Protein Alignment GAPcenA and RABGAP1

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_036329.3
• Gene: RABGAP1 / 23637
• HGNCID: 17155
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 1191
• Identity: 429/1191 - (36%)
• Similarity: 618/1191 - (51%)
• Gaps: 213/1191 - (17%)

  Fly     1 MDDNLST---KSSESSITTSGEYEIVTDSNVASPMEQVKQVVNQEGTQPEVGGKPPTSLSALALS 62
            |||..|.   ..|..|::|....:.|              :|:::|.:     .|.|:
Human     1 MDDKASVGKISVSSDSVSTLNSEDFV--------------LVSRQGDE-----TPSTN------- 39

  Fly    63 SPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTG 127
              ....|....|.:..|.:...:|.|:.|.|.|..::   ...|||   .|....|      |.|
Human    40 --NGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMD---DQPGEK---ELVKRSQ------LDG 90

  Fly   128 SGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKPEKGDTT 192
            .|.|.:..::                .|||:           |:..|....:|.:...|.|....
Human    91 EGDGPLSNQL----------------SASST-----------INPVPLVGLQKPEMSLPVKPGQG 128

  Fly   193 DEEVSE-----IDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCS 252
            |.|.|.     .|:...:||.:||||.|::|||:||.|..|:|..|.|..: :.|.:|:|:||.|
Human   129 DSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQCQ-ISLDVTLSVPNVS 192

  Fly   253 EGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDA-LFQCHVFRCHIPEAVN 316
            ||:|.|.|.::||.||.|.|..|:...||...|.|:.|||||..|.:| ||:.|||||.|.|||:
Human   193 EGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCEIQEAVS 257

  Fly   317 QVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAKNSYAAV 381
            ::...|..||:........|..:|   ..:..||:         :.|.|||||:|...|..::||
Human   258 RILYSFATAFRRSAKQTPLSATAA---PQTPDSDI---------FTFSVSLEIKEDDGKGYFSAV 310

  Fly   382 P--RDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHSMGY 444
            |  :||.|||||...||::.|.|:||.:   :.|.||||||:|::|||.|...||||:|:.|||
Human   311 PKDKDRQCFKLRQGIDKKIVIYVQQTTN---KELAIERCFGLLLSPGKDVRNSDMHLLDLESMG- 371

  Fly   445 IQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN---LTVAVDIVMRRIQE 506
                            :.|....|.|...|..:...|:.:|.|:.|..   :|.|||:|:..:||
Human   372 ----------------KSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEVQE 420

  Fly   507 PVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEIT--EQPGH 569
            ||||::||.|.:.|.:| |:...| |||..|..|:|.||:.::...| |:.|...|:.  |....
Human   421 PVRFLLETKVRVCSPNE-RLFWPF-SKRSTTENFFLKLKQIKQRERK-NNTDTLYEVVCLESESE 482

  Fly   570 QQSSSLLKMGMNNLSRIVRSSSIASIEDDCP-SDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPI 633
            ::..   |...:...|:.:|.|.:|:....| .|...|.|||||||:|:|||:|::..|:.|..:
Human   483 RERR---KTTASPSVRLPQSGSQSSVIPSPPEDDEEEDNDEPLLSGSGDVSKECAEKILETWGEL 544

  Fly   634 LREW--DSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKETKCETVIQRD 696
            |.:|  :...|||.|:.|||.|||||||.::||.||.......:.:||:||||||:..::.|.||
Human   545 LSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKESPQDSAITRD 609

  Fly   697 IHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVAL 761
            |:||||||..||:.||.|||:|:|:.|||:|:|.|:|||||.||:||.||||||||.||.|||.:
Human   610 INRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKI 674

  Fly   762 MYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLC 826
            |:|||||:|:|..||.|:.:.||||||:::.:|.|:.||....:|.|||||||||||:||:|||.
Human   675 MFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLY 739

  Fly   827 FVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQA 891
            .|||::|:.|.:|:.|:|.||:.||...:.||...||||.||:|||.|||:.||...|:|:|:.|
Human   740 MVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELA 804

  Fly   892 CERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYE--NRFGEERRKMQ----------------- 935
            |..||  ||||:||:|:     |..| |::||..:  .||..|.|::|
Human   805 CNMKISQKKLKKYEKEY-----HTMR-EQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHEL 863

  Fly   936 ---------------AEIDALNKQLTSAKERAVEKE----------------------------K 957
                           .:.|||||:|...|::.::.|                            |
Human   864 VTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIK 928

  Fly   958 KHTGIIQEYKQII----QRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDAGNDNAKSDDGKNRGQ 1018
            |::.||.:||||.    :|.|:........:.|:...|.:|:.|::..        :.:|:.:|.
Human   929 KNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCERCREFF--------NKEGRVKGI 985

  Fly  1019 TDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSNTLSELQTNRN 1083
            :......:|......:.|   ..::||:||||||.||..||||||.|||.|.|...|:|:|..:.
Human   986 SSTKEVLDEDTDEEKETL---KNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQAAKK 1047

  Fly  1084 SWQPWLSKTFNSLQEKVTTRG 1104
            :   |.::|.:|::.....:|
Human  1048 T---WFNRTLSSIKTATGVQG 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	60/128 (47%)
		DUF3694	377..523	CDD:463599	59/150 (39%)
		TBC	650..858	CDD:214540	118/207 (57%)
		SMC_prok_B	<876..>1087	CDD:274008	77/278 (28%)
		TPH	<883..>977	CDD:464007	42/161 (26%)
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79		20/108 (19%)
		PTB_Rab6GAP	145..273	CDD:269922	60/128 (47%)
		DUF3694	307..437	CDD:463599	59/149 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..527		15/47 (32%)
		TBC	563..772	CDD:214540	119/208 (57%)
		SMC_prok_B	<825..>1032	CDD:274008	53/218 (24%)