DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Evi5

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster

Alignment Length:	697	Identity:	198/697 - (28%)
Similarity:	317/697 - (45%)	Gaps:	121/697 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   567 PGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYS-------SDGDEPLLSGTGEVSKDCSQ 624
            ||.:   :|....|:.|:::..::.:  ||.|..|..|       .:.|...:|.|...:....:
  Fly    26 PGEE---NLPTSEMDLLAKLEAANKL--IESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEE 85

  Fly   625 DTLDEWDPILREWDSEKRPKN--LAPLVRLGVPEALREKIWQKLANVEGRMEMNDK--YKILITK 685
            |....|..||.:|:...:.||  ::.|||.|:|...|..:||:|:....    .||  |...|..
  Fly    86 DIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASD----GDKKQYAEYIKA 146

  Fly   686 ETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMP 750
            .:.||.||:|||.||:|..:.|||..|.||:|||.|.|||::||.|||||||..||...||:.||
  Fly   147 TSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMP 211

  Fly   751 EEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWF 815
            ||:||.|||.:|..:.:|.::|.....|.|.:||||.|:::|:|.:|.||...|.:|.||||.||
  Fly   212 EEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWF 276

  Fly   816 LTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRS 880
            |||||....:.....::||||.:|:..:|:||:.||...:..|..||.|.:||:|:..||.:..:
  Fly   277 LTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAMLKFFQKELPGRVEA 341

  Fly   881 SSQARKVMKQACERKIKKLKQYEEEF--LLKKQHKERLEKEAQIYENRFGEERRK-MQAEIDALN 942
            ..:....:..:.:...|::|:.|:|:  |.||:.:|..|......||...::|.: ::||...|.
  Fly   342 DVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELA 406

  Fly   943 KQLTSAK-ERAVEKEKKH---TGIIQEYKQIIQRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDA 1003
            .:|...: .||.|:|..:   |.::|..:..::...|..|...|..|..:.:    |:....||:
  Fly   407 DRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLSLRL----QENNVSIDS 467

  Fly  1004 GNDNAKSDDG--------KNRGQ-------------------TDAMRNANEHPLGPLDPLNAASQ 1041
            .|....|.|.        |.|.:                   .|.:||..    ..::.|....:
  Fly   468 NNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLK----AKVEELEEDKK 528

  Fly  1042 RIRE---------LELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQ 1097
            .:||         |:.||..:||.:.||....:||..::....|:       ||..|::...|..
  Fly   529 TLRETTPDNSVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQ-------WQRQLAENQRSES 586

  Fly  1098 EKVTTRGGHRDNGSGGPMPSFQSYMGQAPTTLSEASSPSGNQEYKTFAFASVGGSPKLPSKFQAT 1162
            |:.|.              :..|...:..|...::|..|.:.:             ||..:...|
  Fly   587 ERTTN--------------AVDSTPKKLLTNFFDSSKSSEHTQ-------------KLEEELMTT 624

  Fly  1163 KLR-----NSIDSLRNIVVPLDTGKTLAEN-----------LKQQLQ 1193
            ::|     ..:..||..|:.|:|...::.|           ||::|:
  Fly   625 RIREMETLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKEELE 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	95/209 (45%)
		Phage_Gp23	<914..991	CDD:287621	19/81 (23%)
Evi5	NP_727526.2	TBC	113..320	CDD:214540	95/210 (45%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456592
Domainoid	1	1.000	109	1.000	Domainoid score	I1618
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		mtm1084
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.950