DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Sgsm2

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006246802.1	Gene:	Sgsm2 / 303304	RGDID:	1306957	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	186/968 - (19%)
Similarity:	314/968 - (32%)	Gaps:	334/968 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DNLSTKSSESSIT--TSGEYE----IVTDSNVASPMEQVKQV-------------VNQEGTQPEV 48
            :||:.|.:.:.:.  |.|:.|    :..|..:..|..|:..|             |:|:|.|
  Rat   287 ENLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQIVCVHCHQQKSGGTLVLVSQDGIQ--- 348

  Fly    49 GGKPPTSLSALALSSPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLE-LERGVAASGEKSAQR 112
              :||       |..|:.|                       ..|..|. ||.|:...|:
  Rat   349 --RPP-------LHFPQGG-----------------------HLLSFLSCLENGLLPRGQ----- 376

  Fly   113 LPSHQQKSLTLPL-TGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRV------GH-----SV 165
                    |..|| |..|.|.|.|::|...::.:..:|| |....:::.|      ||     ::
  Rat   377 --------LEPPLWTQQGKGKVFPKLRKRSSIRSIDAEE-LGVGRATDYVFRIIYPGHRHEHITI 432

  Fly   166 FYDCIDASPACVEEKQDAMKPEKGDTTDEEVSEIDQGCTIFSGVTYLGAANINAP---KSETEVY 227
            .|..:.||.|.              :.|::..|.|:   :.:.::.:.:.|:.||   |...::.
  Rat   433 NYHHLAASRAA--------------SVDDDEEEEDK---LHAMLSMICSRNLTAPNPMKDAGDMI 480

  Fly   228 RIMGELNSGSKSVGLKITV--SIPNCSEGLVVLHDAESNTIIA-------TYEISSIILYYRGPV 283
            .:.|        .|..:|.  ..|.||:|...|....|::..|       |.:...:.|......
  Rat   481 EMQG--------FGPSLTAWHLEPLCSQGSSCLSCPSSSSPYAPPSHCSCTPDRLPLRLLCESMK 537

  Fly   284 DTVENGCFAFTWLHGDALFQCHVFRCHIPEAVNQVSACFQKAF--QTYPPSMSCSLNSAVDMANS 346
            ..:.:..| :.||         .:..|:......:||......  ...||..|..|      ...
  Rat   538 RQIVSRAF-YGWL---------AYCRHLSTVRTHLSALVHHNIIPPDRPPGASGGL------TKD 586

  Fly   347 VTSDVSGNPLNTAGYEFI-------VSLEIRERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQ 404
            |.|....:..|....|.:       |..|||:.|       .|...|.:|
  Rat   587 VWSKYQKDKKNYKELELLRQVYYGGVEHEIRKDV-------WPFLLGHYK--------------- 629

  Fly   405 TPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYT 469
                          ||        :.:|:|..:|           ..||    :..||
  Rat   630 --------------FG--------MSKKEMEQVD-----------AAVA----ARYQQ------- 650

  Fly   470 IRAEWKAQEKAFEQLNLESSKTNLT-----VAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDH 529
            :.|||||.|....|...|:....||     .::|..::|:       :....||.:       |.
  Rat   651 VLAEWKACEVVVRQREREAHPATLTKFSSGSSIDSHVQRL-------VHRDSTISN-------DV 701

  Fly   530 FMSKRPMTLRFYLHLKRTEESNWKVNSID---PSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSS 591
            |:|                     |:.::   |.:....:|..::.......|       ..::.
  Rat   702 FIS---------------------VDDLEPPGPQDPEDSKPKQEREPGAGTPG-------TAAAE 738

  Fly   592 IASIEDDCP-SDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVR---- 651
            ..|:|.:.| |...|..:..:.||.        |.:|||...:..|.|......:..|...
  Rat   739 QQSVEFESPDSGLPSSRNYSVASGI--------QSSLDEAQSVGFEEDGAGEEGSEEPATAAHTF 795

  Fly   652 LGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETV------IQRDIHR--------TFP 702
            ||..:..:||: ...:.:||..|:........|.|. .:||      |.:|:.|        |.|
  Rat   796 LGPHDPDQEKL-APASELEGGEELTAVCAATYTIEL-LDTVALNLHRIDKDVQRCDRNYWYFTTP 858

  Fly   703 AHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEED-AFCVLVALMY--- 763
                       ..:.|..:..:|.....::||.||:..:.|.||:.:..:. |:.....||.
  Rat   859 -----------NLERLRDIMCSYVWEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMS 912

  Fly   764 ----DYGLRDLYKAG----FEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMY-ASQWFLTLY 819
                :.|..|.:.|.    .::|...|::|          :|::    |..||.| ..:|||..:
  Rat   913 QNFPNGGAMDTHFANMRSLIQILDSELFEL----------MHQN----GDYTHFYFCYRWFLLDF 963

  Fly   820 TARFPLCFVFHVLDVF-----LLDGLPVLFQVAVTLLSICESDLR--QLDFEGILKYF 870
            ........||.|.:|.     :.....||| :|:.|:......:|  .:||..|:|:|
  Rat   964 KRELLYEEVFAVWEVIWAARHISSEHFVLF-IALALVEAYREIIRDNNMDFTDIIKFF 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	23/141 (16%)
		DUF3694	429..523	CDD:289256	21/98 (21%)
		TBC	650..858	CDD:214540	51/243 (21%)
		Phage_Gp23	<914..991	CDD:287621
Sgsm2	XP_006246802.1	RUN	42..189	CDD:280855
		PH_RUTBC	256..424	CDD:275431	38/185 (21%)
		TBC	<838..1006	CDD:214540	40/193 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900