Protein Alignment GAPcenA and Tbc1d17

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001036120.1
• Gene: Tbc1d17 / 233204
• MGIID: 2449973
• Length: 645
• Species: Mus musculus
• Alignment Length: 579
• Identity: 120/579 - (20%)
• Similarity: 203/579 - (35%)
• Gaps: 179/579 - (30%)

  Fly   443 GYIQPGGTGVAT--------ESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDI 499
            || :|....::|        |....|:.|||     |:.|.......|..::..||..|:.|..:
Mouse    83 GY-EPDWAVISTVRPQPHLAEPRKGAEPSSS-----RSSWAFSVSLGELKSIRRSKPGLSWAYLV 141

  Fly   500 VMRRIQEPVRFVIETPVTIQSAS-------------EMRIMDHF--MSKRPMTLRFYLHLKRTEE 549
            :               ||....|             .:|::..:  ::..|...|.||
Mouse   142 L---------------VTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYL------- 184

  Fly   550 SNWKVNSIDPSEEITEQPGH-----QQSSSLLKMGM--------NNLSRIVR------------- 588
                |...||| .:::...|     |.||:::...:        ::.||:..
Mouse   185 ----VFPQDPS-ALSDSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPHPEGA 244

  Fly   589 -SSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDC----SQDTLDEWDPIL-REWD----SEKRP 643
             |.::..:.||.|        ||   |...:|  |    .:.|::...|:. .||:    .|.|.
Mouse   245 SSPNLPPLPDDEP--------EP---GFEVIS--CVELGQRPTVERAPPVTEEEWNRYVGPEGRL 296

  Fly   644 KNLAPLVRL----GVPEALREKIWQKLANVEGRMEMNDKYKILITKETK---------------- 688
            :|:..|...    |:...||.:.|:.|..........:::|..:.|:|.
Mouse   297 QNVPELKNRIFSGGLSPGLRREAWKFLLGYLSWESSAEEHKAHVRKKTDEYFRMKLQWKSVSAEQ 361

  Fly   689 ---------CETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAAS 744
                     ..::|:||:.||...:|.::.....|...|..:...|.::..::||.||:|.:.:.
Mouse   362 ERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLSLLHDILLTYCMYHFDLGYVQGMSDLLSP 426

  Fly   745 LLLHMPEE-DAF-CVLVALMYDYGLRDLYKAGFE-----------VLYLRLYQLERLIKDQLPKL 796
            :|..:..| ||| |..       |..:|....||           .|.|.|..|::.:.|.|..
Mouse   427 ILFVVQNEVDAFWCFC-------GFMELVHGNFEESQETMKRQLGQLLLLLRVLDQPLCDFLDS- 483

  Fly   797 HEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLP---VLFQVAVTLLSICESDL 858
            .:..:.|      :..:|.|..:...||...|..:.:| |..|||   :...||..:|.: |.|.
Mouse   484 QDSGSLC------FCFRWLLIWFKREFPFPDVLRLWEV-LWTGLPGPNLHLLVACAILDM-ERDT 540

  Fly   859 RQLDFEG---ILKYFRVTLPKKCRSS--SQARKVMKQ--ACE------RKIKKLKQYEE 904
            ..|...|   |||:......|.....  ::|..:.:|  ||.      ::|..|.|.||
Mouse   541 LMLSGFGSNEILKHINELTMKLSVEDVLTRAEALYRQLTACPELPHNVQEILGLAQPEE 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256	19/100 (19%)
		TBC	650..858	CDD:214540	53/252 (21%)
		Phage_Gp23	<914..991	CDD:287621
Tbc1d17	NP_001036120.1	DUF3548	3..217	CDD:192931	32/166 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..85		2/2 (100%)
		Required for interaction with OPTN. /evidence=ECO:0000250	217..309		19/104 (18%)
		TBC	307..542	CDD:214540	54/250 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..645		3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900