DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPcenA and TBC1D28

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_016879905.1	Gene:	TBC1D28 / 254272	HGNCID:	26858	Length:	350	Species:	Homo sapiens

Alignment Length:	166	Identity:	36/166 - (21%)
Similarity:	64/166 - (38%)	Gaps:	24/166 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 GHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDP 632
            ||:|..  ::...|||. ||....:                 |.:|......:.......::|..
Human    77 GHEQVD--VRKYTNNLG-IVHEMEL-----------------PRVSALEVKQRRKESKRTNKWQK 121

  Fly   633 ILREWDSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMN-DKYKILITKETKCETV---I 693
            :|.:|...:..|.|:..|...:|.|:|.:....|.:::.....| .|||::..|..:...:   |
Human   122 MLADWTKYRSTKKLSQRVCKVIPLAVRGRALSLLLDIDKIKSQNPGKYKVMKEKGKRSSRIIHCI 186

  Fly   694 QRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHD 729
            |.|:..|...|..|.:..|..|..|..:..||:.::
Human   187 QLDVSHTLQKHMMFIQRFGVKQQELCDILVAYSAYN 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	21/84 (25%)
		Phage_Gp23	<914..991	CDD:287621
TBC1D28	XP_016879905.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910