DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006255308.1	Gene:	Tbc1d9 / 304645	RGDID:	1308221	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	850	Identity:	177/850 - (20%)
Similarity:	307/850 - (36%)	Gaps:	279/850 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 GSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVG-HSVFYDCIDA----SPACVEEKQDAMKP 186
            |.|||.:       ..|.....:..||   ||.||. :.:.|...|:    :.||...:
  Rat    36 GGGGGGL-------AGLLVGTLDVVLD---SSARVAPYRILYQTPDSLVYWTIACGGSR------ 84

  Fly   187 EKGDTTDEEVSE--------IDQGCTIFSGVTYLGAANINAPKSETEVY-----RIMGELNSGSK 238
                   :||:|        :.|..:||              ::|.:|.     :|.|.:...:|
  Rat    85 -------KEVTEHWEWLEQNLLQTLSIF--------------ENENDVTTFVRGKIQGIIAEYNK 128

  Fly   239 SVGLKITVSIPNCSEGLVVLHD----AESNTIIATYEISSIILYYRGPVD-------TVENGCFA 292
            ...:|.........|.:|..|.    .|...::..|..|    |::|.|.       ::.:.||:
  Rat   129 INDVKEDEDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCS----YWKGKVPRQGWMYLSINHLCFS 189

  Fly   293 ----------------FTWLHGDALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAV 341
                            .|.|..:|...       :|:.:...:...:..|     |:..::|...
  Rat   190 SFLMGREAKLVIRWVDITQLEKNATLL-------LPDMIKVSTRSSEHFF-----SVFLNINETF 242

  Fly   342 DMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPRD----------RGCF------KL 390
            .:...:.:......|:..|:|...||...::.:....:|:.||          |..|      ||
  Rat   243 KLMEQLANIAMRQLLDNEGFEQDRSLPKLKKKSPKKVSALKRDLDARAKSERYRALFRLPKDEKL 307

  Fly   391 RANTDKEVCITVKQTPSN---VLQPLHIER---CFG-------VLVAPGKLVVQKDMHLIDMHSM 442
            ..:||   |  ...||.|   :|..:.:..   ||.       .|:.|     .:::.:::....
  Rat   308 DGHTD---C--TLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIP-----LREVTIVEKADS 362

  Fly   443 GYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRRIQEP 507
            ..:.|....::|.:                     ...|...||:..        |.:::||.:
  Rat   363 CSVLPSPLSISTRN---------------------RMTFLFANLKDR--------DFLVQRISD- 397

  Fly   508 VRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQS 572
              |:.:|                      |.|.|      .|.:...||.|  :|:..:|
  Rat   398 --FLQQT----------------------TSRIY------SEFSGSCNSSD--DEVYSRP----- 425

  Fly   573 SSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPL-LSGTGEVSKDCSQDTL--------- 627
                       |.:|.||...|...|      :||:.|. |:|.   |...:..||
  Rat   426 -----------SSLVSSSPQRSTSSD------ADGERPFNLNGN---SVPTATQTLMTMYRRRSP 470

  Fly   628 DEWDP-ILREWDSEK----------------RPKNLAPLVRLGVPEALREKIWQKLANVEGRMEM 675
            :|::| :.:|:..|:                |.:....||..|:||.:|.::|..|:..     :
  Rat   471 EEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPERMRGELWLLLSGA-----I 530

  Fly   676 NDK------YKILITKE----TKCETVIQRDIHRTFPAHKCFK-EIGGSGQDALFKVSKAYAVHD 729
            |:|      |:.|:.|.    ......|:||:||:.|.|..|: |:|.:   ||.:|..|||..:
  Rat   531 NEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIA---ALRRVLTAYAFRN 592

  Fly   730 SEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLP 794
            ..:||||.::.:.:.|||:..||:||.:||||. :..|.|.|........:.....|.|.:|.:|
  Rat   593 PNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALC-ERMLPDYYNTRVVGALVDQGVFEELARDYVP 656

  Fly   795 KLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSI------ 853
            :|::.....|:.:.:..| |||||:.:..|......|:|.|..:|:.|:||:|:.:|..
  Rat   657 QLYDCMQDLGVISTISLS-WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLL 720

  Fly   854 -CESD 857
             |:.|
  Rat   721 GCKDD 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	24/159 (15%)
		DUF3694	429..523	CDD:289256	10/93 (11%)
		TBC	650..858	CDD:214540	69/225 (31%)
		Phage_Gp23	<914..991	CDD:287621
Tbc1d9	XP_006255308.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	14/113 (12%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	21/136 (15%)
		TBC	510..720	CDD:214540	68/219 (31%)
		EFh	<891..921	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810