DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and tbc-17

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001022434.2	Gene:	tbc-17 / 174900	WormBaseID:	WBGene00012894	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1315	Identity:	250/1315 - (19%)
Similarity:	414/1315 - (31%)	Gaps:	463/1315 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NLST--KSSE---SSITTSGEYEIVTDSNVASPMEQVKQVVNQEGTQPEVGGKPPTSLSALALSS 63
            |..|  |||:   :::::.|:|:   |.|        |..:.:.....|.||            .
Worm    28 NFGTPPKSSDHQKNNMSSGGDYK---DYN--------KMGIRKASGSSERGG------------I 69

  Fly    64 PEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLELERGVAASGEKSAQRLPS------HQQKSLT 122
            ...||...||.|:.:.|..::.:|....: ...:..|  ..|.::.:|..|:      ||...:.
Worm    70 TGGGGGGGPTDDILYERVHTERRHHHQTS-SPSQYPR--PPSRDRESQPPPTQPRHHHHQPTVIH 131

  Fly   123 LPLTGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFY-----DCIDASPAC------ 176
            .|:..:|.         |..:..|.|      .|....:|.|..:     |.:..||..
Worm   132 HPIRSTGS---------PPVMMAPMS------TSYDYSIGSSAGFRKQELDELHKSPGSRWAARG 181

  Fly   177 VEEKQDAMKPEKGDTTDEEVSEIDQGCTIFSGVTYLGAANIN---APKSETEVYRIMGELNSGSK 238
            .:::|:..:|                     |.....||||:   |||             |||:
Worm   182 AQQQQEDFRP---------------------GPRASSAANIDALFAPK-------------SGSR 212

  Fly   239 SVGLKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFTWLHGDALFQ 303
            :                   ..|.|::               ||...:..|
Worm   213 T-------------------QSASSSS---------------GPSSRMAGG-------------- 229

  Fly   304 CHVFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSVTSDVSGNPLNTAGYEF-IVSL 367
                                     |.||      ...:|||.|.|..|..|...:..:| :|..
Worm   230 -------------------------YEPS------GGENMANVVFSRKSAAPRGASDKDFGVVGA 263

  Fly   368 EIRERVAK---------------NSYAAVP---RDRGCFKLRANTDKEVCITVKQ---------- 404
            ...||.|:               ||..|.|   :....::|    |..:.:|..|
Worm   264 YSSERRAEQQAGGAGGGYGRRGGNSSGAKPQVCQHSNDYEL----DPRLNVTYPQFYVDDWKDRH 324

  Fly   405 TPSNVLQPLH---------------------IER-----CFGVLVAP-----GKLVVQKDMHLID 438
            :|.:...|.|                     :.|     .....|.|     |:.....|.|
Worm   325 SPHHSHHPQHHQVVGNMTPTASSSGGYPRVPVPRHSPSFTSSATVYPLPGTGGRPRFGSDAH--- 386

  Fly   439 MHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTNLTVAVDIVMRR 503
            .|....:..||.|..:.::...:.....||                  .|:.||:
Worm   387 RHLYEEVPMGGGGGPSVTNGGYRSPGGPPY------------------GSASTNM---------- 423

  Fly   504 IQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPG 568
                              .|..|:|.:.:.....|...:|.|.|.:.:.|    :..|....|||
Worm   424 ------------------RETAILDDYDNVPSEFLAENVHRKHTTKDDVK----EDGESGIYQPG 466

  Fly   569 HQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDEP----------------------- 610
            ..|.|                      ||   :|.|||.|:|
Worm   467 RYQPS----------------------ED---ADSSSDEDDPEYLELMERDSIINRYEKGPDAAD 506

  Fly   611 -------------LLSGTGEVSKDCSQDTLDE------------------WDPILREWDSEKRPK 644
                         .|...|.|.|...:.|.||                  |..::..|.|....|
Worm   507 VDAWENPNFELYTNLDRFGFVHKKGEKATADERTDLQKRRIIKELSREKKWLKMIEVWKSGGPSK 571

  Fly   645 NLAPLVRLGVPEALREKIWQKLANVEG-RMEMNDKY------KILITKETKCETVIQRDIHRTFP 702
            .:...:..|:||.||..||.:|...|. :.|..|.|      ..|::|:.|   .|..||:||:.
Worm   572 KMEDRIWKGIPEKLRIVIWPRLLGAERLKHERRDVYAELLLRARLVSKDIK---QIDLDINRTYR 633

  Fly   703 AHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALMYD--Y 765
            .|..|::.....|.:|..|..||::.::|||||||:|.|||..|:::.|||||..|..||..  :
Worm   634 DHLAFRKRYDVKQKSLLNVLAAYSMFNTEVGYCQGMSQIAALFLMYLDEEDAFWSLHQLMVSPKH 698

  Fly   766 GLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCFVFH 830
            .:...:..||..|.......:|::|...|::::|.....| .::|.::|:...:..|.|......
Worm   699 TMHGFFVPGFPKLQRYEEHFKRVLKKYKPRVYKHLEKQDI-PYIYLTKWWFGCFLDRVPFSLALR 762

  Fly   831 VLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQACERK 895
            :.||||::|..:|..:|..::.:.|.::|:.:.|..:::.:..:......|..  :|| .:....
Worm   763 LWDVFLVEGDCILIAMAYNIMKMHEKNVRKHNMESFMEFIQNDIAIDFGYSDD--EVM-HSLRET 824

  Fly   896 IKKLKQYEEEFLLKKQH---KERLEKEAQIYENRFGEERRKMQAEIDALNKQLTSAKERAVEKEK 957
            :.|||.       .:||   ..|.|..:::.....|...:|..|.|.....::.|.:.||
Worm   825 LSKLKS-------DRQHVPPPPRPEDLSEVPTKALGPILQKPMASIRDEIHEIQSRRSRA----- 877

  Fly   958 KHTGIIQEYKQIIQRQEQDMNTLSETLG--KVMHMVSNCQDCQQQIDAGNDNAKSDDGKN----- 1015
            ..||     :....::::.........|  .|.|..:.  :..|....||.......|:.
Worm   878 NSTG-----RSPYPKRKESARGAGAPKGPPPVQHKWNG--NASQDSILGNGGGGGAGGREVPFEI 935

  Fly  1016 ------------RGQTDAMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEAECKNQDLN 1068
                        ...|||..|:....|.|    :.:|:|      :..|:..........:....
Worm   936 PTRRAPNGSPAAAAPTDAYNNSKNGALPP----SGSSKR------DFVQSSNTPTTTTHSSSSHR 990

  Fly  1069 HQLSNT-------LSELQTNRNSWQPWLSKTFNSLQEKVTTRGGHRD---NGSGGPMPSFQSYMG 1123
            :|.||:       ...|:..|:.....||:..:|..:..:.....||   |||...:
Worm   991 YQHSNSSRGGTPLAQRLRDERSGQVVLLSRASDSEPDVGSPMTNTRDSDWNGSAAHI-------- 1047

  Fly  1124 QAPTTLSEASSPSGN 1138
               :|.:...:.|||
Worm  1048 ---STATSRITHSGN 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	17/130 (13%)
		DUF3694	429..523	CDD:289256	11/93 (12%)
		TBC	650..858	CDD:214540	67/216 (31%)
		Phage_Gp23	<914..991	CDD:287621	14/78 (18%)
tbc-17	NP_001022434.2	TBC	577..788	CDD:214540	66/214 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910