Zfish  1233 SSTNGKAKA 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	33/183 (18%)
		DUF3694	377..523	CDD:463599	34/170 (20%)
		TBC	650..858	CDD:214540	84/216 (39%)
		SMC_prok_B	<876..>1087	CDD:274008	33/170 (19%)
		TPH	<883..>977	CDD:464007	27/122 (22%)
tbc1d4	XP_002663441.2	PTB	16..159	CDD:214675
		PTB_TBC1D1_like	161..415	CDD:269967	60/280 (21%)
		DUF3350	751..812	CDD:463365	13/67 (19%)
		TBC	866..1081	CDD:214540	83/215 (39%)
		HEC1	<1085..1241	CDD:444066	38/182 (21%)