Protein Alignment GAPcenA and tbc-11

DIOPT Version :9

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_508178.2
• Gene: tbc-11 / 180444
• WormBaseID: WBGene00018075
• Length: 934
• Species: Caenorhabditis elegans
• Alignment Length: 1014
• Identity: 329/1014 - (32%)
• Similarity: 525/1014 - (51%)
• Gaps: 177/1014 - (17%)

  Fly   194 EEVSEIDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVGLKITVSIPNCSEGLVVL 258
            ::.:|:.|    |:.|.|||.:.:....::.|:..:|..|:....:..:.:|:.:|:...|.|.|
 Worm     5 KDFTEVTQ----FTNVQYLGCSQLVNNDNDNEMKALMKVLDEQKGAQTINVTLVVPHNISGTVKL 65

  Fly   259 HDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLH---------GDALFQCHVFRCHIPEA 314
            .||:.. :::::.:.:|....||...|.:|.||..::.|         .|.|.||||||....|.
 Worm    66 IDAQGK-VLSSFSLVNIRFCIRGESSTSQNNCFGISFTHKISVGEHNSSDILHQCHVFRTSKAET 129

  Fly   315 VNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEFIVSLEIRER---VAKN 376
            ..:....|..||..                .:|:|:     .|...::|...||::|.   |.|.
 Worm   130 AAKALYSFSYAFSN----------------KNVSSE-----SNRLEFQFESILEVKENDGTVEKP 173

  Fly   377 SYAAVPRDRGCFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLVVQKDMHLIDMHS 441
            |:...|:..|.||:|.:.:|::.:.::|....:   |:|::|||:|:|.|:.:...|:.|::|
 Worm   174 SWKLCPQHNGVFKVRRDREKKIVVQLRQIDGFL---LNIKKCFGMLLAAGRNLRHSDLQLLEM-- 233

  Fly   442 MGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLES---SKTNLTVAVDIVMRR 503
                           |.||..:.|..:.|.|.|..:...||.||.|:   ::..:|||:|:::..
 Worm   234 ---------------DRNATGTDSAVFVIEANWDPRVHMFEVLNTETPRDTRVFMTVAIDVIVSE 283

  Fly   504 IQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTL---RFYLHLKRTEESNWKVNSIDPSEE--- 562
            |.||:||.:|....:....|.      ..|.|.|:   .|.|.|:::.:.:      ||::.
 Worm   284 ISEPIRFSMEAMSRVFHEHER------FYKTPQTVVSEEFTLVLEKSCDQS------DPNDRKLT 336

  Fly   563 -ITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPS-DYSSDGDEPLLSGTGEVSKDCSQD 625
             |:     .:|.|..|....||.   :|.|....:...|: |..||.|||||||:|:||::|.::
 Worm   337 FIS-----LESDSDRKRSKQNLG---KSPSRMPTQLLHPTGDDESDCDEPLLSGSGKVSQECKEE 393

  Fly   626 TLDEWDPILREWDSEK-RPKNLAPLVRLGVPEALREKIWQKLANVE----GRMEMNDKYKILITK 685
            .|:.||.::..||.:. ||:.::.||..|:|:.||.::||.|:||.    .:.::.:||.|.:::
 Worm   394 HLEMWDQLIENWDQQSDRPQKISELVLDGIPDKLRGRVWQLLSNVRILAIDQPDLVEKYHIFLSQ 458

  Fly   686 ETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMP 750
            ....|.||.||||||||||..|||..|.||.:|:|:||.|:::|.||.|||||||:|||||||||
 Worm   459 PCPSEQVIMRDIHRTFPAHDYFKESQGKGQQSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHMP 523

  Fly   751 EEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWF 815
            ||.|||.||.:|::||||||:|.||:.|:||.:||..|:||.:|.|..|....||||||||||||
 Worm   524 EEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDLSHHLEHIGIETHMYASQWF 588

  Fly   816 LTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRS 880
            |||:||:|||..||.:||:||..|:..:|.:::.||...::||.||||||.||||||:||:|.|:
 Worm   589 LTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQLDFEGTLKYFRVSLPRKYRT 653

  Fly   881 SSQARKVMKQACERKI--KKLKQYEEEFL----LKKQHKE---RLEKEAQIYE-NRFGEERR--- 932
            .:..:.::.:|.:.::  .||:.||.|:.    |::::::   |:|||...:: |....||.
 Worm   654 EASTKCLIHKAVKFRLNHSKLEVYENEYKRIKELERENEDPVLRMEKEIGRHQANTLRLERENDD 718

  Fly   933 ----------KMQAEIDALNKQL-TSAK--ERAVEKE----KKHTGIIQEYKQIIQRQEQDMNTL 980
                      :::.::|....|: |||.  ||...:.    :::..:::||:||.:...:|:..|
 Worm   719 LAHELVTSKIELRRKLDVAEDQIETSANAIERLTRQNMDILEENKNLMREYEQIKEMYRRDVLRL 783

  Fly   981 SETLGK--------------------------------VMHMVSNCQDCQQQIDAGNDNAKSDDG 1013
            .|...:                                ::..:|:|..|..        |..:..
 Worm   784 EENGSRAEKLLAEYKKLFSERSKRAENEREHFEVQKKAIIARISDCDKCWP--------AVCEWE 840

  Fly  1014 KNRGQTDAMRNANEHPLGP--LDPLNAASQRIRELELELAQAKLAQVEAECKNQDLNHQLSNTLS 1076
            |||...    ::...|.||  |..|......|:.||::|||.||:.|||||:||||.|||
 Worm   841 KNRSPV----HSASTPTGPDLLTKLEEREDHIKNLEIDLAQTKLSLVEAECRNQDLTHQL----- 896

  Fly  1077 ELQTNRNSWQPWLSKTFNSLQEKVTTRGGH-RDNGSGGP 1114
             :..:.:..:.|..||...|:|..::...| |.|.|..|
 Worm   897 -MAQSESDGKKWFKKTITQLKEVGSSLKHHERSNSSVTP 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	35/136 (26%)
		DUF3694	429..523	CDD:289256	25/96 (26%)
		TBC	650..858	CDD:214540	114/211 (54%)
		Phage_Gp23	<914..991	CDD:287621	21/132 (16%)
tbc-11	NP_508178.2	PH-like	11..147	CDD:388408	36/156 (23%)
		DUF3694	183..293	CDD:372133	38/129 (29%)
		TBC	419..632	CDD:214540	115/212 (54%)
		Smc	<697..>901	CDD:224117	53/221 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164727
Domainoid	1	1.000	237	1.000	Domainoid score	I1300
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49301
Inparanoid	1	1.050	473	1.000	Inparanoid score	I831
Isobase	1	0.950	-	0	Normalized mean entropy	S2807
OMA	1	1.010	-	-		QHG49205
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		oto19195
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3994
SonicParanoid	1	1.000	-	-		X1488
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.990