DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and SPCC1620.12c

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001342783.1	Gene:	SPCC1620.12c / 2538866	PomBaseID:	SPCC1620.12c	Length:	640	Species:	Schizosaccharomyces pombe

Alignment Length:	704	Identity:	136/704 - (19%)
Similarity:	259/704 - (36%)	Gaps:	174/704 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 ESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYL-HLKRTEES 550
            :|...:|:.|::.|....||.::..::....: |.......:|  |.:.::|.:.. .|::|||.
pombe     3 KSVNASLSSAINSVTLVKQENLKENLQNGSAV-SVGSSESSNH--SMKEISLDYSSPSLQQTEEQ 64

  Fly   551 NWKVNSID-------PSEE-----ITEQP------GHQQSSSLLKMGMNNLSRIVRSSSIASIE- 596
            :.::|.||       |.:|     ..|:|      ||....|.:.....|:|    ||.|.:.:
pombe    65 DRELNFIDSSMLRPTPPQESDNRLAVEKPNIQPLQGHSPVPSFMSTASTNIS----SSKINNNQT 125

  Fly   597 --DDCPSDYSSDG-------DEPLLSGTGEVSKDCSQDTLD-------EWDPI-LREWDSEKRPK 644
              :.....|.|.|       |..:.|...|:::.|.::::.       :|..: |..:|....|.
pombe   126 EFEQLRDSYKSHGDLNSAINDSRIQSIIFELNQQCEKESIPVSNIDWLQWASVPLFAYDLPPDPS 190

  Fly   645 N----------LAPLVRL------GVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVI 693
            |          |.|::.|      .:|...|:.:||.|.:.| |.|:...|..|.|.....::.|
pombe   191 NPNATSSSPPPLTPILELIKQNNFCIPSPCRKLVWQSLVSAE-RNELLTLYATLSTTNNSLDSSI 254

  Fly   694 QRDI-------------HRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGY-CQGLSFIAAS 744
            ::.|             :.:...||...|       ::|.|..|:.:.|:.|.| .:.|.::..:
pombe   255 RKIIRMQSFRGPLEPFKYSSTTRHKVSTE-------SIFHVLHAFTLFDTTVEYNIEPLLWLTCA 312

  Fly   745 LLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLY----------------QLERLIKDQL 793
            .|.:|.:.:||..||..:...|:|:.:.:....|...|:                .|:|:....|
pombe   313 FLSYMAQGNAFRSLVCFIQRGGIREFFISQSSSLDESLFALVWGCLGDLAPSVAISLQRIKVSSL 377

  Fly   794 PKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTL-LSICESD 857
            ..|:.....|               :.....|.....::|:..:.||.:..::.|.: |...:..
pombe   378 CILYPSLACC---------------FADSLQLPEALRLMDLIAIYGLEMFVRLLVAIFLKDRDKI 427

  Fly   858 LRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQA-CERKIKKLKQYEEEFLL----KKQHKERLE 917
            :..:..|..:||.|    ....:|.:...|.|.. ..|....|..:.|:.|.    ..|....|.
pombe   428 VNMVSHEQWVKYLR----SDVLASYRQPLVQKYTFYTRTPVDLNAWVEDSLALNIDTTQFPSYLS 488

  Fly   918 -KEAQIYENRFGEER-RKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTL 980
             .|..:..|.:.:.. .:::.:.|.|..|:|:.:|..|...|::|                  .|
pombe   489 YHETSVSHNTYRQNNLEELKNQNDYLTSQITNLEEGMVMLNKENT------------------KL 535

  Fly   981 SETLGKVMHMVSNCQDCQQQIDAGNDNAKSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRE 1045
            ||.|       ||.:..:.:::...:..|::....:.|.:......|:.|  |..::...||.::
pombe   536 SEAL-------SNHRVTRSEMEEATEILKNNSADLKAQLEKQPQELENRL--LQEISILKQRNQK 591

  Fly  1046 LELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQEK 1099
            . |:.....:.|:      |.|:.:|..||.:|               |.|:||
pombe   592 F-LKNNATSIQQI------QYLDEELGKTLKQL---------------NDLKEK 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	7/35 (20%)
		TBC	650..858	CDD:214540	45/244 (18%)
		Phage_Gp23	<914..991	CDD:287621	15/78 (19%)
SPCC1620.12c	NP_001342783.1	COG5210	29..500	CDD:227535	97/504 (19%)
SPCC1620.12c	NP_001342783.1	DUF812	<500..636	CDD:310341	33/173 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810