Protein Alignment GAPcenA and Rabgap1

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001101311.1
• Gene: Rabgap1 / 311911
• RGDID: 1304691
• Length: 1065
• Species: Rattus norvegicus
• Alignment Length: 1195
• Identity: 430/1195 - (35%)
• Similarity: 614/1195 - (51%)
• Gaps: 225/1195 - (18%)

  Fly     1 MDDNLST---KSSESSITTSGEYEIVTDSNVASPMEQVKQVVNQEGTQPEVGGKPPTSLSALALS 62
            |||..|.   ..|..|::|....:.|              :|:::|.:     .|.|:
  Rat     1 MDDKASVGKISVSSDSVSTLNSEDFV--------------LVSRQGDE-----TPSTN------- 39

  Fly    63 SPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTG 127
              ....|....|.:..|.:...:|.|:.|.|.|..::      .:...:|  ||        |.|
  Rat    40 --NGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMD------DQPGMER--SH--------LDG 86

  Fly   128 SGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGDTT 192
            .|.|.:..::                .|||:           |:..|....:|.:...|.|....
  Rat    87 EGDGPLSNQL----------------SASST-----------INPVPLVGLQKPEMSLPVKSGQG 124

  Fly   193 DEEVSE-----IDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCS 252
            |.|||.     .|:...:|:.:||||.|::|||:||.|..|:|..|.|..: :.|.:|:|:||.|
  Rat   125 DSEVSSPFTPVADEDSVVFNKLTYLGCASVNAPRSEVEALRMMSILRSQCQ-ISLDVTLSVPNVS 188

  Fly   253 EGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDA-LFQCHVFRCHIPEAVN 316
            ||.|.|.|.:.||.||.|.|..|:...||...|.|:.|||||..|.:| ||:.|||||.|.|||:
  Rat   189 EGTVRLLDPQINTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVS 253

  Fly   317 QVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAV 381
            ::...|..||:........|..:|   ..:..||:         :.|.|||||:|...|..::||
  Rat   254 RILYSFATAFRRSAKQTPLSATAA---PQTPDSDI---------FTFSVSLEIKEDDGKGYFSAV 306

  Fly   382 P--RDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGY 444
            |  :||.|||||...||::.|.|:||.:   :.|.||||||:|::|||.|...||||:|:.|||
  Rat   307 PKDKDRQCFKLRQGIDKKIVICVQQTAN---KELAIERCFGLLLSPGKDVRNSDMHLLDLESMG- 367

  Fly   445 IQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN---LTVAVDIVMRRIQE 506
                            :.|....|.|...|..:...|:.:|.|:.|..   :|.|||:|:..:||
  Rat   368 ----------------KSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQE 416

  Fly   507 PVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQ 571
            ||||::||.|.:.|.:| |:...| |||..|..|:|.||:.::.. |.|:.|...|:.    ..:
  Rat   417 PVRFLLETKVRVCSPNE-RLFWPF-SKRSTTENFFLKLKQIKQKE-KKNNADTLYEVV----CLE 474

  Fly   572 SSSLLKMGMNNLSRIVR-------SSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDE 629
            |.|..:......|..||       ||.|.|..:|   |...|.|||||||.|:|||:|::..|:.
  Rat   475 SESERERRKTTASPSVRLPQSGSQSSMIPSPPED---DEEEDNDEPLLSGFGDVSKECAEKILET 536

  Fly   630 WDPILREW--DSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETV 692
            |..:|.:|  :...|||.|:.|||.|||||||.::||.||.......:.:||:||||||:..::.
  Rat   537 WGELLSKWHLNLNVRPKQLSSLVRSGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSA 601

  Fly   693 IQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCV 757
            |.|||:||||||..||:.||.|||:|:|:.|||:|:|.|:|||||.||:||.||||||||.||.|
  Rat   602 ITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSV 666

  Fly   758 LVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTAR 822
            ||.:|:|||||:|:|..||.|:.:.||||||:::.:|.|:.||....:|.|||||||||||:||:
  Rat   667 LVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAK 731

  Fly   823 FPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKV 887
            |||..|||::|:.|.:|:.|:|.||:.||...:.||...||||.||:|||.|||:.||...|:::
  Rat   732 FPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKRL 796

  Fly   888 MKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYE--NRFGEERRKMQ------------- 935
            |:.||..||  ||||::|:|:     |..| |::||..:  .||..|.|::|
  Rat   797 MELACNTKISQKKLKKFEKEY-----HTMR-EQQAQQEDPIERFERENRRLQEANMRLEQENDDL 855

  Fly   936 -------------------AEIDALNKQLTSAKERAVEKE------------------------- 956
                               .:.|||||:|...|::.::.|
  Rat   856 AHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKRRLEEESAQLKEMCRRELDKAE 920

  Fly   957 ---KKHTGIIQEYKQII----QRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDAGNDNAKSDDGK 1014
               ||::.||.:||||.    :|.|:........:.|:...|.:|..|:...        :.:|:
  Rat   921 SEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCDRCRDFF--------NKEGR 977

  Fly  1015 NRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSNTLSELQ 1079
            .:|.:.....::|......:.|   ..::|||||||||.||..||||||.|||.|.|...|||:|
  Rat   978 VKGASSVKGVSDEDTDEEKETL---KNQLRELELELAQTKLQLVEAECKIQDLEHHLGLALSEVQ 1039

  Fly  1080 TNRNSWQPWLSKTFNSLQEKVTTRG 1104
            ..:.:   |.::|.:|::.....:|
  Rat  1040 AAKKT---WFNRTLSSIKTATGVQG 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	59/128 (46%)
		DUF3694	377..523	CDD:463599	59/150 (39%)
		TBC	650..858	CDD:214540	118/207 (57%)
		SMC_prok_B	<876..>1087	CDD:274008	77/278 (28%)
		TPH	<883..>977	CDD:464007	40/161 (25%)
Rabgap1	NP_001101311.1	PTB_Rab6GAP	141..269	CDD:269922	59/128 (46%)
		DUF3694	303..433	CDD:463599	59/149 (40%)
		TBC	559..768	CDD:214540	119/208 (57%)
		SMC_prok_B	785..>1028	CDD:274008	70/259 (27%)