DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and Rabgap1l

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006496938.1	Gene:	Rabgap1l / 29809	MGIID:	1352507	Length:	1051	Species:	Mus musculus

Alignment Length:	1115	Identity:	399/1115 - (35%)
Similarity:	569/1115 - (51%)	Gaps:	193/1115 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 TDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTGSGGGSVDPEMRFPCTLFTPKSEETLDD 154
            :|::..|..|..|..|....|..:....:..  |.:..:|...::..|           ||.|.|
Mouse    14 SDSVATLNSEEFVLVSQHTDATSIKDDGKPQ--LKIASNGDEQLEKAM-----------EEILRD 65

  Fly   155 ASSSNR------VGHSVFYDC----IDASPACVEEKQDAMKPEKGDTTDEEVSE----IDQGCTI 205
            :.....      .|.|...||    :.||.......|..:.|...:.:....|.    .::...:
Mouse    66 SEKGQSGLPVDCQGSSEISDCPFGDVPASQTTKPPLQLILDPSNTEISTPRPSSPSRFPEEDSVL 130

  Fly   206 FSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCSEGLVVLHDAESNTIIATY 270
            |:.:||||...:::|:||.|..|.|..:.:.|: ....:|:.:||..||.|.:.|..||..||::
Mouse   131 FNKLTYLGCMKVSSPRSEVEALRAMATMRASSQ-YPFAVTLYVPNVPEGSVRIIDQSSNVEIASF 194

  Fly   271 EISSIILYYRGPVDTVENGCFAFT-WLHGDALFQCHVFRCHIPEAVNQVSACFQKAFQTYPPSMS 334
            .|..::...||...|.|:.||||| ..||...||.|||.|.|.|||:::...|..||:.
Mouse   195 PIYKVLFCARGHDGTAESNCFAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFKR------ 253

  Fly   335 CSLNSAVDMANSV----TSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAVPRDRG--CFKLRAN 393
             |.....|:.:||    .|||         :.|.||||::|...|.:::.||:||.  .||::..
Mouse   254 -SSRQVSDVKDSVIPTPDSDV---------FTFSVSLEVKEDDGKGNFSPVPKDRDKFYFKIKQG 308

  Fly   394 TDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGYIQPGGTGVATESDS 458
            .:|:|.|||:|. ||  :.|.||||||:|::||:.|...||||:||.|||....|..
Mouse   309 IEKKVVITVQQL-SN--KELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDGRA-------- 362

  Fly   459 NAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN---LTVAVDIVMRRIQEPVRFVIETPVTIQS 520
                     |.|...|......|..||.|:.|..   :|||||:|:..:.|||||::||.|.:..
Mouse   363 ---------YVITGMWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYP 418

  Fly   521 ASEMRIMDHFMSKRPMTLRFYLHLKRTE--------ESNWKVNSIDPSEEITEQPGHQQSSSLLK 577
            |:| |..  :.|::..|..|::.||::|        ::.::|.|:. .|...|:|
Mouse   419 ANE-RFW--YFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQ-RESDKEEP---------- 469

  Fly   578 MGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSE-- 640
                 ::.......::..||:.    ..:.|..|.||||:|||||.:..|..|..:|..|.:.
Mouse   470 -----ITPTSAGGPMSPQEDEA----EEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLG 525

  Fly   641 KRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVIQRDIHRTFPAHK 705
            .|||.|..||:.|||||||.::||.||......||.|||:|||||::..|:||.||||||||||.
Mouse   526 GRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRILITKDSAQESVITRDIHRTFPAHD 590

  Fly   706 CFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDL 770
            .||:.||.||::|:|:.|||:|.|.::|||||.||:||.||||||||.||||||.:||.|.||||
Mouse   591 YFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVTIMYGYKLRDL 655

  Fly   771 YKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVF 835
            |:..||.|:.:.||||:|:::|||.|:.||....:|.|||||||||||:||:||||.|||::|:.
Mouse   656 YRNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL 720

  Fly   836 LLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKI--KK 898
            |.:||.::|.||:.||...:.||.|.||||.||:|||.|||:.|:...||::|:|||..|:  ||
Mouse   721 LCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKK 785

  Fly   899 LKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQA--------------------------- 936
            ||:||:|:  :...:.:|::|..:  :|:..|.|::|.
Mouse   786 LKKYEKEY--QAMRENQLQQEDPM--DRYKRENRRLQEASMRLEQENDDLAHELVTSKIALRNDL 846

  Fly   937 -----EIDALNKQLTSAKERAVEKE----------------------------KKHTGIIQEYKQ 968
                 :.|.|||:|...|:|.||.|                            ||.|.||.||||
Mouse   847 DQAEDKADVLNKELLFTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQ 911

  Fly   969 IIQ----RQEQDMNTLSETLGKVMHMVSNCQDCQQQIDAGNDNAKSDDGKNRGQTDAMR-NANEH 1028
            |..    |.|:......|.|..|...:..|:.|            ||.....|....:. |..:.
Mouse   912 ICSQLSTRLEKQQAASKEELEAVKGKMMACKHC------------SDIFSKEGALKPVAVNREDQ 964

  Fly  1029 PLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTF 1093
            .|...|..::..:::||:||||||.||..|||:||.|:|.||....::|:|..:||   |.|||.
Mouse   965 GLEADDEKDSLKKQLREMELELAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNS---WFSKTL 1026

  Fly  1094 NSLQEKVTTR 1103
            ||::....|:
Mouse  1027 NSIKTATGTQ 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	48/128 (38%)
		DUF3694	429..523	CDD:289256	34/96 (35%)
		TBC	650..858	CDD:214540	123/207 (59%)
		Phage_Gp23	<914..991	CDD:287621	31/140 (22%)
Rabgap1l	XP_006496938.1	PTB_Rab6GAP	129..257	CDD:269922	49/135 (36%)
		DUF3694	290..421	CDD:372133	58/150 (39%)
		RabGAP-TBC	541..744	CDD:366170	120/202 (59%)
		Smc	<814..>1019	CDD:224117	56/216 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	621	1.000	Inparanoid score	I876
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49205
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm43139
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3994
SonicParanoid	1	1.000	-	-		X1488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.970