DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and TBC1D12

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_056003.1	Gene:	TBC1D12 / 23232	HGNCID:	29082	Length:	775	Species:	Homo sapiens

Alignment Length:	977	Identity:	203/977 - (20%)
Similarity:	306/977 - (31%)	Gaps:	371/977 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EYEIVTDSNVASPMEQVKQVVNQEGTQPEVG-----------GKPPTSLSALALSSPEAGGDRSP 72
            |.|...:.....|.:.:::.:...|.|.|.|           |.||.|.:..:.:.....|.:..
Human    54 EEEEADEEEETPPRQLLQRYLAAAGEQLEPGLCYCPLPAGQAGAPPPSAAPRSDACLLGSGSKHR 118

  Fly    73 TLDMAHNRNLSDMQHE-MTDA---------LKDLELERGVA-ASGEKSAQRLPSHQQKSLTLPLT 126
            ..::|..|   ..:|| ||:.         .:|||..||:| |.|.:|.:|.|..:     |.|.
Human   119 GAEVADGR---APRHEGMTNGDSGFLPGRDCRDLEEARGLARAGGRESRRRRPYGR-----LRLE 175

  Fly   127 GSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCID-ASP------ACVEEKQDAM 184
            |.|                   :|..|.|.|.:           | |||      :|.....||.
Human   176 GPG-------------------DEDADGAGSPS-----------DWASPLEDPLRSCCLVAADAQ 210

  Fly   185 KPE-----KGDTTDEEVSEIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKI 244
            :||     .||:.....|..:.......|.   |.....||.:.:      .|..:|.....|
Human   211 EPEGAGSDSGDSPASSCSSSEDSEQRGVGA---GGPEEGAPPATS------AERTNGGAEPRL-- 264

  Fly   245 TVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDALFQCHVFRC 309
                     |...:|....|    |:::|      ||                       ...|.
Human   265 ---------GFSDIHFNSRN----TFQVS------RG-----------------------QSARD 287

  Fly   310 HIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGY-EFIVSLEIRERV 373
            |:|.|              .||       ..:..|....:..|.....:.|: :|..
Human   288 HLPPA--------------GPP-------VPLPAAEQGPAGASARARRSGGFADFFT-------- 323

  Fly   374 AKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPG-KLVVQKDMHLI 437
                       |..|..|....|.|                      |..||| ||
Human   324 -----------RNLFPKRTKELKSV----------------------VHSAPGWKL--------- 346

  Fly   438 DMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKA-------------QEKAFE------- 482
                .|.:.|         ..|.|::|.   .|:.|::|             :.|.||
Human   347 ----FGKVPP---------RENLQKTSK---IIQQEYEARTGRTCKPPPQSSRRKNFEFEPLSTT 395

  Fly   483 QLNLESSKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRT 547
            .|.||...:||..      :.::|.:|...|....:..|.:..|.:....||.|..||      .
Human   396 ALILEDRPSNLPA------KSVEEALRHRQEYDEMVAEAKKREIKEAHKRKRIMKERF------K 448

  Fly   548 EESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEPLL 612
            :|.|                                   :.|:.:..|.:
Human   449 QEEN-----------------------------------IASAMVIWINE--------------- 463

  Fly   613 SGTGEVSKDCSQDTLDEWDPILREWDSEKRPKNLAPLVRLGVPEALREKIWQ-KLANVEGRMEMN 676
                                ||..|:..:..:.:..|...|:|.::|.|:|. .:.|     |:|
Human   464 --------------------ILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGN-----ELN 503

  Fly   677 ---DKYKILITK---------ETKCET---------------VIQRDIHRTFPAHKCFKEIGGSG 714
               :.|:|.:::         ||..|.               :|:.||.||||:...|:: ||..
Human   504 ITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISRTFPSLYIFQK-GGPY 567

  Fly   715 QDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAF----------CVLVALMYDYGLRD 769
            .|.|..:..||..:..:|||.||:|||||.|:|::.|.|||          |.|.....|:.:..
Human   568 HDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMML 632

  Fly   770 LYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFHVLDV 834
            .|.|.|||.:          ::.|.||..||.:..:...:|...|..|||:...||.....|.||
Human   633 KYFATFEVFF----------EENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDV 687

  Fly   835 FLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERKIKKL 899
            |..||...||:..:.:|.:.|..|.|:||..|.: |...||:...|......:.....:...||.
Human   688 FCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQ-FLTKLPEDITSEKLFSCIAAIQMQNSTKKW 751

  Fly   900 KQ 901
            .|
Human   752 TQ 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	19/127 (15%)
		DUF3694	429..523	CDD:289256	20/113 (18%)
		TBC	650..858	CDD:214540	73/245 (30%)
		Phage_Gp23	<914..991	CDD:287621
TBC1D12	NP_056003.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..312		64/329 (19%)
		TBC	481..712	CDD:214540	73/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810