DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAPcenA and Rabgap1

DIOPT Version :9

Sequence 1:NP_001097549.1 Gene:GAPcenA / 38945 FlyBaseID:FBgn0035879 Length:1194 Species:Drosophila melanogaster
Sequence 2:NP_001349885.1 Gene:Rabgap1 / 227800 MGIID:2385139 Length:1064 Species:Mus musculus


Alignment Length:1201 Identity:430/1201 - (35%)
Similarity:616/1201 - (51%) Gaps:238/1201 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDDNLST---KSSESSITTSGEYEIVTDSNVASPMEQVKQVVNQEGTQPEVGGKPPTSLSALALS 62
            |||..|.   ..|..|::|....:.|              :|:::|.:     .|.|:       
Mouse     1 MDDKASVGKISVSSDSVSTLNSEDFV--------------LVSRQGDE-----TPSTN------- 39

  Fly    63 SPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPSHQQKSLTLPLTG 127
              ....|....|.:..|.:...:|.|:.|.|.|..::   ...||:|              .|.|
Mouse    40 --NGSDDEKTGLKIVGNGSEQQLQKELADVLMDPPMD---DQPGERS--------------QLDG 85

  Fly   128 SGGGSVDPEMRFPCTL------FTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEKQDAMKP 186
            .|.|.:..::....|:      ..||.|.:|                              .:||
Mouse    86 EGDGPLSNQLSASSTINPVPLVGLPKPEMSL------------------------------PVKP 120

  Fly   187 EKGDTTDEEVSE-----IDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITV 246
            .:||:   |||.     .|:...:|:.:||||.|::|||:||.|..|:|..|.|..: :.|.:|:
Mouse   121 GQGDS---EVSSPFTPVADEDSVVFNKLTYLGCASVNAPRSEVEALRMMSILRSQCQ-ISLDVTL 181

  Fly   247 SIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDA-LFQCHVFRCH 310
            |:||.|||.|.|.|.::||.||.|.|..|:...||...|.|:.|||||..|.:| ||:.|||||.
Mouse   182 SVPNVSEGTVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHYNAELFRIHVFRCE 246

  Fly   311 IPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRERVAK 375
            |.|||:::...|..||:........|..:|   ..:..||:         :.|.|||||:|...|
Mouse   247 IQEAVSRILYSFATAFRRSAKQTPLSATAA---PQTPDSDI---------FTFSVSLEIKEDDGK 299

  Fly   376 NSYAAVP--RDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLID 438
            ..::|||  :||.|||||...||::.|.|:||.:   :.|.||||||:|::|||.|...||||:|
Mouse   300 GYFSAVPKDKDRQCFKLRQGIDKKIVICVQQTAN---KELAIERCFGLLLSPGKDVRNSDMHLLD 361

  Fly   439 MHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN---LTVAVDIV 500
            :.|||                 :.|....|.|...|..:...|:.:|.|:.|..   :|.|||:|
Mouse   362 LESMG-----------------KSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLV 409

  Fly   501 MRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITE 565
            :..:||||||::||.|.:.|.:| |:...| |||..|..|:|.||:.::.. |.|:.|...|:. 
Mouse   410 ITEVQEPVRFLLETKVRVCSPNE-RLFWPF-SKRSTTENFFLKLKQIKQKE-KKNNADTLYEVV- 470

  Fly   566 QPGHQQSSSLLKMGMNNLSRIVR-------SSSIASIEDDCPSDYSSDGDEPLLSGTGEVSKDCS 623
               ..:|.|..:......|..||       ||.|.|..:|   |...|.|||||||.|:|||:|:
Mouse   471 ---CLESESERERRKTTASPSVRLPQSGSQSSMIPSPPED---DEEEDNDEPLLSGFGDVSKECA 529

  Fly   624 QDTLDEWDPILREW--DSEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMNDKYKILITKE 686
            :..|:.|..:|.:|  :...|||.|:.|||.|||||||.::||.||.......:.:||:||||||
Mouse   530 EKILETWGELLSKWHLNLSVRPKQLSSLVRSGVPEALRGEVWQLLAGCHNNDHLVEKYRILITKE 594

  Fly   687 TKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPE 751
            :..::.|.|||:||||||..||:.||.|||:|:|:.|||:|:|.|:|||||.||:||.|||||||
Mouse   595 SPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPE 659

  Fly   752 EDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFL 816
            |.||.|||.:|:|||||:|:|..||.|:.:.||||||:::.:|.|:.||....:|.|||||||||
Mouse   660 EQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 724

  Fly   817 TLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSS 881
            ||:||:|||..|||::|:.|.:|:.|:|.||:.||...:.||...||||.||:|||.|||:.||.
Mouse   725 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSE 789

  Fly   882 SQARKVMKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYE--NRFGEERRKMQ------- 935
            ..|:::|:.||..||  ||||::|:|:     |..| |::||..:  .||..|.|::|       
Mouse   790 ENAKRLMELACNTKISQKKLKKFEKEY-----HTMR-EQQAQQEDPIERFERENRRLQEANMRLE 848

  Fly   936 -------------------------AEIDALNKQLTSAKERAVEKE------------------- 956
                                     .:.|||||:|...|::.::.|                   
Mouse   849 QENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKRRLEEESAQLKEMCRR 913

  Fly   957 ---------KKHTGIIQEYKQII----QRQEQDMNTLSETLGKVMHMVSNCQDCQQQIDAGNDNA 1008
                     ||::.||.:||||.    :|.|:........:.|:...|.:|..|:...       
Mouse   914 ELDKAESEIKKNSSIIGDYKQICSQLSERLEKQQTANKVEIEKIRQKVDDCDRCRDFF------- 971

  Fly  1009 KSDDGKNRGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSN 1073
             :.:|:.:|.:.|...::|......:.|   ..::||:||||||.||..||||||.|||.|.|..
Mouse   972 -NKEGRVKGISSAKGVSDEDTDEEKETL---KNQLREMELELAQTKLQLVEAECKIQDLEHHLGL 1032

  Fly  1074 TLSELQTNRNSWQPWLSKTFNSLQEKVTTRG 1104
            .|||:|..:.:   |.::|.:|::.....:|
Mouse  1033 ALSEVQAAKKT---WFNRTLSSIKTATGVQG 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAPcenANP_001097549.1 PTB_Rab6GAP 204..332 CDD:269922 59/128 (46%)
DUF3694 429..523 CDD:289256 32/96 (33%)
TBC 650..858 CDD:214540 118/207 (57%)
Phage_Gp23 <914..991 CDD:287621 28/142 (20%)
Rabgap1NP_001349885.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..101 27/144 (19%)
PTB_Rab6GAP 140..268 CDD:269922 59/128 (46%)
DUF3694 302..432 CDD:315198 59/149 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..520 15/44 (34%)
TBC 558..767 CDD:214540 119/208 (57%)
ERM 789..1013 CDD:330563 57/240 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 260 1.000 Domainoid score I1960
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H49301
Inparanoid 1 1.050 621 1.000 Inparanoid score I876
Isobase 1 0.950 - 0 Normalized mean entropy S2807
OMA 1 1.010 - - QHG49205
OrthoDB 1 1.010 - - D191811at2759
OrthoFinder 1 1.000 - - FOG0000497
OrthoInspector 1 1.000 - - otm43139
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22957
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3994
SonicParanoid 1 1.000 - - X1488
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.920

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