Protein Alignment GAPcenA and Tbc1d8b

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001074968.1
• Gene: Tbc1d8b / 245638
• MGIID: 1918101
• Length: 1114
• Species: Mus musculus
• Alignment Length: 530
• Identity: 130/530 - (24%)
• Similarity: 216/530 - (40%)
• Gaps: 138/530 - (26%)

  Fly   538 LRFYLHLKRTEESNWKV-NSI--DPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDC 599
            ||..|.:.:|::||..| .||  ..:...:|....:|..:.|::          ....||.:||.
Mouse   343 LREVLAIDKTDDSNRSVIISIKGKTAFRFSELKDFEQLVAKLRL----------KCRAASTQDDV 397

  Fly   600 PSD--YSSDG--------DEPLLSGTGEVSKDCSQ----------------DTLD---------- 628
            .::  .|||.        ::||     ...|:||:                :.||
Mouse   398 STEVAVSSDSTGPSENFEEQPL-----TCPKECSKTVNTEALMTVFHPQNLENLDSKMLKEKMKE 457

  Fly   629 -EWDPILREWD---SEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKY---------- 679
             .|:.:..|..   |..|.|....||..|:||.||.::|...:.....|..|..|
Mouse   458 QSWNILFSECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPGYYAEVVEQSLG 522

  Fly   680 -KILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAA 743
             ..|.|:|      |:||:.|:.|.|..|:  ..:|..||.:|..|||..:.::||||.::.:.:
Mouse   523 TSNLATEE------IERDLRRSLPEHPAFQ--SDTGISALRRVLTAYAYRNPKIGYCQAMNILTS 579

  Fly   744 SLLLHMPEEDAFCVLVA----LMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACG 804
            .|||:..||:||.:|||    ::.||..|.:..|..:...     .|.||:|.||:|.:|.|
Mouse   580 VLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAV-----FEELIRDHLPQLTDHMT--- 636

  Fly   805 IETHMYAS---QWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGI 866
             :...::|   .|||||:.:..|:....:|:|.|..||:..:.|:.   |:|.:.:|.:|
Mouse   637 -DMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLG---LAILDYNLDKL----- 692

  Fly   867 LKYFRVTLPKKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEER 931
                     ..|:..::|...:.:..:..|.|              ...|....|...|...|:.
Mouse   693 ---------LTCKDDAEAVTALNRFFDNVINK--------------DSPLPSNVQQGSNISNEKS 734

  Fly   932 RKMQAEIDALNKQLTSAKERAVEKEKKHTGIIQEYKQIIQRQEQDMNTLSETLGK-VMHMVSNCQ 995
            ...:.:|..|.|: ::.|..::..|..|:...:....:||       ||.||..: |:.:||  |
Mouse   735 DHTKVDITDLIKE-SNEKYGSIRYEDIHSMRCRNRLYVIQ-------TLEETTKQNVLRVVS--Q 789

  Fly   996 DCQ---QQID 1002
            |.:   |::|
Mouse   790 DVKMSLQELD 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	69/225 (31%)
		Phage_Gp23	<914..991	CDD:287621	17/77 (22%)
Tbc1d8b	NP_001074968.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..420		5/25 (20%)
		TBC	485..693	CDD:214540	70/241 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	938..957
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1032..1061

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810