DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Evi5l

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_038945835.1	Gene:	Evi5l / 304201	RGDID:	1561962	Length:	815	Species:	Rattus norvegicus

Alignment Length:	587	Identity:	174/587 - (29%)
Similarity:	291/587 - (49%)	Gaps:	67/587 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 TEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPL 611
            ::..|...:.::...::.||....::.|.....||...|...||.::|      |..||:
  Rat    30 SDSENLSPDELELLAKLEEQNRLLEADSKSMRSMNGSRRNSGSSLVSS------SSASSN----- 83

  Fly   612 LSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKN--LAPLVRLGVPEALREKIWQKLANVEGRME 674
            ||       ...:||...|..|..||:..:|.|.  |..|:|.|:|...|..:||.|.:... |.
  Rat    84 LS-------HLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATD-MP 140

  Fly   675 MNDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLS 739
            :.::|..|:...:.||.:|:|||.||:|.|:.||.....||:.||.|.|||::.|.|||||||.:
  Rat   141 VKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSA 205

  Fly   740 FIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACG 804
            ||...||:.||||:||||.|.||.:|.||:|:|.....|.|.:||.|.::::|||.|:.||.:..
  Rat   206 FIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQS 270

  Fly   805 IETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKY 869
            ..|.||||.|||||:...|||.....|.|:|:.:||.::|:|.:.||.:.:::|.|||.||:.:|
  Rat   271 FHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQTELMQLDMEGMSQY 335

  Fly   870 FRVTLPKKCRSSSQARKVMKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERR 932
            |:..:|.:..|...  |::.:|.:.|.  ||:|:.|:|:...|..    |.|.||...|...|.|
  Rat   336 FQRVIPHQFDSCPD--KLVLKAYQVKYNPKKMKRLEKEYAAMKSK----EMEEQIEIKRLRTENR 394

  Fly   933 KMQAEIDALNKQLTSAKERAVE------KEKKHTGIIQEYKQIIQRQ----EQDMNTLSETLGKV 987
            .::..|:.|.|:..:..:|.::      :|.:...:|:....::::|    .:|:.....|:.::
  Rat   395 LLKQRIETLEKESAALADRLIQGQVTRAQEAEENYVIKRELAVVRQQCSSTAEDLQKAQSTIRQL 459

  Fly   988 MHMVSN---CQDCQQQIDAGNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAA---SQRIREL 1046
            .....|   .:|....::...:.::..:.:..|   |:|...:..| .::..|::   ...:..|
  Rat   460 QEQQENPRLTEDFVSHLETELEQSRLRETETLG---ALREMQDKVL-DMEKRNSSLPDENNVARL 520

  Fly  1047 ELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSK-----------TFNSLQEKV 1100
            :.||...|:.:.||....::|..|       ||...::||..:|:           ....||:::
  Rat   521 QEELKALKVREGEAVASARELKLQ-------LQELSDTWQAHVSRGGRWKESPRKLVLGELQDEL 578

  Fly  1101 TT 1102
            .|
  Rat   579 MT 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	91/207 (44%)
		Phage_Gp23	<914..991	CDD:287621	16/86 (19%)
Evi5l	XP_038945835.1	TBC	117..325	CDD:214540	91/208 (44%)
Evi5l	XP_038945835.1	SMC_prok_B	<381..719	CDD:274008	38/211 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920