DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and Usp6nl

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_006254294.1	Gene:	Usp6nl / 291309	RGDID:	1311786	Length:	833	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	135/596 - (22%)
Similarity:	243/596 - (40%)	Gaps:	108/596 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 PLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANV-EGRM 673
            |..:...:..|....:...:|..:|:.|:..|..:.....:..|:|..||.::|..|..: :.:.
  Rat    74 PYPNAAADRQKQLEIERTSKWLKMLKRWERYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKE 138

  Fly   674 EMNDKYKILITKETKCETVIQR---DIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYC 735
            |..|.|..|..:...|...|::   |::|||..|..|::..|..|.:||.|..||:::::|||||
  Rat   139 ETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYC 203

  Fly   736 QGLSFIAASLLLHMPEEDAFCVLVALMY--DYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHE 798
            ||:|.|.|.||::|.|||||..||.|..  .:.:...:..||..|.......|:::...|.||.:
  Rat   204 QGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQ 268

  Fly   799 HFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDF 863
            |..:..|.|..|..:||...:..|.|......:.|:::.:|..:|..::.|:|.:....|.:|..
  Rat   269 HLDSQEIYTSFYTMKWFFQCFLDRTPFRLNLRIWDIYIFEGERILTAMSYTILKLHRKHLMKLSM 333

  Fly   864 EGILKYFRVTLPKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLE-KEAQIYENRF 927
            |.::::.:.||.|..                      .:|::|::::......| |.|::.....
  Rat   334 EELVEFLQETLAKDF----------------------FFEDDFVIEQLQVSMTELKRAKLDLPEP 376

  Fly   928 GEERRKMQAEIDALNKQLT---SAKERAVEKEKKHTGIIQEYKQIIQRQE--------------Q 975
            |:|....:..:..|..:.|   |..:|:|.:..         .:|..|:|              .
  Rat   377 GKEDEYPRKPLGQLPPEYTNHLSNGQRSVGRPS---------PKISSRREDGSPHKAHEHSPAHH 432

  Fly   976 DMNTLSETLGKVMHMVSNCQDCQQQIDAGNDNAK-------------SDDGKNRGQTDAMRNANE 1027
            ..|...|.:|         |..::.:|.|:.|.|             .|:.|:.....|.:|:|
  Rat   433 SRNGTPERVG---------QSRRKSVDEGSKNLKQEADFQRKPSSGTQDNSKHYNHATANQNSN- 487

  Fly  1028 HPLGPLDPLNAASQRIRELEL----ELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPW 1088
                       |...||:..:    :.::|...:..|:...:..:|.:...||....  :|.:..
  Rat   488 -----------ALSNIRKEFVPKWRKPSEASAIERTAKYAIEGRSHSVFPALSVAVP--SSAETR 539

  Fly  1089 LSKTFNSLQEKVTTRGGHRDNGSGGP----MPSFQSYMGQAPTTLSEASSPSGNQEYKTFAFASV 1149
            ||   ||.|:.....||..:.||...    :|..:|..|.:.....|.:.|...:::     :..
  Rat   540 LS---NSRQKMKAFDGGEGNRGSNASQYDNVPGSESEPGASAEEGPERTHPHSPRKH-----SEP 596

  Fly  1150 GGSP-KLPSKF 1159
            ..|| |:|:||
  Rat   597 SPSPSKVPNKF 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	66/213 (31%)
		Phage_Gp23	<914..991	CDD:287621	16/94 (17%)
Usp6nl	XP_006254294.1	TBC	114..329	CDD:214540	66/214 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810