Protein Alignment GAPcenA and gyp51

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_594886.1
• Gene: gyp51 / 2542680
• PomBaseID: SPAC26F1.09
• Length: 1031
• Species: Schizosaccharomyces pombe
• Alignment Length: 1200
• Identity: 246/1200 - (20%)
• Similarity: 410/1200 - (34%)
• Gaps: 401/1200 - (33%)

  Fly     7 TKSSESSITTSGEYE---IVTDSNVASPMEQVKQVVNQEGTQPEVGGKPPTSL------------ 56
            |:::|..:.:|.|.|   |:.:.. |...|....:..::||    |..|..:.
pombe     4 TEANEREVQSSYEKENVKIIREEE-AKDQESTDDIAVEDGT----GTSPDLNFFSTQNVMQMNFE 63

  Fly    57 ---SALALSSPEAGGDRS--------PTL-DM-------AHNRNLSDMQHEMTDALKDLEL-ERG 101
               |..:....||..|.|        |.: ||       :|::...:.|:..|:..:|..: |..
pombe    64 DEYSEFSNEDDEAEIDNSFADSIPNEPEIPDMQDEYSRDSHSQQSVEEQNNTTNTDEDASVNEFS 128

  Fly   102 VAA----------SGEKSAQRLPSHQQKSLTLPLTGSGGGSVDPEMRFPCTLFTPKSEETLDDAS 156
            |||          ...:|.:...:...::.||     |...|.....||        .|.||:..
pombe   129 VAADISDVNTLGKDNSESTEEPVNEVNETATL-----GNEDVGERSGFP--------SEGLDNEP 180

  Fly   157 SSNR----VGHSVFYDCIDASPACVE--EKQDAMKPEKGDTTD--------EEVSEID------- 200
            .|.|    .|:....|..|...:..|  |..|..:.|:..:.|        |:|:||:
pombe   181 ESQRDLDETGNLAPEDLKDEVKSVHEFNEPNDLRQQEESYSDDDDTNVNEFEDVNEIENEHQLSV 245

  Fly   201 ----------QGCTIFSGVTYLG-AANI--------NAPKSETEVYRIMGELNSGSKSVGLKITV 246
                      :|..||.|....| .|:|        |.|.|:|              ..|.|.|.
pombe   246 ADEDQTSRLVKGKMIFVGKEDFGEEADISNSVFIEQNGPNSDT--------------VSGFKETS 296

  Fly   247 SIPNCS---EGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDALFQCHVFR 308
            ||.|.|   |...|..|::::|.|...|
pombe   297 SIVNSSSTTEKPGVALDSQNDTSIFNEE------------------------------------- 324

  Fly   309 CHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSD-----VSGNPLNTAGYEFIVSLE 368
                              ||         ||..:..|.:|.|     |...|:  ||.|
pombe   325 ------------------QT---------NSLTETFNDLTLDHLPENVESEPV--AGKE------ 354

  Fly   369 IRERVAKNSYAAVPRDRGC----FKLRANTD----KEVCITVKQTPSNVLQPLHIERCFGVLVAP 425
              ...|||...|...|...    |.|:::.|    .|..|..:..|.....|        ::.:.
pombe   355 --NETAKNESGASDNDHKANVHVFVLKSSEDAITLNEEKIATQDDPLEAPTP--------IVASS 409

  Fly   426 GKLVVQKDMHLIDMHSMGYIQP---GGTGVATES---DSNAQQSSSWP--------------YTI 470
            ..:.:..:....::.:.|..:|   .||. :|.|   |:|...:|..|              .||
pombe   410 STIFLNSNQRNDELSASGSQEPHPKDGTN-STSSLPLDTNNLSNSEPPSHVLDASSETIEVIQTI 473

  Fly   471 RAEWKAQEKAFEQLNLESSKTN--LTVAVDIVMRRIQEPVRFV---IETPVTIQSASEMRIMDHF 530
            :   |.|.:..|.:..|..|.|  .:....:....::...|..   ..:|.:...:|.:..:.:.
pombe   474 K---KLQNQVPETIKDEVGKKNTAFSPGTSLSTNHVKTKSRSAHNNSTSPFSTAVSSWLNPLRYP 535

  Fly   531 MSKRPMTLRFYLHLKRTEESNW--KVNSIDPSE--EITEQPGHQQSSSLLKMGMNNLSRIVRSSS 591
            ..|.|..:..||      ||.:  |..||..::  ||.|.. ..|||::.......||..:::..
pombe   536 SDKSPRVISSYL------ESVFISKPRSIGDAQKLEILEYL-QSQSSTVSNQVFTLLSNFIQNPL 593

  Fly   592 IASIEDDCPSDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVRLGVPE 656
            .  :.|:|                           .||:             :|   |:.:....
pombe   594 F--VLDEC---------------------------FDEF-------------RN---LILMHNSH 613

  Fly   657 ALREKIWQKLAN-VEGRMEMNDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDA--- 717
            .:...:|:.::: .....||  :|..|..|....:..|::|:.||| |.:.......:.|..
pombe   614 TVHTVVWKTISSWTSYDYEM--QYSSLSIKNCDSDKAIRKDLDRTF-APEILSHFFSNRQQLEPT 675

  Fly   718 ---------LFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKA 773
                     |.:|.::.|:...:|||.||:|:||.:||:|:|...||.:||.|..:|.|::::.:
pombe   676 DNIAESTANLHRVLRSLAIVLPQVGYTQGMSWIAGALLMHLPAPQAFALLVFLFKNYHLQNIFSS 740

  Fly   774 GFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLD 838
            ....|...|:|..||::|.:|.|..||....|:|..|||:|||||:..:|||..|.|:.|:..|.
pombe   741 EMRGLSRVLHQFTRLVEDYMPSLAIHFKRQDIKTCSYASEWFLTLFAYKFPLEVVAHLYDILFLY 805

  Fly   839 GLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARK-----VMKQACERKIKK 898
            |..:||...:.|||..:..|.:|:.:.::.|.:..:....:.:.:...     .:|.|...:|:.
pombe   806 GPGILFNFGLALLSHSQESLLKLNMDRLISYLKEDIFLAFKETQEGENYDTSLFVKTAFSFEIQP 870

  Fly   899 --LKQYEEEF--LLKKQHKERLEKEAQIYENRFGE------------------------------ 929
              |.:|..|:  |||.:|:  |:...:...||...
pombe   871 DVLDRYGNEYDILLKSEHE--LDSSLEEMRNRHKSLNEHFIMLSDSMANLQVEHENMSALLLKEK 933

  Fly   930 --------ERRKMQAEIDALNKQLTSAK-------------------ERAVEKEKKHTGIIQEYK 967
                    |:..:::||.:||.||...|                   |..||.:.....|.::.|
pombe   934 MYLKNQTVEQASLKSEIASLNSQLAKQKSEIEQAFQGDMEAIIAENLEIMVESQSLEDEIFRKEK 998

  Fly   968 QI-----------------IQRQEQDMNTL 980
            |:                 :|:..|.||.:
pombe   999 QLAETKVNLAVLDEDHMMALQKWSQLMNRI 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	25/139 (18%)
		DUF3694	429..523	CDD:289256	20/118 (17%)
		TBC	650..858	CDD:214540	68/220 (31%)
		Phage_Gp23	<914..991	CDD:287621	21/140 (15%)
gyp51	NP_594886.1	COG5210	233..890	CDD:227535	176/813 (22%)
		TBC	569..826	CDD:214540	79/305 (26%)
		PspA	889..>1024	CDD:224755	18/136 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I1618
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm47026
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1488
TreeFam	0	0.000	Not matched by this tool.
	6	5.810