Protein Alignment GAPcenA and Tbc1d2

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: XP_006238118.1
• Gene: Tbc1d2 / 313234
• RGDID: 1306860
• Length: 924
• Species: Rattus norvegicus
• Alignment Length: 1007
• Identity: 195/1007 - (19%)
• Similarity: 351/1007 - (34%)
• Gaps: 268/1007 - (26%)

  Fly     1 MDDNLSTKSSESSITTSGEYEIVTDSNVASPMEQVKQVV-----NQEGTQPEVGGKPPTSLSALA 60
            :|.:.:|...::.....|.:||.|.|.|.:.....:||:     ..:..:.|....||    ||.
  Rat    90 IDLSSATFDCKADAEEEGTFEIKTPSRVITLKAATRQVMLYWLQQLQMKRWEFHNSPP----ALP 150

  Fly    61 LSSPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGV--AASGEKSAQRLPSHQQKSLTL 123
            .:...|..:..|||.:    .|...:.|:.:.|..::...|:  .|:..:....:||..| :::|
  Rat   151 ATPAAALTENGPTLHL----KLEQEEAELEEFLCPVKTPPGLVGTAAALQPVPAMPSALQ-NISL 210

  Fly   124 PLTGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEK 188
            ...|:         ....|::..:..:      .:....|         .|. |||...:.:|::
  Rat   211 KHLGT---------EIQNTMYNIRGNK------QAQATAH---------GPP-VEESSQSAEPQR 250

  Fly   189 GD---TTDEEVSEID---------QGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVG 241
            |:   .:|..:.|.:         :.|        :.:..:..||.::..:....:..:.|::
  Rat   251 GEQPLISDPSIPEKEPEDPPKSAPRSC--------VPSGPMQKPKRQSNTFPFFSDGLARSRT-- 305

  Fly   242 LKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDALFQCHV 306
                     ..|.:|.|   |...::.|.|:.|
  Rat   306 ---------AQEKVVAL---EQQVLMLTKELKS-------------------------------- 326

  Fly   307 FRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRE 371
                            ||       .:...|:.|::.|.                        :|
  Rat   327 ----------------QK-------ELVIILHKALEAAQ------------------------QE 344

  Fly   372 RVAKNSYAAVPRDRGCFKL----------------RANTDKEVCITVKQTPSNVLQPL--HIERC 418
            :.|.::|.|...||...:|                ....|:|..:.........:|.|  |::..
  Rat   345 KRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALEQDRERLVHEAGLREQQVQALQQHVQLL 409

  Fly   419 FGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAE-WKAQEKAFE 482
            .....|..:::.:....|.:  .:...||..   ||..|..:||.       |.| .|...:|:.
  Rat   410 MDKNQAKQQVICKLSQKLTE--DLAQPQPAD---ATNGDFLSQQE-------RLEHLKDDMEAYR 462

  Fly   483 QLN--LESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQS---------ASEMRIMDHFMSKRPM 536
            ..|  |.|....:|.    :.|::.|..:.::.....:|:         .:.:|.:.......|.
  Rat   463 TQNRFLNSEIHQVTK----IWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAAGAEPG 523

  Fly   537 TLRFYLHLKRTEESNWKVN------SIDPSEEITEQ-----PGHQQSSSLLKMGMNNLSRI---- 586
            .....|.....|...|:..      .:.|..|..:.     |.::...  ||:    |::|
  Rat   524 DFPELLQQLVQEALQWEAGEASDSVGLSPVSEYDDYGFLTVPDYEVED--LKL----LAKIQALE 582

  Fly   587 VRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPK-NLAPLV 650
            |||..:.::|         ..:.||               .|.|..:     :|..|. .|..|:
  Rat   583 VRSHHLLALE---------AVERPL---------------RDRWATL-----TELMPSAELKQLL 618

  Fly   651 RLGVPEALREKIWQKLAN--VEGRMEMNDKYKILITKETKCE----TVIQRDIHRTFPAHKCFKE 709
            |.|||...|.::|:.|.:  |: .:..:..|:.|:.:...||    ..|:.|::||||.:|.|..
  Rat   619 RAGVPREHRPRVWRWLVHRRVQ-HLHSSGCYQELLARGRACEHPAARQIELDLNRTFPTNKHFTC 682

  Fly   710 IGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAA-SLLLHMPEEDAFCVLVALMYDYGLRDLYKA 773
            ...|..|.|.:|..|::..:..:||||||:.:|| :||:...||.||..|||::......:.|..
  Rat   683 PTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPAEYYSK 747

  Fly   774 GFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLD 838
            ......:....|:.|:.::||:|..|.....::..:....|||.::........:..|.|.||.:
  Rat   748 TLTASQVDQRVLQDLLSEKLPRLTAHLGQRHVDLSLITFNWFLVIFADSLISDILLRVWDAFLYE 812

  Fly   839 GLPVLFQVAVTLLSIC-ESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKIKKLKQY 902
            |..|:|:.|:.:.... |:.||..|...|.:|.|......|.|...............:|:|:|
  Rat   813 GTKVVFRYALAIFKYNEEAILRLQDSLEIYQYLRFFTKTICDSRKLTSIAFNDMNPFPMKQLRQ- 876

  Fly   903 EEEFLLKKQHKERLEKEAQIYENRFGE--ERR 932
                 |:..|:||||.|.:..|....|  |||
  Rat   877 -----LRAAHRERLEAELRELELLKAEYLERR 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	12/127 (9%)
		DUF3694	429..523	CDD:289256	19/105 (18%)
		TBC	650..858	CDD:214540	61/215 (28%)
		Phage_Gp23	<914..991	CDD:287621	10/21 (48%)
Tbc1d2	XP_006238118.1	PH_TBC1D2A	44..145	CDD:269966	11/54 (20%)
		PH	44..137	CDD:278594	10/46 (22%)
		TBC	621..833	CDD:214540	60/212 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810