DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and Tbc1d30

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_038936067.1	Gene:	Tbc1d30 / 299824	RGDID:	1305255	Length:	946	Species:	Rattus norvegicus

Alignment Length:	764	Identity:	155/764 - (20%)
Similarity:	273/764 - (35%)	Gaps:	235/764 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 QSASEMRIMDHFMSKRPMTLRFYL-HLKRTEESNWKVNSIDPSEEITEQPGHQQSSSL--LKMGM 580
            :.|.:.|::.. :.:|| :||..: :|:|.:.|..|.    ...|:..:.|.|.:..|  ||...
  Rat   158 RGAGDSRVLQE-LRERP-SLRLQMQYLERKDSSELKT----ILRELKSRVGIQSAKLLRQLKQKD 216

  Fly   581 NNLSRIVRSSSIASIEDDCPSDYSSDGD-EPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPK 644
            ..|.::.::..|.:.   |....|.... :..|..|.|.|  ..|:...:|      :|:.|...
  Rat   217 RLLHKVQKNCDIVTA---CLQAVSQKRRVDTKLKFTLEPS--LGQNGFQQW------YDALKAVA 270

  Fly   645 NLAPLVRLGVPEALREKIWQKLA-----------NVEGRMEMNDKYKILITKETKCETVIQRDIH 698
            .|:    .|:|:..|.|:|..||           :...|...|::..   ..:......|.:|:|
  Rat   271 RLS----TGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSN---PDDDSMGIQIVKDLH 328

  Fly   699 RTFPAHKCFKEIGGSGQD--ALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMP--EEDAFCVLV 759
            ||..:..|.:|   :.||  .|.:|..|||..:..||||||.:.:||.:|..|.  |.||..:::
  Rat   329 RTGCSSYCGQE---AEQDRVVLKRVLLAYARWNKNVGYCQGFNILAALILEVMEGNEGDALKIMI 390

  Fly   760 ALMYDYGLRDLYKA-GFEVLYLRLYQLERLIKDQLPKLHEHF----------TACGIE---THMY 810
            .|: |..|.:.|.. ....|.:.:.....|::.:||:|.:|.          :..|.|   |:::
  Rat   391 YLI-DKVLPESYFVNNLRALSVDMAVFRDLLRLKLPELSQHLDTLQRTSNKESGGGYEPPLTNVF 454

  Fly   811 ASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTL-------LSICES------------ 856
            ..||||||:....|...|..:.|....:|..::.:|::.:       :..||:
  Rat   455 TMQWFLTLFATCLPNHTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCETADEFYGTMGRLT 519

  Fly   857 ------DLRQ-------------LDFEGIL----KY-FRVT-LPKKCRSSSQARKVMKQ------ 890
                  ||.|             ..|..:.    || :.:| .|...:.:|.:.:..|.
  Rat   520 QEMLEHDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATIKPTSVSGRHSKSRDSDDE 584

  Fly   891 -------------AC------------ERKIKKLKQYEEEFLLKKQHKERLEKEA-----QIYEN 925
                         .|            ::..|::|:..||..|:..:...|...|     ..|..
  Rat   585 NGPDDEDAVASAVGCLGPLSGLLAPELQKYQKQIKEGTEEQTLRSNNIAELSPGAINSCRSEYHA 649

  Fly   926 RFGE-ERRKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQEYK----QIIQRQEQDMNTLSE-TL 984
            .|.. ...:|..:|:||.:|.:..|::  ::::.|...|:..|    .|:..|......::. .|
  Rat   650 AFNSMMTERMTTDINALKRQYSRIKKK--QQQQLHQVYIRADKGPVTSILPSQANSSPVINHLLL 712

  Fly   985 GKVMHMVSNCQDCQQQIDAGNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELE 1049
            ||.|.:.                       ||...:|:.:...|..|.:.|:
  Rat   713 GKKMKIT-----------------------NRAAKNAVIHMPGHAGGKISPV------------- 741

  Fly  1050 LAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTRGGHRDNGSGGP 1114
                                    ...:::|..||  ||.:..      :|     |:.|
  Rat   742 ------------------------PYEDIKTKLNS--PWRTHI------RV-----HKKN----- 764

  Fly  1115 MPSFQSYMGQAPTT-LSEASSPSGNQEYKTFAFASVGGSPKLPSKFQAT 1162
            ||..:|::|...|. |.|..    |:..||   :|:|.:.:.||....|
  Rat   765 MPRTKSHLGCGDTVGLIEEQ----NEGCKT---SSLGAAEEFPSSCAVT 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	1/3 (33%)
		TBC	650..858	CDD:214540	62/261 (24%)
		Phage_Gp23	<914..991	CDD:287621	19/87 (22%)
Tbc1d30	XP_038936067.1	TBC	273..494	CDD:214540	60/231 (26%)
Tbc1d30	XP_038936067.1	DUF4682	663..791	CDD:406220	38/214 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910